DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir40a and Gria2

DIOPT Version :9

Sequence 1:	NP_610140.4	Gene:	Ir40a / 35449	FlyBaseID:	FBgn0259683	Length:	732	Species:	Drosophila melanogaster
Sequence 2:	NP_001344853.2	Gene:	Gria2 / 14800	MGIID:	95809	Length:	901	Species:	Mus musculus

Alignment Length:	782	Identity:	154/782 - (19%)
Similarity:	279/782 - (35%)	Gaps:	211/782 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 IGNDESDTAIALTQIVRGLQQSSLAILALPSLALSDGVCQKERNVYLD-------DFLQRL---- 78
            |.||:.|      :..|.|.|              |...:|||.|.||       |.:.::
Mouse   183 INNDKKD------ETYRSLFQ--------------DLELKKERRVILDCERDKVNDIVDQVITIG 227

  Fly    79 -HRSNYKSVV----FSQTELFFQHIEENLQGANECISLILDEPNQLLNSLHDRHLGHRLSLFIFY 138
             |...|..::    |:..:|    ::....|||.....|:|..:.|            :|.||..
Mouse   228 KHVKGYHYIIANLGFTDGDL----LKIQFGGANVSGFQIVDYDDSL------------VSKFIER 276

  Fly   139 WGA----RWPPS-SRVIRFREPL---RVVVVTRPRKKAFRIYYNQ--------------ARPCSD 181
            |..    .:|.: :..|::...|   .|.|:|    :|||....|              |.|.
Mouse   277 WSTLEEKEYPGAHTATIKYTSALTYDAVQVMT----EAFRNLRKQRIEISRRGNAGDCLANPA-- 335

  Fly   182 SQLQLVNWYDGDNL--GLQRIPL--LPTALSVYANFKGRTFRVPVF----HSPP----WFWVTYC 234
                 |.|..|..:  .|:::.:  |...:....|.|...:.:.:.    :.|.    |..|...
Mouse   336 -----VPWGQGVEIERALKQVQVEGLSGNIKFDQNGKRINYTINIMELKTNGPRKIGYWSEVDKM 395

  Fly   235 NNSFEEDEEFNSLDSIEKRKVRVTG---------GRDHRLL--------------MLLSKHMNFR 276
            ..:..|....|....:|.:.|.||.         .::|.:|              ..::||..|:
Mouse   396 VVTLTELPSGNDTSGLENKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFK 460

  Fly   277 FKYIEAPGRTQGSMRSEDGKDSNDSFTGGIGLLQSGQADFFLGDVGLSWERRKAIEFS--FFTLA 339
            :| :...|..:...|..|.|..|    |.:|.|..|:||..:..:.::..|.:.|:||  |.:|.
Mouse   461 YK-LTIVGDGKYGARDADTKIWN----GMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLG 520

  Fly   340 DSGAFATHAPRRLNEAL-AIMRPFKQDIWPHLILTIIFSGPIFYGIIALPYIWRR----RWANSD 399
            .|  .....|::....: :.:.|...:||    :.|:|:   :.|:..:.::..|    .|...:
Mouse   521 IS--IMIKKPQKSKPGVFSFLDPLAYEIW----MCIVFA---YIGVSVVLFLVSRFSPYEWHTEE 576

  Fly   400 VEHLGELYIHMTYLKEITPRLLKLKPRTVLSAHQMPHQLFQKCIWFTLRLFLKQSCNELHNGYRA 464
            .|...|     |...|.|...                .:|.. :||:|..|::|.|:........
Mouse   577 FEDGRE-----TQSSESTNEF----------------GIFNS-LWFSLGAFMQQGCDISPRSLSG 619

  Fly   465 KFLTIVYWIAATYVLADVYSAQLTSQFARPAREPPINTLQRLQAAMIHDGYRLYVEKESSSLEML 529
            :.:..|:|. .|.::...|:|.|.:.........||.:.:.|.            ::...:...|
Mouse   620 RIVGGVWWF-FTLIIISSYTANLAAFLTVERMVSPIESAEDLS------------KQTEIAYGTL 671

  Fly   530 ENGT--ELFR--------QLYALMRQQVINDPQGFFIDSVEAGIKLIAEGGEDKAVLGGRETLFF 584
            ::|:  |.||        :::..||..   :|..|...:.|...::....|:...:|......:.
Mouse   672 DSGSTKEFFRRSKIAVFDKMWTYMRSA---EPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYI 733

  Fly   585 NVQQYGSNNFQLSQKLYTRYSAVAVQIGCPFLGSLNNVLMQLFESGILDKMTAAEYAKQYQEVEA 649
            . |:...:..::...|.::...:|...|......:|..:::|.|.|:|||:.    .|.:.:
Mouse   734 E-QRKPCDTMKVGGNLDSKGYGIATPKGSSLRTPVNLAVLKLSEQGVLDKLK----NKWWYD--- 790

  Fly   650 TRIYKGSVQAKNSEAYSRTESYDSTVISPLNLRMLQGAFIALGVGSLA-AGVILLLEIVFIKLDQ 713
                ||...||:|.:..:|        |.|:|..:.|.|..| ||.|. |.::.|:|..:....:
Mouse   791 ----KGECGAKDSGSKEKT--------SALSLSNVAGVFYIL-VGGLGLAMLVALIEFCYKSRAE 842

  Fly   714 AR 715
            |:
Mouse   843 AK 844

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir40a	NP_610140.4	PBP2_LTTR_substrate	216..338	CDD:330233	31/154 (20%)
		Periplasmic_Binding_Protein_Type_2	297..>391	CDD:328725	21/96 (22%)
		Periplasmic_Binding_Protein_Type_2	<496..637	CDD:328725	26/150 (17%)
Gria2	NP_001344853.2	PBP1_iGluR_AMPA_GluR2	28..398	CDD:380612	51/261 (20%)
Gria2	NP_001344853.2	PBP2_iGluR_AMPA	413..794	CDD:270433	83/444 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846586
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840