Protein Alignment CG3635 and LIPA

DIOPT Version :9

• Sequence 1: NP_610138.4
• Gene: CG3635 / 35447
• FlyBaseID: FBgn0032981
• Length: 425
• Species: Drosophila melanogaster
• Sequence 2: NP_000226.2
• Gene: LIPA / 3988
• HGNCID: 6617
• Length: 399
• Species: Homo sapiens
• Alignment Length: 408
• Identity: 138/408 - (33%)
• Similarity: 217/408 - (53%)
• Gaps: 42/408 - (10%)

  Fly    40 RKIGLV------------DGHKVTATS----------ISNHNYPVEEHTVITHDDYILTIYRIPS 82
            |.:|||            .|.|:||..          ||...:|.||:.|.|.|.|||.:.|||.
Human     4 RFLGLVVCLVLWTLHSEGSGGKLTAVDPETNMNVSEIISYWGFPSEEYLVETEDGYILCLNRIPH 68

  Fly    83 SPNRSHLNRAGRRAVVFLQHGILSASDDWIINGPEASLAYMLADAGYDVWLGNARGNTYSRQHKH 147
            . .::|.:: |.:.|||||||:|:.|.:|:.|...:||.::|||||:|||:||:||||:||:||.
Human    69 G-RKNHSDK-GPKPVVFLQHGLLADSSNWVTNLANSSLGFILADAGFDVWMGNSRGNTWSRKHKT 131

  Fly   148 IHPDTSDFWRFSWHEIGVYDLAAMLDYALAKSQSSSLHFVAHSQGTTAFFVLMSSLPLYNEKLRS 212
            :.....:||.||:.|:..|||.|.:::.|.|:....:::|.||||||..|:..|.:|...::::.
Human   132 LSVSQDEFWAFSYDEMAKYDLPASINFILNKTGQEQVYYVGHSQGTTIGFIAFSQIPELAKRIKM 196

  Fly   213 VHLLAPIAYMRDHSFILSKLGGIFLGTPSFL-SWVLGSMELLPITNLQKLICEHICSSSSMFNFL 276
            ...|.|:|.:...:..::|||.:    |..| ..:.|..|.||.:...|.:..|:| :..:...|
Human   197 FFALGPVASVAFCTSPMAKLGRL----PDHLIKDLFGDKEFLPQSAFLKWLGTHVC-THVILKEL 256

  Fly   277 CSGLLDFIGGWGTRHLNQTLLPDVCATH-PAGASSSQVIHYLQLYRSGDFRQYDHGPEL-NEIIY 339
            |..|...:.|:..|:||.:.: ||..|| |||.|...::|:.|..:...|:.:|.|... |...|
Human   257 CGNLCFLLCGFNERNLNMSRV-DVYTTHSPAGTSVQNMLHWSQAVKFQKFQAFDWGSSAKNYFHY 320

  Fly   340 QQPTPPSYNVQYIKSCVDMYYSENDYMSAVGDVKYLASLLPCAQLYRIPFR----DWNHYDFLWS 400
            .|..||:|||:.:.....::...:|:::.|.||..|.:     |:..:.|.    :|.|.||:|.
Human   321 NQSYPPTYNVKDMLVPTAVWSGGHDWLADVYDVNILLT-----QITNLVFHESIPEWEHLDFIWG 380

  Fly   401 NNVKEVINNKIIQKIRKY 418
            .:....:.||||..:|||
Human   381 LDAPWRLYNKIINLMRKY 398

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG3635	NP_610138.4	Abhydro_lipase	55..115	CDD:282003	26/59 (44%)
		Abhydrolase_1	97..399	CDD:278959	106/308 (34%)
LIPA	NP_000226.2	PLN02872	38..396	CDD:215470	127/370 (34%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141790
Domainoid	1	1.000	222	1.000	Domainoid score	I2592
eggNOG	1	0.900	-	-		E2759_KOG2624
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	271	1.000	Inparanoid score	I3005
Isobase	1	0.950	-	0.977872	Normalized mean entropy	S1866
OMA	1	1.010	-	-		QHG55134
OrthoDB	1	1.010	-	-		D408561at33208
OrthoFinder	1	1.000	-	-		FOG0000083
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR11005
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X80
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	12	11.860