DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3635 and Lipa

DIOPT Version :9

Sequence 1:	NP_610138.4	Gene:	CG3635 / 35447	FlyBaseID:	FBgn0032981	Length:	425	Species:	Drosophila melanogaster
Sequence 2:	NP_001104570.1	Gene:	Lipa / 16889	MGIID:	96789	Length:	397	Species:	Mus musculus

Alignment Length:	402	Identity:	134/402 - (33%)
Similarity:	224/402 - (55%)	Gaps:	17/402 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 RGSVMLLTLVLLLLSRKIGLVD------GHKVTATSISNHNYPVEEHTVITHDDYILTIYRIPSS 83
            :|.|.:.|:.:||.....|.|.      ...||.. |....||.|||:|:|.|.|||:|:|||..
Mouse     4 QGLVFVFTIGILLSRVPTGTVSAVDPEVNMNVTEI-IMRWGYPGEEHSVLTGDGYILSIHRIPRG 67

  Fly    84 PNRSHLNRAGRRAVVFLQHGILSASDDWIINGPEASLAYMLADAGYDVWLGNARGNTYSRQHKHI 148
             .::|..: |.|.||:||||:|:.|.:|:.|...:||.::|||||:|||:||:||||:|.:||.:
Mouse    68 -RKNHFGK-GPRPVVYLQHGLLADSSNWVTNIDNSSLGFLLADAGFDVWMGNSRGNTWSLKHKTL 130

  Fly   149 HPDTSDFWRFSWHEIGVYDLAAMLDYALAKSQSSSLHFVAHSQGTTAFFVLMSSLPLYNEKLRSV 213
            .....:||.||:.|:..|||.|.::|.|.|:....:::|.||||.|..|:..|.:|...:|::..
Mouse   131 SVSQDEFWAFSFDEMAKYDLPASINYILNKTGQEQIYYVGHSQGCTIGFIAFSQMPELAKKIKMF 195

  Fly   214 HLLAPIAYMRDHSFILSKLGGIFLGTPSFLSWVLGSMELLPITNLQKLICEHICSSSSMFNFLCS 278
            .:|||:..:...|..|.:||.:   ....|..:.|..:.||.:.:.|.:..|:|:...| ..||:
Mouse   196 LVLAPVLSLNFASGPLLQLGRL---PDPLLKDMFGQKQFLPQSAMLKWLSIHVCTHVIM-KELCA 256

  Fly   279 GLLDFIGGWGTRHLNQTLLPDVCATH-PAGASSSQVIHYLQLYRSGDFRQYDHG-PELNEIIYQQ 341
            .:...:.|:..::||.:.: ||..|| |||.|...::|:.|:::....:.:|.| .|.|...|.|
Mouse   257 NVFFLLCGFNEKNLNMSRV-DVYTTHCPAGTSVQNMLHWGQVFKYRKLQAFDWGSSEKNYFHYNQ 320

  Fly   342 PTPPSYNVQYIKSCVDMYYSENDYMSAVGDVKYLASLLPCAQLYRIPFRDWNHYDFLWSNNVKEV 406
            ..|||||::.::....::....|:::.:.|:..|.:.:| ..:|.....:|:|.||:|..:....
Mouse   321 SFPPSYNIKNMRLPTALWSGGRDWLADINDITILLTQIP-KLVYHKNIPEWDHLDFIWGLDAPWK 384

  Fly   407 INNKIIQKIRKY 418
            :.::||..::||
Mouse   385 LYDEIISLMKKY 396

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3635	NP_610138.4	Abhydro_lipase	55..115	CDD:282003	28/59 (47%)
CG3635	NP_610138.4	Abhydrolase_1	97..399	CDD:278959	101/303 (33%)
Lipa	NP_001104570.1	PLN02872	6..394	CDD:215470	131/396 (33%)
		Abhydro_lipase	35..96	CDD:282003	30/63 (48%)
		Abhydrolase_5	78..>192	CDD:289465	50/113 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831792
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2624
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0.977872	Normalized mean entropy	S1866
OMA	1	1.010	-	-		QHG55134
OrthoDB	1	1.010	-	-		D408561at33208
OrthoFinder	1	1.000	-	-		FOG0000083
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR11005
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X80
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.810