DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Clamp and ZNF225

DIOPT Version :9

Sequence 1:	NP_001014498.1	Gene:	Clamp / 35445	FlyBaseID:	FBgn0032979	Length:	566	Species:	Drosophila melanogaster
Sequence 2:	NP_001308614.1	Gene:	ZNF225 / 7768	HGNCID:	13018	Length:	706	Species:	Homo sapiens

Alignment Length:	464	Identity:	133/464 - (28%)
Similarity:	200/464 - (43%)	Gaps:	104/464 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   127 FKCDVCSDMFPHLALLNAHKRMHTDGEQQQQQQHNAQAGGDSIAVVSAQGLVQAQNIIGNGQMGQ 191
            ||||:|...|...|.||.|..:|     .:::.......|.|..:.||   :.:..::..|:
Human   288 FKCDICCKSFRSRANLNRHSMVH-----MREKPFRCDTCGKSFGLKSA---LNSHRMVHTGE--- 341

  Fly   192 IQIVSSDTLEPVQQSVMQQQQHESKASKCINCGSSML-------QQSKRKGPKQVRCESCMQAEQ 249
                                    |..||..||...:       .|....|.|...|:.|.::.:
Human   342 ------------------------KRYKCEECGKRFIYRQDLYKHQIDHTGEKPYNCKECGKSFR 382

  Fly   250 TAQQQQQLFVAQDGQMAHPVQIISTTPQAQAQLQQIVAAQTGGTTPKREASSGSGHHPVKKRNSQ 314
            .|                            :.|.:.|...:|.||.|.| ..|.|.:...:|.|.
Human   383 WA----------------------------SGLSRHVRVHSGETTFKCE-ECGKGFYTNSQRYSH 418

  Fly   315 QMT-------KCQKCNGSGV---VLVGQHSHASHSGVGGSVKQSVTVKTEC------LSC----- 358
            |..       :|::| |.|.   :.:..|... |.|     ::....| ||      .||
Human   419 QRAHSGEKPYRCEEC-GKGYKRRLDLDFHQRV-HRG-----EKPYNCK-ECGKSFGWASCLLNHQ 475

  Fly   359 --RNPSKPFSCNICGGLFSRYSSLWSHKKLHSGEKNYKCSICGLAFAKAVYLKNHARIHTGEKPY 421
              .:..|||.|..||..|::.|.|::|:::|||||.:||..||..|.:...|.:|.|:|||.|||
Human   476 RIHSGEKPFKCEECGKRFTQNSQLYTHRRVHSGEKPFKCEECGKRFTQNSQLYSHRRVHTGVKPY 540

  Fly   422 KCQTCGMQFSQSPHLKNHERTHSGERPYVCGVCDKGFARHATLWNHRRIHTGEKPYKCEICGSAF 486
            ||:.||..|:...:|..|:|.|:|||||.|..|.|.|:|.:::.||:|:|..|||:|||.||..|
Human   541 KCEECGKGFNSKFNLDMHQRVHTGERPYNCKECGKSFSRASSILNHKRLHGDEKPFKCEECGKRF 605

  Fly   487 SQAAHLKNHAKVHSGEKPYKCEICSAAFADRFALKRHRGIHQKYGQTAPRQTSSDGMIVHKQEIP 551
            ::.:.|.:|.:||:||||||||.|..:|........|:.:|.:  :...:.......|||...:.
Human   606 TENSQLHSHQRVHTGEKPYKCEKCGKSFRWASTHLTHQRLHSR--EKLLQCEDCGKSIVHSSCLK 668

  Fly   552 DMEDEAQQE 560
            |.:.:...|
Human   669 DQQRDQSGE 677

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Clamp	NP_001014498.1	COG5048	<359..498	CDD:227381	63/138 (46%)
		C2H2 Zn finger	367..387	CDD:275368	7/19 (37%)
		zf-H2C2_2	379..403	CDD:290200	11/23 (48%)
		C2H2 Zn finger	395..415	CDD:275368	7/19 (37%)
		zf-H2C2_2	407..432	CDD:290200	14/24 (58%)
		C2H2 Zn finger	423..443	CDD:275368	7/19 (37%)
		zf-H2C2_2	435..460	CDD:290200	13/24 (54%)
		C2H2 Zn finger	451..471	CDD:275368	8/19 (42%)
		zf-H2C2_2	464..488	CDD:290200	13/23 (57%)
		COG5048	475..>529	CDD:227381	24/53 (45%)
		C2H2 Zn finger	479..499	CDD:275368	7/19 (37%)
		zf-H2C2_2	491..515	CDD:290200	13/23 (57%)
		C2H2 Zn finger	507..527	CDD:275368	5/19 (26%)
ZNF225	NP_001308614.1	KRAB	8..48	CDD:307490
		C2H2 Zn finger	153..170	CDD:275368
		C2H2 Zn finger	178..198	CDD:275368
		COG5048	202..634	CDD:227381	125/417 (30%)
		C2H2 Zn finger	206..226	CDD:275368
		C2H2 Zn finger	234..254	CDD:275368
		C2H2 Zn finger	262..282	CDD:275368
		C2H2 Zn finger	290..310	CDD:275368	8/19 (42%)
		C2H2 Zn finger	318..338	CDD:275368	4/22 (18%)
		C2H2 Zn finger	346..366	CDD:275368	4/19 (21%)
		C2H2 Zn finger	374..394	CDD:275368	5/47 (11%)
		C2H2 Zn finger	402..422	CDD:275368	6/20 (30%)
		C2H2 Zn finger	430..450	CDD:275368	5/21 (24%)
		C2H2 Zn finger	458..478	CDD:275368	5/20 (25%)
		C2H2 Zn finger	486..506	CDD:275368	7/19 (37%)
		C2H2 Zn finger	514..534	CDD:275368	7/19 (37%)
		C2H2 Zn finger	542..562	CDD:275368	7/19 (37%)
		C2H2 Zn finger	570..590	CDD:275368	8/19 (42%)
		C2H2 Zn finger	598..618	CDD:275368	7/19 (37%)
		C2H2 Zn finger	626..646	CDD:275368	5/19 (26%)
		C2H2 Zn finger	654..672	CDD:275368	4/17 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910