Protein Alignment Clamp and ZNF614

DIOPT Version :10

• Sequence 1: NP_001014498.1
• Gene: Clamp / 35445
• FlyBaseID: FBgn0032979
• Length: 566
• Species: Drosophila melanogaster
• Sequence 2: NP_079316.2
• Gene: ZNF614 / 80110
• HGNCID: 24722
• Length: 585
• Species: Homo sapiens
• Alignment Length: 570
• Identity: 146/570 - (25%)
• Similarity: 237/570 - (41%)
• Gaps: 136/570 - (23%)

  Fly    60 LAQLA------TTD---DNKTCYIAQPVGGYNYALVNGMPLNQGAALGIATVDAQGRIQ-IVNQN 114
            |::||      |||   .||.|   ..:|..:..|....| ||.....:...:.|..:: ||:.:
Human    57 LSKLAHGQEPWTTDAKIQNKNC---PGIGKVDSHLQEHSP-NQRLLKSVQQCNGQNTLRNIVHLS 117

  Fly   115 K---PIAANTISNISFKCDVCSDMFPHLALLNAHKRMH--------TDGEQ-----QQQQQHNAQ 163
            |   ||..|..:...::.::.|.    |:|:| .||.|        ..||:     :.::.|...
Human   118 KTHFPIVQNHDTFDLYRKNLKSS----LSLIN-QKRRHGINNPVEFIGGEKTLLHGKHERTHTKT 177

  Fly   164 AGGDSIAVVSAQGLVQAQNIIGNGQMGQIQIVSSDTLEPVQQSVMQQQQHESKASKCINCGSSML 228
            ...::...:..                :.|:...           |:.|...|...||.|..:.|
Human   178 RFSENAKCIHT----------------KFQVFKH-----------QRTQKIEKPHACIECEQTFL 215

  Fly   229 QQSK---------RKGPKQVRCESCMQA-----EQTAQQQQQLFVAQDGQMAHPVQ-IISTTPQA 278
            ::|:         ::.|...:||...::     ........::.:..:.:....|: .:.|..|.
Human   216 RKSQLIYHENICIQENPGSGQCEKLSRSVLFTKHLKTNTTDKICIPNEYRKGSTVKSSLITHQQT 280

  Fly   279 QAQLQQIVAAQTG-GTTPKR----EASSGSGHHPVKKRNSQQMTKCQKCNGSGV-----VLVGQH 333
            ..:.:..:.::.| |.|.||    ...:.||..|.         .|::| |.|.     ::|.|.
Human   281 HTEEKSYMCSECGKGFTMKRYLIAHQRTHSGEKPY---------VCKEC-GKGFTVKSNLIVHQR 335

  Fly   334 SH-------ASHSGVGGSVKQSVTVKTECLSCRNPSKPFSCNICGGLFSRYSSLWSHKKLHSGEK 391
            :|       .|..|.|.::|:.:.|...   .....||:.|:.||..|:..|:|..|::.|:|||
Human   336 THTGEKPYICSECGKGFTMKRYLVVHQR---THTGEKPYMCSECGKGFTVKSNLIVHQRSHTGEK 397

  Fly   392 NYKCSICGLAF--------------AKAVYLKN--------------HARIHTGEKPYKCQTCGM 428
            :|.||.||..|              .:..|:.|              |.|.|||||||:|..||.
Human   398 SYICSECGKGFTVKRTLVIHQRTHTGEKSYICNECGKGFTTKRTLIIHQRTHTGEKPYECNECGK 462

  Fly   429 QFSQSPHLKNHERTHSGERPYVCGVCDKGFARHATLWNHRRIHTGEKPYKCEICGSAFSQAAHLK 493
            .|||...|..|||.|:|:.|:||..|.|.::....|..|:|||||||||:|..||.||:..:.|.
Human   463 AFSQKICLIQHERCHTGKTPFVCTECGKSYSHKYGLITHQRIHTGEKPYECNECGKAFTTKSVLN 527

  Fly   494 NHAKVHSGEKPYKCEICSAAFADRFALKRHRGIH-QKYGQTAPRQTSSDG 542
            .|.:.|:||:||.|..|..||:....|.:|:.:| ::.|:.:..:.|.:|
Human   528 VHQRTHTGERPYGCSDCEKAFSHLSNLVKHKKMHTREMGRISQVENSCNG 577

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Clamp	NP_001014498.1	COG5048	<359..498	CDD:227381	65/166 (39%)
		C2H2 Zn finger	367..387	CDD:275368	7/19 (37%)
		C2H2 Zn finger	395..415	CDD:275368	9/47 (19%)
		zf-H2C2_2	407..432	CDD:463886	15/38 (39%)
		C2H2 Zn finger	423..443	CDD:275368	10/19 (53%)
		C2H2 Zn finger	451..471	CDD:275368	6/19 (32%)
		COG5048	475..>529	CDD:227381	22/54 (41%)
		C2H2 Zn finger	479..499	CDD:275368	7/19 (37%)
		C2H2 Zn finger	507..527	CDD:275368	6/19 (32%)
ZNF614	NP_079316.2	KRAB	8..68	CDD:214630	3/10 (30%)
		COG5048	<92..350	CDD:227381	51/300 (17%)
		C2H2 Zn finger	207..226	CDD:275370	5/18 (28%)
		C2H2 Zn finger	236..253	CDD:275368	2/16 (13%)
		C2H2 Zn finger	289..309	CDD:275368	5/19 (26%)
		C2H2 Zn finger	317..337	CDD:275368	6/20 (30%)
		C2H2 Zn finger	345..365	CDD:275368	5/22 (23%)
		COG5048	<369..530	CDD:227381	64/160 (40%)
		C2H2 Zn finger	373..393	CDD:275368	7/19 (37%)
		C2H2 Zn finger	401..421	CDD:275368	5/19 (26%)
		C2H2 Zn finger	429..449	CDD:275368	3/19 (16%)
		C2H2 Zn finger	457..477	CDD:275368	10/19 (53%)
		C2H2 Zn finger	485..505	CDD:275368	6/19 (32%)
		C2H2 Zn finger	513..533	CDD:275368	7/19 (37%)
		C2H2 Zn finger	541..561	CDD:275368	6/19 (32%)