Protein Alignment Ir40a and grin2ca

DIOPT Version :9

• Sequence 1: NP_610140.4
• Gene: Ir40a / 35449
• FlyBaseID: FBgn0259683
• Length: 732
• Species: Drosophila melanogaster
• Sequence 2: NP_001352716.1
• Gene: grin2ca / 100003342
• ZFINID: ZDB-GENE-070822-3
• Length: 1400
• Species: Danio rerio
• Alignment Length: 805
• Identity: 148/805 - (18%)
• Similarity: 259/805 - (32%)
• Gaps: 301/805 - (37%)

  Fly    22 LTFIGNDESDTAIALTQIVRGLQQSSLAILALPSLALS--------------------------- 59
            |.:..:||:....::.:.| ||..... |..:||||:.
Zfish   235 LVYCSHDEAQYLFSMAREV-GLVGPGY-IWFIPSLAVGNPNIAPPDSFPVGLISIITDRWKMSLR 297

  Fly    60 ----DGVC---------QKERNVYLDDFLQRLH----RSN---YK---SVVFSQTELFFQHIEEN 101
                |||.         :|:|....|..:..|.    .||   |:   :|.:..|:..|     |
Zfish   298 NRVRDGVAIVVKGVESFRKQRGFIPDGHMDCLSPIRPASNGTLYRHMLNVSWENTDFSF-----N 357

  Fly   102 LQGANECISLILDEPNQLLNSLHDRHLGHRLSLFIFYWGARWPP----SSRVIRFREPLRVVVVT 162
            ..|       .|..|:.::.:| ||             |.:|..    .|.:::.|.|:
Zfish   358 SDG-------YLVNPSMIIITL-DR-------------GRQWDKVGNYESGILQMRYPV------ 395

  Fly   163 RPRKKAFRIYYNQARPCSDSQ-LQLVNWYDGDNLGLQRI-PLLPTALS--VYANFKGRTFRVPVF 223
            .||...|      ..|.||:: |.:....:...:.::.: |:..|.||  |....:.......|.
Zfish   396 WPRYGTF------LEPVSDNRHLTVATLEERPFVIVEAVDPVTGTCLSNTVPCRRQSNKTETIVG 454

  Fly   224 HSPPWFWVTYCNNSFEEDEEFNSLDSIEKRKVRVTGGRDHRLLMLLSKHMNFRFK-YIEAPGRTQ 287
            |:.|  :...|...|       .:|.::|                ||:::.|.:. |:...|:
Zfish   455 HTEP--YTKLCCKGF-------CIDILKK----------------LSRNIKFSYDLYLVTNGK-- 492

  Fly   288 GSMRSEDGKDSNDSFTGGIGLLQSGQADFFLGDVGLSWERRKAIEFSFFTLADSGAFATHAPRRL 352
                  .||.....:.|.||.:...:||..:|.:.::.||.:.|:|| ....::|.....|  |.
Zfish   493 ------HGKLVRGIWNGMIGEVFYKRADMAIGSLTINEERSEIIDFS-VPFVETGISVMVA--RS 548

  Fly   353 NEAL---AIMRPFKQDIWPHLI---LTII--------FSGPIFYGIIALPYIWRRRWANSDVEHL 403
            |..:   |.:.|:...:|..:.   ||::        :..|:.|.
Zfish   549 NGTVSPSAFLEPYSPAVWVMMFVMCLTVVAVTVFVFEYCSPVGYN-------------------- 593

  Fly   404 GELYIHMTYLKEITPRLLKLKPRTVLSAHQM--PHQLFQKCIWFTLRLFLKQSCN-ELHNGYRAK 465
                                  |:::||...  |.....|.:|....:....|.. |...|..:|
Zfish   594 ----------------------RSLVSAKDPGGPTFTIGKSVWLLWGIVFNNSVPIENPKGTTSK 636

  Fly   466 FLTIVYWIAATYVLADVYSAQLTS-----------------QFARPARE-PPI--------NTLQ 504
            .:.:|:...|...||. |:|.|.:                 :|.:|..: ||.        :|.:
Zfish   637 IMVLVWAFFAVIFLAS-YTANLAAFMIQEQYIDTVSGLSDKKFQKPQDQYPPFRFGTVPNGSTER 700

  Fly   505 RLQAAMIHDGYRLYVEKESSSLEMLENGTELFRQLYALMRQQVINDPQGFFIDSV--------EA 561
            .:::.        |.|..|..::..:.|.|  ..|.:|...::    ..|..|:.        :.
Zfish   701 NIRSN--------YPEMHSHMVKYNQKGVE--DALNSLKTGKL----DAFIYDAAVLNYMAGKDE 751

  Fly   562 GIKLIAEG-GEDKAVLGGRETLFFNVQQYGSNNFQLSQKLYTRYSAVAVQIGCPFLGSLNNVLMQ 625
            |.||:..| |:..|..|           ||                :|:|....:...::..|:|
Zfish   752 GCKLVTIGSGKVFATTG-----------YG----------------IALQKESRWKRPIDLALLQ 789

  Fly   626 LFESGILDKMTAAEYAKQYQEVEATRIYKGSVQAKNSEAYSRTESYDSTVISPLNLRMLQGAFIA 690
            ....|...|:         |.|..|    |..:.:..|..|          |.|::..:.|.|..
Zfish   790 FLADGDTQKL---------QTVWLT----GICRNEKKEVMS----------SKLDIDNMAGVFYM 831

  Fly   691 LGVGSLAAGVILLL----EIVFIKL 711
            |.|   |.|:.||:    .:::.||
Zfish   832 LLV---AMGLSLLVFAWEHLLYWKL 853

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir40a	NP_610140.4	PBP2_LTTR_substrate	216..338	CDD:330233	25/122 (20%)
		Periplasmic_Binding_Protein_Type_2	297..>391	CDD:328725	22/107 (21%)
		Periplasmic_Binding_Protein_Type_2	<496..637	CDD:328725	27/158 (17%)
grin2ca	NP_001352716.1	PBP1_iGluR_NMDA_NR2	38..398	CDD:107373	36/196 (18%)
		PBP2_iGluR_NMDA_Nr2	409..810	CDD:270436	92/533 (17%)
		NMDAR2_C	847..>938	CDD:313729	2/7 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591636
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.930