DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir40a and Grik4

DIOPT Version :9

Sequence 1:	NP_610140.4	Gene:	Ir40a / 35449	FlyBaseID:	FBgn0259683	Length:	732	Species:	Drosophila melanogaster
Sequence 2:	NP_780690.2	Gene:	Grik4 / 110637	MGIID:	95817	Length:	956	Species:	Mus musculus

Alignment Length:	696	Identity:	135/696 - (19%)
Similarity:	237/696 - (34%)	Gaps:	197/696 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    87 VFSQTELFFQHIEENLQGANECISLILDEPNQLLNSLHDRHLGHRLSLFIFYWGARWPPSSRVIR 151
            :|:|:..|||                  |.:|.||.....:..|     :.:.|   |..|..:.
Mouse   270 IFNQSHAFFQ------------------EFSQSLNQSWQENCDH-----VPFTG---PALSSALL 308

  Fly   152 FREPLRVVVVTRPRKKAFRIYYNQARPCSDSQLQLVNWYDGDNL--GLQRIPLLPTALSVYANFK 214
            |.....||...:...::..|   ..:|.|....|:  |..|.:|  .|:.:.|......:..|.|
Mouse   309 FDAVYAVVTAVQELNRSQEI---GVKPLSCGSAQI--WQHGTSLMNYLRMVELEGLTGHIEFNSK 368

  Fly   215 GR--TFRVPVFHSPPWFWVTYCNNSFEEDEEF---------------NSLDSIEKRKVRVTGGRD 262
            |:  .:.:.:        :.:..|.|::..::               |..||:....:.||...:
Mouse   369 GQRSNYALKI--------LQFTRNGFQQIGQWHVAEGLSMDSRLYASNISDSLFNTTLVVTTILE 425

  Fly   263 HRLLMLLSKHMNFRFKYIEAPGRTQG---SMRSE---------------DG----KDSNDSFTGG 305
            :..|||...|..     :|...|.:|   .|..|               ||    .::|.::||.
Mouse   426 NPYLMLKGNHQE-----MEGNDRYEGFCVDMLKELAEILRFNYKIRLVGDGVYGVPEANGTWTGM 485

  Fly   306 IGLLQSGQADFFLGDVGLSWERRKAIEFS--FFTLADSGAFATHAPRRLNEALAIMRPFKQDIWP 368
            :|.|.:.:||..:..:.::.||.|.|:||  |.||..|..:..|..||.. ..:.:.||...:|.
Mouse   486 VGELIARKADLAVAGLTITAEREKVIDFSKPFMTLGISILYRVHMGRRPG-YFSFLDPFSPGVWL 549

  Fly   369 HLILTIIFSGPIFYGIIAL-PYIWRRRWANSDVEHLGELYIHMTYLKEITPRLLKLKPRTVLSAH 432
            .::|..:....:.:.:..| ||.|
Mouse   550 FMLLAYLAVSCVLFLVARLTPYEW----------------------------------------- 573

  Fly   433 QMPHQLFQ-KC------------IWFTLRLFLKQSCNELHNGYRAKFLTIVYWIAATYVLADVYS 484
            ..||...| :|            :||.:..|::|...........:.::.|:| |.|.::...|:
Mouse   574 YSPHPCAQGRCNLLVNQYSLGNSLWFPVGGFMQQGSTIAPRALSTRCVSGVWW-AFTLIIISSYT 637

  Fly   485 AQLTSQFARPAREPPINTLQRL--QAAM----IHDGYRLYVEKESSSLEMLENGTELFRQLYALM 543
            |.|.:.......|.||.::..|  |.|:    ||.|         ||:...:|..   .|.|..|
Mouse   638 ANLAAFLTVQRMEVPIESVDDLADQTAIEYGTIHGG---------SSMTFFQNSR---YQTYQRM 690

  Fly   544 RQQVINDPQGFFIDSVEAGIKLIAEGGEDKAVLGGRETLFFNVQQYGSNNFQLSQKLYTRYSAVA 608
            ...:.:.....|:.|.|.||..:........:   ..|:....:|...|..|:...|.|:...:.
Mouse   691 WNYMYSKQPSVFVKSTEEGIARVLNSNYAFLL---ESTMNEYYRQRNCNLTQIGGLLDTKGYGIG 752

  Fly   609 VQIGCPFLGSLNNVLMQLFESGILDKMTAAEYAKQYQEVEATRIYKGSVQAKNSEAYSRTESYDS 673
            :.:|..|....:..::||.|:..|             |:...:.::|....|..:..::
Mouse   753 MPVGSVFRDEFDLAILQLQENNRL-------------EILKRKWWEGGKCPKEEDHRAK------ 798

  Fly   674 TVISPLNLRMLQGAFIALGVGSLAAGVILLLEIVFIKLDQARLWML 719
                .|.:..:.|.|:.|..|.:.|..:.:||.         ||.|
Mouse   799 ----GLGMENIGGIFVVLICGLIVAIFMAMLEF---------LWTL 831

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir40a	NP_610140.4	PBP2_LTTR_substrate	216..338	CDD:330233	32/162 (20%)
		Periplasmic_Binding_Protein_Type_2	297..>391	CDD:328725	27/96 (28%)
		Periplasmic_Binding_Protein_Type_2	<496..637	CDD:328725	32/146 (22%)
Grik4	NP_780690.2	Periplasmic_Binding_Protein_type1	24..402	CDD:385651	30/170 (18%)
		PBP2_iGluR_kainate_KA1	415..785	CDD:270442	89/445 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	931..956
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846212
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840