DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3635 and YEH1

DIOPT Version :9

Sequence 1:	NP_610138.4	Gene:	CG3635 / 35447	FlyBaseID:	FBgn0032981	Length:	425	Species:	Drosophila melanogaster
Sequence 2:	NP_013089.1	Gene:	YEH1 / 850648	SGDID:	S000003935	Length:	573	Species:	Saccharomyces cerevisiae

Alignment Length:	460	Identity:	108/460 - (23%)
Similarity:	187/460 - (40%)	Gaps:	99/460 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 NNSCAQTNILTSKEMANNSPTRGSVMLL---TLVLLLLSRKIGLVDGHKVTATSISNHNYPVEEH 65
            |||        |.|:||:.|....:.:.   .|..|:||..:.||.....   ..:.:|..:||.
Yeast   139 NNS--------SNEIANHEPVFEKIPVQCDNPLQNLILSEDLTLVADLNY---YFNQYNIQIEEF 192

  Fly    66 TVITHDDYILTI------YRIPSSPNRSHLNRAGRRAVVFLQHGILSASDDWIINGPEASLAYML 124
            .:.|.|.:::.:      ||...|..:       :|..:.:.||:|.:|..:..|| ..||||.|
Yeast   193 RLETEDGFVIDLWHLIPKYRTTDSDKK-------KRPPILMLHGLLQSSGSFASNG-RKSLAYFL 249

  Fly   125 ADAGYDVWLGNARGNTYSRQHKHIHPDTSDFWRFSWHEIGVYDLAAMLDYALAKSQSSSLHFVAH 189
            ..:|||:||||.|.......::...|..:..|.:...|:..|||..::|..|||:|...|..::|
Yeast   250 YQSGYDIWLGNNRCGFRPEWNEAKVPTLASRWDWDLREMVKYDLTLLIDTVLAKTQFEKLTLISH 314

  Fly   190 SQGTTAFFVLM------------SSLPLYNEKLRSVHLLAPIAY----MRDHSFILSKLGGIFLG 238
            |||||..|:.:            |....:..|:.:...|||..|    :.:..|:  ||....:.
Yeast   315 SQGTTQGFMGLVNEDKFFPPGSGSKESFFTSKIANYIALAPAVYPGPLLNEKLFV--KLMTKEIE 377

  Fly   239 TPSFLSWVLGSMELLPITNLQKLICEHICSSSSMFNFLCSGLLDFIGGWGTRHLNQTLLPDVCAT 303
            .|    |..|......|    .:|..::|...|:|:|:|..:.:::..|     |.||.......
Yeast   378 NP----WFFGETSFFEI----MMIVRNLCVGESLFSFVCYTIFNYLFDW-----NDTLWDTALRD 429

  Fly   304 HPAGASSSQVIHYL--QLYRSGDFRQYDHGPELNEIIYQQPTPPSY--NVQYIKSC--------- 355
            .          |:|  .::.|....|:...|:.|::.::..:...:  ||::....
Yeast   430 R----------HFLFSPVHVSVKLMQWWLSPDPNKVSFKFGSHKMFPDNVKWFSDASKAPNIYLF 484

  Fly   356 -------VDMYYSENDYMSAVGDVKYLASLLPCAQLYRIPFRDWNHYDFLWSNNVKEVINNKIIQ 413
                   ||.....|.:::...:|.|        :::.|.  ::.|.|.||:::|.|.|...|:|
Yeast   485 VPKQDRLVDGERLINHFVNVESNVNY--------KIWYID--EYAHIDVLWAHDVIERIGKPILQ 539

  Fly   414 KIRKY 418
            .:..|
Yeast   540 NLNNY 544

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3635	NP_610138.4	Abhydro_lipase	55..115	CDD:282003	13/65 (20%)
CG3635	NP_610138.4	Abhydrolase_1	97..399	CDD:278959	77/337 (23%)
YEH1	NP_013089.1	PLN02872	169..>326	CDD:215470	50/167 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157341626
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2624
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0.977872	Normalized mean entropy	S1866
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.690