DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Clamp and ZNF229

DIOPT Version :9

Sequence 1:	NP_001014498.1	Gene:	Clamp / 35445	FlyBaseID:	FBgn0032979	Length:	566	Species:	Drosophila melanogaster
Sequence 2:	NP_055333.3	Gene:	ZNF229 / 7772	HGNCID:	13022	Length:	825	Species:	Homo sapiens

Alignment Length:	467	Identity:	139/467 - (29%)
Similarity:	199/467 - (42%)	Gaps:	130/467 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    92 NQGAALGIATVDAQGRIQIVNQNKPIAAN---TISNISFKCDVCSDMFPHLALLNAHKRMHTDGE 153
            :|....|..:|.:..|.:.|.||..|..:   .:.::.::||||...|.:.::|..|:.:|| |.
Human   311 HQRVPTGEKSVKSLERGRGVRQNTHIRNHPRAPVGDMPYRCDVCGKGFRYKSVLLIHQGVHT-GR 374

  Fly   154 QQQQQQHNAQAGGDSIAVVSAQGLVQAQNIIGNGQMGQIQIVSSDTLEPVQQSVMQQQQHESKAS 218
            :..:.:...:|.|            ::.|::                      |.|:.....|..
Human   375 RPYKCEECGKAFG------------RSSNLL----------------------VHQRVHTGEKPY 405

  Fly   219 KCINCG-----SSMLQQSKR--KGPKQVRCESCMQ---AEQTAQQQQQLFVAQDGQMAHPVQIIS 273
            ||..||     ||:||..:|  .|.|...|..|.:   |:....:.|.:         ||
Human   406 KCSECGKGFSYSSVLQVHQRLHTGEKPYTCSECGKGFCAKSALHKHQHI---------HP----- 456

  Fly   274 TTPQAQAQLQQIVAAQTGGTTPKREASSGSGHHPVKKRNSQQMT-------KCQKCNGSGV---- 327
                              |..|......|.|.......:|.|.|       :|.|| |.|.
Human   457 ------------------GEKPYSCGECGKGFSCSSHLSSHQKTHTGERPYQCDKC-GKGFSHNS 502

  Fly   328 -------VLVGQHSHASHSGVGGSVKQSVTVKTECLSCRNPSKPFSCNICGGLFSRYSSLWSHKK 385
                   |.:|||.                              :.||:||..||..|.|..|::
Human   503 YLQAHQRVHMGQHL------------------------------YKCNVCGKSFSYSSGLLMHQR 537

  Fly   386 LHSGEKNYKCSICGLAFAKAVYLKNHARIHTGEKPYKCQTCGMQFSQSPHLKNHERTHSGERPYV 450
            ||:|||.|||. ||.:|.::..|..|.|:|||||||||..||..|.::..|.:|:|.|:||||||
Human   538 LHTGEKPYKCE-CGKSFGRSSDLHIHQRVHTGEKPYKCSECGKGFRRNSDLHSHQRVHTGERPYV 601

  Fly   451 CGVCDKGFARHATLWNHRRIHTGEKPYKCEICGSAFSQAAHLKNHAKVHSGEKPYKCEICSAAFA 515
            |.||.|||...:.|..|:|:|||||||||..||..||.::.|..|.:||:|||||:|:.|...|.
Human   602 CDVCGKGFIYSSDLLIHQRVHTGEKPYKCAECGKGFSYSSGLLIHQRVHTGEKPYRCQECGKGFR 666

  Fly   516 DRFALKRHRGIH 527
            ...:|.:|:.:|
Human   667 CTSSLHKHQRVH 678

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Clamp	NP_001014498.1	COG5048	<359..498	CDD:227381	69/138 (50%)
		C2H2 Zn finger	367..387	CDD:275368	9/19 (47%)
		zf-H2C2_2	379..403	CDD:290200	12/23 (52%)
		C2H2 Zn finger	395..415	CDD:275368	7/19 (37%)
		zf-H2C2_2	407..432	CDD:290200	15/24 (63%)
		C2H2 Zn finger	423..443	CDD:275368	7/19 (37%)
		zf-H2C2_2	435..460	CDD:290200	16/24 (67%)
		C2H2 Zn finger	451..471	CDD:275368	9/19 (47%)
		zf-H2C2_2	464..488	CDD:290200	15/23 (65%)
		COG5048	475..>529	CDD:227381	24/53 (45%)
		C2H2 Zn finger	479..499	CDD:275368	7/19 (37%)
		zf-H2C2_2	491..515	CDD:290200	11/23 (48%)
		C2H2 Zn finger	507..527	CDD:275368	5/19 (26%)
ZNF229	NP_055333.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..26
		KRAB	34..>74	CDD:214630
		KRAB	34..73	CDD:279668
		C2H2 Zn finger	351..371	CDD:275368	7/19 (37%)
		COG5048	375..787	CDD:227381	121/402 (30%)
		C2H2 Zn finger	379..399	CDD:275368	5/53 (9%)
		zf-H2C2_2	391..416	CDD:290200	8/46 (17%)
		C2H2 Zn finger	407..427	CDD:275368	8/19 (42%)
		zf-H2C2_2	420..442	CDD:290200	7/21 (33%)
		C2H2 Zn finger	435..455	CDD:275368	4/28 (14%)
		C2H2 Zn finger	463..483	CDD:275368	4/19 (21%)
		zf-H2C2_2	475..500	CDD:290200	8/25 (32%)
		C2H2 Zn finger	491..511	CDD:275368	5/20 (25%)
		C2H2 Zn finger	519..539	CDD:275368	9/19 (47%)
		C2H2 Zn finger	547..566	CDD:275368	7/19 (37%)
		zf-H2C2_2	562..583	CDD:290200	14/20 (70%)
		C2H2 Zn finger	574..594	CDD:275368	7/19 (37%)
		zf-H2C2_2	589..611	CDD:290200	15/21 (71%)
		C2H2 Zn finger	602..622	CDD:275368	9/19 (47%)
		zf-H2C2_2	614..639	CDD:290200	15/24 (63%)
		C2H2 Zn finger	630..650	CDD:275368	7/19 (37%)
		zf-H2C2_2	643..667	CDD:290200	12/23 (52%)
		C2H2 Zn finger	658..678	CDD:275368	5/19 (26%)
		zf-H2C2_2	673..695	CDD:290200	2/6 (33%)
		C2H2 Zn finger	686..706	CDD:275368
		zf-H2C2_2	698..723	CDD:290200
		C2H2 Zn finger	714..734	CDD:275368
		zf-H2C2_2	727..751	CDD:290200
		C2H2 Zn finger	742..762	CDD:275368
		zf-H2C2_2	754..779	CDD:290200
		C2H2 Zn finger	770..790	CDD:275368
		zf-H2C2_2	785..807	CDD:290200
		C2H2 Zn finger	798..818	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000