DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir40a and LOC100149482

DIOPT Version :9

Sequence 1:	NP_610140.4	Gene:	Ir40a / 35449	FlyBaseID:	FBgn0259683	Length:	732	Species:	Drosophila melanogaster
Sequence 2:	XP_009290417.1	Gene:	LOC100149482 / 100149482	-ID:	-	Length:	1959	Species:	Danio rerio

Alignment Length:	463	Identity:	92/463 - (19%)
Similarity:	149/463 - (32%)	Gaps:	154/463 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   142 RWPPSSRVIRFREP------LRVVVVTRPRKKAFRIYYNQARPCSDSQLQLVNWYDG----DNLG 196
            |:|..||...|.:|      ||||.:   .::.|.|            ::|.:...|    |::.
Zfish   415 RYPAWSRYGPFLQPPDDAQHLRVVTL---EERPFVI------------VELADAASGTCIRDSVP 464

  Fly   197 LQRIPLLPTALSVYANFKGRTFRVPVFHSPPWFWVTYCNNSFEEDEEFNSLDSIEKRKVRVTGGR 261
            .:| ||..:||....             :|    |..|...|..|        |.||..|:.|..
Zfish   465 CRR-PLNASALQEGV-------------AP----VKQCCKGFCID--------ILKRLARIVGFT 503

  Fly   262 DHRLLMLLSKHMNFRFKYIEAPGRTQGSMRSEDGKDSNDSFTGGIGLLQSGQADFFLGDVGLSWE 326
            ....|:...||                      ||..:..:.|.:|.:...:||..:|.:.::.|
Zfish   504 YDLYLVTNGKH----------------------GKKIDGVWNGMVGEVVYKRADMAIGSLTINEE 546

  Fly   327 RRKAIEFSF------FTLADSGAFATHAPRRLNEALAIMRPFKQDIWPHLI---LTII------- 375
            |.:.::||.      .::..|.:..|.:|.      |.:.|:...:|..:.   ||::
Zfish   547 RSEVVDFSVPFVETGISVMVSRSNGTVSPS------AFLEPYSPAVWVMMFVMCLTVVAVTVFIF 605

  Fly   376 -FSGPIFYGIIALPYIWRRRWANSDVEHLGELYIHMTYLKEITPRLLKLKPRTVLSAHQMPHQLF 439
             |..|:.|.                                          |::.|..:.....|
Zfish   606 EFFSPVGYN------------------------------------------RSLQSGKKAGGSKF 628

  Fly   440 Q--KCIWFTLRLFLKQSCN-ELHNGYRAKFLTIVYWIAATYVLADVYSAQLTSQFARPAREPPIN 501
            .  |.||....|....|.. |...|..:|.:.:|:...|...||. |:|.|.   |...:|..|:
Zfish   629 TIGKSIWLLWALVFNNSVPVENPKGTTSKIMVLVWAFFAVIFLAS-YTANLA---AFMIQEEYID 689

  Fly   502 TLQRLQAAMIHDGYRLYVEKESSSLEMLENGT--ELFRQLYALMRQQVINDPQGFFIDSVEAGIK 564
            |:..|...........|...:..:   :.||:  :..|..|..|.|.::...|    .|||..|.
Zfish   690 TVSGLSDKKFQHPTEQYPPLKFGT---VPNGSTEKNIRSNYPDMHQYMVKYNQ----KSVEDAIS 747

  Fly   565 LIAEGGED 572
            .:..|..|
Zfish   748 HLKTGKLD 755

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir40a	NP_610140.4	PBP2_LTTR_substrate	216..338	CDD:330233	24/127 (19%)
		Periplasmic_Binding_Protein_Type_2	297..>391	CDD:328725	20/110 (18%)
		Periplasmic_Binding_Protein_Type_2	<496..637	CDD:328725	18/79 (23%)
LOC100149482	XP_009290417.1	PBP1_iGluR_NMDA_NR2	44..421	CDD:107373	2/5 (40%)
		PBP2_iGluR_NMDA_Nr2	433..831	CDD:270436	86/445 (19%)
		HisJ	<487..>570	CDD:223904	22/112 (20%)
		Lig_chan	585..857	CDD:278489	43/224 (19%)
		NMDAR2_C	868..>900	CDD:287527
		FAM76	<1763..>1856	CDD:292665
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591620
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.930