DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3635 and Lipo1

DIOPT Version :9

Sequence 1:	NP_610138.4	Gene:	CG3635 / 35447	FlyBaseID:	FBgn0032981	Length:	425	Species:	Drosophila melanogaster
Sequence 2:	XP_006231364.1	Gene:	Lipo1 / 294097	RGDID:	1565682	Length:	397	Species:	Rattus norvegicus

Alignment Length:	408	Identity:	132/408 - (32%)
Similarity:	217/408 - (53%)	Gaps:	34/408 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 MLLTLVLLLLSRKIGLV-------DGHKVTATSISNHNYPVEEHTVITHDDYILTIYRIPSSPNR 86
            :|.|:.|:.:..||..:       :.|...:..|...|||..|:.|:|.|.|||.|.|||...|.
  Rat     4 LLRTMCLIHVFGKIFCLLEPNKNPESHMNVSEIIKYWNYPSLEYEVVTDDGYILPINRIPHGKNN 68

  Fly    87 SHLNRAGRRAVVFLQHGILSASDDWIINGPEASLAYMLADAGYDVWLGNARGNTYSRQHKHIHPD 151
            :  |.:..:.|||.|||:.|....|:.|.|:.|||::||:|||||||||:||:|::::|..:.||
  Rat    69 A--NSSAPKMVVFCQHGLFSTPGVWVANPPDNSLAFILAEAGYDVWLGNSRGSTWAKKHVTLSPD 131

  Fly   152 TSDFWRFSWHEIGVYDLAAMLDYALAKSQSSSLHFVAHSQGTTAFFVLMSSLPLYNEKLRSVHLL 216
            :.:||.||:.::..|||.|.:::.|..:....::::.||.||.......|:.....||::...|:
  Rat   132 SEEFWAFSFDQMIAYDLPATINFILNTTGQEQIYYIGHSLGTLIALGAFSTNQELAEKIKLNILI 196

  Fly   217 AP---IAYMRDHSFILSKLGGIFLGTPSFLSWVLGSMELLP---ITNLQKLICEHICSSSSMFNF 275
            ||   :.|::....:|:..      :|.....|.|..|.||   .:...|.:|     :..:.:.
  Rat   197 APVRTVKYVKGFGRLLAYF------SPEAFKLVFGKKEFLPTVVFSEYSKYVC-----NIKLVDA 250

  Fly   276 LCSGLLDFIGGWGTRHLNQTLLPDVCATHP-AGASSSQVIHYLQLYRSGDFRQYDHG-PELNEII 338
            .|:|:|..:.|:....||.:.: ||..||. ||.|:..:||..|..|||:|:.||.| |.||...
  Rat   251 GCAGVLGSLTGFSEDQLNTSRI-DVYITHSLAGTSTQILIHAGQAIRSGEFQAYDWGSPSLNMQH 314

  Fly   339 YQQPTPPSYNVQYIKSCVDMYYSENDYMSAVGDVKYLASLLP--CAQLYRIPFRDWNHYDFLWSN 401
            |.|.|||.|:|:.:|....|:....|:::   |.|.:|:|:|  ...:|.....:::|.||:...
  Rat   315 YNQTTPPLYSVENMKVPTVMFTGLKDFLA---DPKDVANLVPKIFNLIYHKTIPEFSHLDFIVGL 376

  Fly   402 NVKEVINNKIIQKIRKYD 419
            |.|..::::|:..:.:||
  Rat   377 NAKTEVSDEILTILGEYD 394

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3635	NP_610138.4	Abhydro_lipase	55..115	CDD:282003	25/59 (42%)
CG3635	NP_610138.4	Abhydrolase_1	97..399	CDD:278959	104/311 (33%)
Lipo1	XP_006231364.1	Abhydro_lipase	33..94	CDD:282003	25/62 (40%)
		Abhydrolase_1	77..375	CDD:278959	104/312 (33%)
		Abhydrolase_5	77..>199	CDD:289465	48/121 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166335462
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2624
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	272	1.000	Inparanoid score	I2916
OMA	1	1.010	-	-		QHG55134
OrthoDB	1	1.010	-	-		D408561at33208
OrthoFinder	1	1.000	-	-		FOG0000083
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11005
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X80
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.910