DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ir40a and GRIN3A

DIOPT Version :10

Sequence 1:NP_610140.4 Gene:Ir40a / 35449 FlyBaseID:FBgn0259683 Length:732 Species:Drosophila melanogaster
Sequence 2:NP_597702.2 Gene:GRIN3A / 116443 HGNCID:16767 Length:1115 Species:Homo sapiens


Alignment Length:511 Identity:96/511 - (18%)
Similarity:173/511 - (33%) Gaps:169/511 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   235 NNSFEEDEEFNSL----DSIEKRKVRVTGGRDHRLLMLLSKHMNFRFK-YIEAPGRTQGSMRSED 294
            |:|...|..|:||    |::..:..:...|....||..:::.|||.|. ||...|:.        
Human   549 NDSSTLDSLFSSLHSSNDTVPIKFKKCCYGYCIDLLEKIAEDMNFDFDLYIVGDGKY-------- 605

  Fly   295 GKDSNDSFTGGIGLLQSGQADFFLGDVGLSWERRKAIEFS--FF------------TLADSGAFA 345
            |...|..:||.:|.|..|.|...:....::..|.:.|:|:  ||            |.|..||| 
Human   606 GAWKNGHWTGLVGDLLRGTAHMAVTSFSINTARSQVIDFTSPFFSTSLGILVRTRDTAAPIGAF- 669

  Fly   346 THAPRRLNEALAIMRPFKQDIWPHLILTIIFSGPIFYGIIALPYIWRRRWA-------NSDVEHL 403
                         |.|....:|..:.:.:..:. :|..:    |.|:..:.       .|.|...
Human   670 -------------MWPLHWTMWLGIFVALHITA-VFLTL----YEWKSPFGLTPKGRNRSKVFSF 716

  Fly   404 GELYIHMTYLKEITPRLLKLKPRTVLSAHQMPHQLFQKCIWFTLRLFLKQSCNELHNGYRAKFLT 468
            ... :::.|.. :..|.:.:||              .||                   :..:||.
Human   717 SSA-LNICYAL-LFGRTVAIKP--------------PKC-------------------WTGRFLM 746

  Fly   469 IVYWIAATYVLADVYSAQLTSQFARPAREPPINTLQRLQAAMIH---DGYRLYVEKESSSLEMLE 530
            .::.|...:.|: .|:|.|.   |....|.....|..:....:|   .|:|....:|||:.:.:.
Human   747 NLWAIFCMFCLS-TYTANLA---AVMVGEKIYEELSGIHDPKLHHPSQGFRFGTVRESSAEDYVR 807

  Fly   531 NGTELFRQLYALMRQQVI-----------NDPQ---GFFID--------SVEAGIKLIAEGGEDK 573
               :.|.:::..||:..:           |||:   .|.:|        |::|..||:..|..  
Human   808 ---QSFPEMHEYMRRYNVPATPDGVEYLKNDPEKLDAFIMDKALLDYEVSIDADCKLLTVGKP-- 867

  Fly   574 AVLGGRETLFFNVQQYGSNNFQLSQKLYTRYSAVAVQIGCPFLGSLNNVLMQLFESGILDKMTAA 638
                      |.::.||                :.:....|...:::.::.|....|.:|.:   
Human   868 ----------FAIEGYG----------------IGLPPNSPLTANISELISQYKSHGFMDML--- 903

  Fly   639 EYAKQYQEVEATRIYKGSVQAKNSEAYSRTESYDSTVISPLNLRMLQGAFIALGVG 694
             :.|.|:.|..         .|.|.|.:.|        ..:.::...|.|:.|.:|
Human   904 -HDKWYRVVPC---------GKRSFAVTET--------LQMGIKHFSGLFVLLCIG 941

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ir40aNP_610140.4 Lig_chan-Glu_bd <265..336 CDD:463166 20/73 (27%)
Periplasmic_Binding_Protein_Type_2 297..>391 CDD:473866 22/107 (21%)
Periplasmic_Binding_Protein_Type_2 <496..637 CDD:473866 28/165 (17%)
GRIN3ANP_597702.2 PBP1_iGluR_NMDA_NR3 40..496 CDD:380600
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 59..118
PBP2_iGluR_NMDA_Nr3 512..908 CDD:270438 86/459 (19%)
Lig_chan 674..941 CDD:459656 58/362 (16%)
PPP2CB binding site. /evidence=ECO:0000250|UniProtKB:Q9R1M7 951..987
GIT1-binding. /evidence=ECO:0000250|UniProtKB:Q9R1M7 1062..1095
Blue background indicates that the domain is not in the aligned region.

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