Protein Alignment Ir40a and GRIN3A

DIOPT Version :9

• Sequence 1: NP_610140.4
• Gene: Ir40a / 35449
• FlyBaseID: FBgn0259683
• Length: 732
• Species: Drosophila melanogaster
• Sequence 2: NP_597702.2
• Gene: GRIN3A / 116443
• HGNCID: 16767
• Length: 1115
• Species: Homo sapiens
• Alignment Length: 511
• Identity: 96/511 - (18%)
• Similarity: 173/511 - (33%)
• Gaps: 169/511 - (33%)

  Fly   235 NNSFEEDEEFNSL----DSIEKRKVRVTGGRDHRLLMLLSKHMNFRFK-YIEAPGRTQGSMRSED 294
            |:|...|..|:||    |::..:..:...|....||..:::.|||.|. ||...|:.
Human   549 NDSSTLDSLFSSLHSSNDTVPIKFKKCCYGYCIDLLEKIAEDMNFDFDLYIVGDGKY-------- 605

  Fly   295 GKDSNDSFTGGIGLLQSGQADFFLGDVGLSWERRKAIEFS--FF------------TLADSGAFA 345
            |...|..:||.:|.|..|.|...:....::..|.:.|:|:  ||            |.|..|||
Human   606 GAWKNGHWTGLVGDLLRGTAHMAVTSFSINTARSQVIDFTSPFFSTSLGILVRTRDTAAPIGAF- 669

  Fly   346 THAPRRLNEALAIMRPFKQDIWPHLILTIIFSGPIFYGIIALPYIWRRRWA-------NSDVEHL 403
                         |.|....:|..:.:.:..:. :|..:    |.|:..:.       .|.|...
Human   670 -------------MWPLHWTMWLGIFVALHITA-VFLTL----YEWKSPFGLTPKGRNRSKVFSF 716

  Fly   404 GELYIHMTYLKEITPRLLKLKPRTVLSAHQMPHQLFQKCIWFTLRLFLKQSCNELHNGYRAKFLT 468
            ... :::.|.. :..|.:.:||              .||                   :..:||.
Human   717 SSA-LNICYAL-LFGRTVAIKP--------------PKC-------------------WTGRFLM 746

  Fly   469 IVYWIAATYVLADVYSAQLTSQFARPAREPPINTLQRLQAAMIH---DGYRLYVEKESSSLEMLE 530
            .::.|...:.|: .|:|.|.   |....|.....|..:....:|   .|:|....:|||:.:.:.
Human   747 NLWAIFCMFCLS-TYTANLA---AVMVGEKIYEELSGIHDPKLHHPSQGFRFGTVRESSAEDYVR 807

  Fly   531 NGTELFRQLYALMRQQVI-----------NDPQ---GFFID--------SVEAGIKLIAEGGEDK 573
               :.|.:::..||:..:           |||:   .|.:|        |::|..||:..|..
Human   808 ---QSFPEMHEYMRRYNVPATPDGVEYLKNDPEKLDAFIMDKALLDYEVSIDADCKLLTVGKP-- 867

  Fly   574 AVLGGRETLFFNVQQYGSNNFQLSQKLYTRYSAVAVQIGCPFLGSLNNVLMQLFESGILDKMTAA 638
                      |.::.||                :.:....|...:::.::.|....|.:|.:
Human   868 ----------FAIEGYG----------------IGLPPNSPLTANISELISQYKSHGFMDML--- 903

  Fly   639 EYAKQYQEVEATRIYKGSVQAKNSEAYSRTESYDSTVISPLNLRMLQGAFIALGVG 694
             :.|.|:.|..         .|.|.|.:.|        ..:.::...|.|:.|.:|
Human   904 -HDKWYRVVPC---------GKRSFAVTET--------LQMGIKHFSGLFVLLCIG 941

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir40a	NP_610140.4	PBP2_LTTR_substrate	216..338	CDD:330233	30/121 (25%)
		Periplasmic_Binding_Protein_Type_2	297..>391	CDD:328725	22/107 (21%)
		Periplasmic_Binding_Protein_Type_2	<496..637	CDD:328725	28/165 (17%)
GRIN3A	NP_597702.2	PBP1_iGluR_NMDA_NR3	30..497	CDD:107372
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	59..118
		ANF_receptor	127..469	CDD:279440
		PBP2_iGluR_NMDA_Nr3	512..908	CDD:270438	86/459 (19%)
		Lig_chan	676..942	CDD:278489	59/362 (16%)
		PPP2CB binding site. /evidence=ECO:0000250	951..987
		GIT1-binding. /evidence=ECO:0000250|UniProtKB:Q9R1M7	1062..1095

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156087
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840