DRSC/TRiP Functional Genomics Resources

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Protein Alignment Clamp and ZKSCAN8

DIOPT Version :9

Sequence 1:NP_001014498.1 Gene:Clamp / 35445 FlyBaseID:FBgn0032979 Length:566 Species:Drosophila melanogaster
Sequence 2:NP_001265048.1 Gene:ZKSCAN8 / 7745 HGNCID:12983 Length:578 Species:Homo sapiens


Alignment Length:429 Identity:129/429 - (30%)
Similarity:190/429 - (44%) Gaps:133/429 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   130 DVCSDMFPHLALLNAHKRMHTDGEQQQQ--------------QQHN---AQAGGDSIAVVSAQGL 177
            |:|.|..|.    |........||.:.:              |.|.   |:..||.|     :||
Human   242 DLCRDNRPE----NFRNMFSLGGETRSENRELASKQVISTGIQPHGETAAKCNGDVI-----RGL 297

  Fly   178 --VQAQNIIGNGQMGQIQIVSSDTLEPVQQSVMQQQQHESKASKCINCGSSMLQQSK-------R 233
              .:|::::|.             ||..:.:..|:::|     ||..||.|..|.|.       .
Human   298 EHEEARDLLGR-------------LERQRGNPTQERRH-----KCDECGKSFAQSSGLVRHWRIH 344

  Fly   234 KGPKQVRCESCMQAEQTAQQQQQLFVAQDGQMAHPVQIISTTPQAQAQLQQIVAAQTGGTTPKRE 298
            .|.|..:|..|.:|          |..:...::|               |.|             
Human   345 TGEKPYQCNVCGKA----------FSYRSALLSH---------------QDI------------- 371

  Fly   299 ASSGSGHHPVKKRNSQQMTKCQKC-----NGSGVVLVGQHSHASHSGVGGSVKQSVTVKTECLSC 358
                  |:.||:.:      |::|     ..:|::|   |... |:|                  
Human   372 ------HNKVKRYH------CKECGKAFSQNTGLIL---HQRI-HTG------------------ 402

  Fly   359 RNPSKPFSCNICGGLFSRYSSLWSHKKLHSGEKNYKCSICGLAFAKAVYLKNHARIHTGEKPYKC 423
               .||:.||.||..||:.:.|..|:::||||:.|:|:.||.||:.:.:|..|.|||||||||:|
Human   403 ---EKPYQCNQCGKAFSQSAGLILHQRIHSGERPYECNECGKAFSHSSHLIGHQRIHTGEKPYEC 464

  Fly   424 QTCGMQFSQSPHLKNHERTHSGERPYVCGVCDKGFARHATLWNHRRIHTGEKPYKCEICGSAFSQ 488
            ..||..|.:|.||..|:|:|:||:||.|..|.:.|::.:.|..|:||||||:||||:.||.||:.
Human   465 DECGKTFRRSSHLIGHQRSHTGEKPYKCNECGRAFSQKSGLIEHQRIHTGERPYKCKECGKAFNG 529

  Fly   489 AAHLKNHAKVHSGEKPYKCEICSAAFADRFALKRHRGIH 527
            ...|..|.::|:|||||:|..|..||..|.:|.||:.||
Human   530 NTGLIQHLRIHTGEKPYQCNECGKAFIQRSSLIRHQRIH 568

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ClampNP_001014498.1 COG5048 <359..498 CDD:227381 66/138 (48%)
C2H2 Zn finger 367..387 CDD:275368 8/19 (42%)
zf-H2C2_2 379..403 CDD:290200 11/23 (48%)
C2H2 Zn finger 395..415 CDD:275368 8/19 (42%)
zf-H2C2_2 407..432 CDD:290200 15/24 (63%)
C2H2 Zn finger 423..443 CDD:275368 9/19 (47%)
zf-H2C2_2 435..460 CDD:290200 12/24 (50%)
C2H2 Zn finger 451..471 CDD:275368 6/19 (32%)
zf-H2C2_2 464..488 CDD:290200 16/23 (70%)
COG5048 475..>529 CDD:227381 26/53 (49%)
C2H2 Zn finger 479..499 CDD:275368 7/19 (37%)
zf-H2C2_2 491..515 CDD:290200 11/23 (48%)
C2H2 Zn finger 507..527 CDD:275368 8/19 (42%)
ZKSCAN8NP_001265048.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..20
SCAN 47..159 CDD:128708
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 158..205
KRAB_A-box 221..>262 CDD:322003 6/23 (26%)
COG5048 <315..564 CDD:227381 106/328 (32%)
C2H2 Zn finger 324..344 CDD:275368 6/19 (32%)
C2H2 Zn finger 380..400 CDD:275368 5/23 (22%)
C2H2 Zn finger 408..428 CDD:275368 8/19 (42%)
C2H2 Zn finger 436..456 CDD:275368 8/19 (42%)
C2H2 Zn finger 464..484 CDD:275368 9/19 (47%)
C2H2 Zn finger 492..512 CDD:275368 6/19 (32%)
C2H2 Zn finger 520..540 CDD:275368 7/19 (37%)
C2H2 Zn finger 548..568 CDD:275368 8/19 (42%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
00.000

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