DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3635 and lipa

DIOPT Version :9

Sequence 1:	NP_610138.4	Gene:	CG3635 / 35447	FlyBaseID:	FBgn0032981	Length:	425	Species:	Drosophila melanogaster
Sequence 2:	NP_001015847.2	Gene:	lipa / 548564	XenbaseID:	XB-GENE-952977	Length:	409	Species:	Xenopus tropicalis

Alignment Length:	422	Identity:	148/422 - (35%)
Similarity:	226/422 - (53%)	Gaps:	41/422 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 SPTRGSVMLLTLVLLLLSRKIGLVDG------HKVT----------ATS-----ISNHNYPVEEH 65
            |||    |.|.:.:..|...:.|.|.      |.|.          ||.     |....||.||:
Frog     3 SPT----MWLLVAVTALIPAVALTDDVPSRIRHGVAGDLLYSADPEATMNISELIRYRGYPSEEY 63

  Fly    66 TVITHDDYILTIYRIPSSPNRSHLNRAGRRAVVFLQHGILSASDDWIINGPEASLAYMLADAGYD 130
            .|:|.|.|||::.|||.....:   ..|.:.|||||||:|:...:|:.|....||.::|||||||
Frog    64 EVLTEDGYILSVNRIPHGVKYA---SEGPKPVVFLQHGLLADGSNWVTNLENNSLGFILADAGYD 125

  Fly   131 VWLGNARGNTYSRQHKHIHPDTSDFWRFSWHEIGVYDLAAMLDYALAKSQSSSLHFVAHSQGTTA 195
            ||:||:||||:||:||.:.||..:||.||:.|:...||.|::|:...|:....:.:|.||||||.
Frog   126 VWIGNSRGNTWSRKHKSLSPDQEEFWAFSYDELAKKDLPAVVDFITKKTGQEQIFYVGHSQGTTI 190

  Fly   196 FFVLMSSLPLYNEKLRSVHLLAPIAYMRDHSFILSKLGGIFLGTPSFL-SWVLGSMELLPITNLQ 259
            .|:..||||...:|::....|||:|.::.....|:|||.:    |.|| ..:.|..|.||.|.|.
Frog   191 AFIAFSSLPQLAKKIKMYFGLAPVATVKFSKSPLAKLGVL----PEFLIEELFGKGEFLPQTYLI 251

  Fly   260 KLICEHICSSSSMFNFLCSGLLDFIGGWGTRHLNQTLLPDVCATH-PAGASSSQVIHYLQLYRSG 323
            ..:..|.| :.::.:.||..:...:.|:..::||.:.: :|.::| |||.|...::|:.|..|||
Frog   252 TWLATHFC-THAIADELCGNIFFLLSGFNEKNLNMSRV-NVYSSHCPAGTSVQNMLHWRQGVRSG 314

  Fly   324 DFRQYDHGPELNEIIYQQPTPPSYNVQYIKSCVDMYYSENDYMSAVGDVKYLASLLPCAQ--LYR 386
            :.:.:|.|.:.|.|.|.|.|||.|:|:.:.....::...||:::   |.|.:|.||....  :|.
Frog   315 ELKAFDFGTKGNMIHYNQTTPPFYHVRDMTVPTALWTGGNDWLA---DRKDVALLLTQVSNLVYH 376

  Fly   387 IPFRDWNHYDFLWSNNVKEVINNKIIQKIRKY 418
            ....||.|.||:|..:..|.:.|:||..::|:
Frog   377 KEIPDWEHLDFIWGLDAPERMYNEIIAMMKKF 408

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3635	NP_610138.4	Abhydro_lipase	55..115	CDD:282003	24/59 (41%)
CG3635	NP_610138.4	Abhydrolase_1	97..399	CDD:278959	115/305 (38%)
lipa	NP_001015847.2	Abhydro_lipase	49..110	CDD:282003	24/63 (38%)
		PLN02872	50..409	CDD:215470	136/371 (37%)
		Abhydrolase_5	91..>229	CDD:289465	63/137 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	274	1.000	Inparanoid score	I2899
OMA	1	1.010	-	-		QHG55134
OrthoDB	1	1.010	-	-		D408561at33208
OrthoFinder	1	1.000	-	-		FOG0000083
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR11005
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X80
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.080