DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3635 and LIPN

DIOPT Version :9

Sequence 1:	NP_610138.4	Gene:	CG3635 / 35447	FlyBaseID:	FBgn0032981	Length:	425	Species:	Drosophila melanogaster
Sequence 2:	NP_001095939.1	Gene:	LIPN / 643418	HGNCID:	23452	Length:	398	Species:	Homo sapiens

Alignment Length:	370	Identity:	118/370 - (31%)
Similarity:	198/370 - (53%)	Gaps:	10/370 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 TATSISNHNYPVEEHTVITHDDYILTIYRIPSSPNRSHLNRAGRRAVVFLQHGILSASDDWIING 115
            |:..|..:.||.||:.|.|.|.|||.:.|||.  .|:|....|.|.||::||.:.:.:..|:.|.
Human    36 TSEIIIYNGYPSEEYEVTTEDGYILLVNRIPY--GRTHARSTGPRPVVYMQHALFADNAYWLENY 98

  Fly   116 PEASLAYMLADAGYDVWLGNARGNTYSRQHKHIHPDTSDFWRFSWHEIGVYDLAAMLDYALAKSQ 180
            ...||.::|||||||||:||:||||:||:||.:......||.||:.|:..|||..::|:.:.|:.
Human    99 ANGSLGFLLADAGYDVWMGNSRGNTWSRRHKTLSETDEKFWAFSFDEMAKYDLPGVIDFIVNKTG 163

  Fly   181 SSSLHFVAHSQGTTAFFVLMSSLPLYNEKLRSVHLLAPIAYMRDHSFILSKLGGIFLGTPSFLSW 245
            ...|:|:.||.|||..||..|::|...::::....|.|....:..:.|.::   .||...|.:..
Human   164 QEKLYFIGHSLGTTIGFVAFSTMPELAQRIKMNFALGPTISFKYPTGIFTR---FFLLPNSIIKA 225

  Fly   246 VLGSMELLPITNLQKLICEHICSSSSMFNFLCSGLLDFIGGWGTRHLNQTLLPDVCATH-PAGAS 309
            |.|:..........|:....||::..:: .:||..:....|...:::||:.: ||..:| |.|:|
Human   226 VFGTKGFFLEDKKTKIASTKICNNKILW-LICSEFMSLWAGSNKKNMNQSRM-DVYMSHAPTGSS 288

  Fly   310 SSQVIHYLQLYRSGDFRQYDHGPELNEI-IYQQPTPPSYNVQYIKSCVDMYYSENDYMSAVGDVK 373
            ...::|..|||.|.:||.||.|.:.:.: .|.|..||.|::..:|....::...:|.:....||.
Human   289 VHNILHIKQLYHSDEFRAYDWGNDADNMKHYNQSHPPIYDLTAMKVPTAIWAGGHDVLVTPQDVA 353

  Fly   374 YLASLLPCAQLYRIPFRDWNHYDFLWSNNVKEVINNKIIQKIRKY 418
            .:...:.....::: ..||||:||:|..:..:.:.::||..::.|
Human   354 RILPQIKSLHYFKL-LPDWNHFDFVWGLDAPQRMYSEIIALMKAY 397

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3635	NP_610138.4	Abhydro_lipase	55..115	CDD:282003	23/59 (39%)
CG3635	NP_610138.4	Abhydrolase_1	97..399	CDD:278959	95/303 (31%)
LIPN	NP_001095939.1	Abhydro_lipase	36..97	CDD:282003	24/62 (39%)
		Abhydrolase_1	79..379	CDD:278959	95/305 (31%)
		Abhydrolase	106..>175	CDD:304388	33/68 (49%)
		Abhydrolase	<149..>234	CDD:304388	24/87 (28%)
		Abhydrolase_5	<322..374	CDD:289465	10/52 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141746
Domainoid	1	1.000	222	1.000	Domainoid score	I2592
eggNOG	1	0.900	-	-		E2759_KOG2624
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	271	1.000	Inparanoid score	I3005
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55134
OrthoDB	1	1.010	-	-		D408561at33208
OrthoFinder	1	1.000	-	-		FOG0000083
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11005
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X80
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	12	11.910