Protein Alignment Ir40a and gria3

DIOPT Version :10

• Sequence 1: NP_610140.4
• Gene: Ir40a / 35449
• FlyBaseID: FBgn0259683
• Length: 732
• Species: Drosophila melanogaster
• Sequence 2: NP_001106494.1
• Gene: gria3 / 100127683
• XenbaseID: XB-GENE-1010483
• Length: 887
• Species: Xenopus tropicalis
• Alignment Length: 765
• Identity: 144/765 - (18%)
• Similarity: 275/765 - (35%)
• Gaps: 217/765 - (28%)

  Fly    64 QKERNVYLDDFLQRLHRSNYKSVVFSQTELFFQHIEENL------------QGANECISLILDEP 116
            ::|:...:|..::|::....:.|:..:....:.::..||            .|||.....|::..
 Frog   206 RQEKRFVIDCEVERINTILEQVVILGKHTRGYHYMLANLGFTGFTLERVMHGGANVTGFQIVNNE 270

  Fly   117 NQLLNSLHDRHLGHRLSLFIFYW---GARWPPSSRVIRFREPLR---------VVVVTRPRKKAF 169
            |.::..            |:..|   ..|..|.:|    ..||:         |:|:.    :||
 Frog   271 NPIVQQ------------FLQRWVRLDEREFPEAR----NTPLKYTSALTHDAVLVIA----EAF 315

  Fly   170 RIYYNQ--------------ARPCSDSQLQLVNWYDGDNL--GLQRIPLLPTALSVYANFKGR-- 216
            |....|              |.|.       |.|..|.::  .|:.:.:.....::..:..||
 Frog   316 RYLRRQRVDVSRRGSAGDCLANPA-------VPWSQGIDIERALKMVQVQGMTGNIQFDTYGRRT 373

  Fly   217 TFRVPVFH---SPP-----WFWVTYCNNSFE------EDEEFNSLDSIEKRKVRVT--------- 258
            .:.:.|:.   :.|     |       |.:|      :.:..|...|:|.:.:.||
 Frog   374 NYTIDVYEMTATKPRKVGHW-------NEYERFVPAPDQQPTNESSSVENKTIIVTTILENPYVM 431

  Fly   259 GGRDHRLL--------------MLLSKHMNFRFKYIEAPGRTQGSMRSEDGK-DSNDSFT----G 304
            ..::|.||              ..::||:..::|....          |||| .:.|..|    |
 Frog   432 KKKNHELLDGNDKYEGYCVDLASEIAKHVGIKYKLSIV----------EDGKYGARDPETKIWNG 486

  Fly   305 GIGLLQSGQADFFLGDVGLSWERRKAIEFS--FFTLADSGAFATHAPRRLNEAL-AIMRPFKQDI 366
            .:|.|..|:||..:..:.::..|.:.|:||  |.:|..|  .....|::....: :.:.|...:|
 Frog   487 MVGELVYGRADIAVAPLTITLVREEVIDFSKPFMSLGIS--IMIKKPQKSKPGVFSFLDPLAYEI 549

  Fly   367 WPHLILTIIFSGPIFYGIIAL--------PYIWRRRWANSDVEHLGELYIHMTYLKEITPRLLKL 423
            |    :.|:|:   :.|:..:        ||.|          ||           |.|.
 Frog   550 W----MCIVFA---YIGVSVVLFLVSRFSPYEW----------HL-----------EDTD----- 581

  Fly   424 KPRTVLSAHQMPHQ--LFQKCIWFTLRLFLKQSCNELHNGYRAKFLTIVYWIAATYVLADVYSAQ 486
            :.|...:....|::  :|.. :||:|..|::|.|:........:.:..|:|. .|.::...|:|.
 Frog   582 EARDPQNPPDPPNEFGIFNS-LWFSLGAFMQQGCDISPRSLSGRIVGGVWWF-FTLIIISSYTAN 644

  Fly   487 LTSQFARPAREPPINTLQRLQAAMIHDGYRLYVEKESSSLEMLENGT--ELFRQ----LYALMRQ 545
            |.:.........||.:.:.|            .::...:...|::|:  |.||:    :|..|..
 Frog   645 LAAFLTVERMVSPIESAEDL------------AKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWS 697

  Fly   546 QVINDPQGFFIDSVEAGIKLIAEGGEDKAVLGGRETLFFNVQQYGSNNFQLSQKLYTRYSAVAVQ 610
            .:.:.....|..:.:.|:..:.:.....|.|.......:..|:...:..::...|.::...||..
 Frog   698 YMKSAEPSVFTKTTDDGVARVRKSKGKFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATP 762

  Fly   611 IGCPFLGSLNNVLMQLFESGILDKMTAAEYAKQYQEVEATRIYKGSVQAKNSEAYSRTESYDSTV 675
            .|......:|..:::|.|.|||||:.    .|.:.:       ||...||:|.:..:|
 Frog   763 KGSALGTPVNLAVLKLSEQGILDKLK----NKWWYD-------KGECGAKDSGSKDKT------- 809

  Fly   676 ISPLNLRMLQGAFIALGVGSLA-AGVILLLEIVFIKLDQARLWMLCSRLQ 724
             |.|:|..:.|.|..| ||.|. |.::.|:|..:....:::...|....|
 Frog   810 -SALSLSNVAGVFYIL-VGGLGLAMMVALIEFCYKSRAESKRMKLTKNAQ 857

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir40a	NP_610140.4	Lig_chan-Glu_bd	<265..336	CDD:463166	21/91 (23%)
		Periplasmic_Binding_Protein_Type_2	297..>391	CDD:473866	24/108 (22%)
		Periplasmic_Binding_Protein_Type_2	<496..637	CDD:473866	27/146 (18%)
gria3	NP_001106494.1	PBP1_iGluR_AMPA_GluR3	29..403	CDD:380610	37/230 (16%)
		PBP2_iGluR_AMPA	416..798	CDD:270433	86/451 (19%)