DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Clamp and ZNF28

DIOPT Version :9

Sequence 1:	NP_001014498.1	Gene:	Clamp / 35445	FlyBaseID:	FBgn0032979	Length:	566	Species:	Drosophila melanogaster
Sequence 2:	NP_008900.3	Gene:	ZNF28 / 7576	HGNCID:	13073	Length:	718	Species:	Homo sapiens

Alignment Length:	468	Identity:	138/468 - (29%)
Similarity:	211/468 - (45%)	Gaps:	71/468 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   103 DAQGRIQIVNQNKPIAANTISNIS---FKCDVCSDMFPHLALLNAHKRMHTDGEQQQQQQHNAQA 164
            |..|:  :.||.:.:|.:..|:|.   :||:.|..:|.|...|..||.:||..:..:.::.:
Human   246 DVYGK--VFNQKRYLACHRRSHIDEKPYKCNECGKIFGHNTSLFLHKALHTADKPYECEECD--- 305

  Fly   165 GGDSIAVVSAQGLVQAQNIIGNGQMGQIQIVSSDTLEPVQQSVMQQ--------QQHE-----SK 216
                 .|.|.:..::...||..|.            :|.:..|..:        .:|.     .|
Human   306 -----KVFSRKSHLETHKIIYTGG------------KPYKCKVCDKAFTCNSYLAKHTIIHTGEK 353

  Fly   217 ASKCINCGS-----SMLQQSKR--KGPKQVRCESCMQAEQTAQQQQQLFVAQDGQMAHPVQIIST 274
            ..||..||.     |.|.:.:|  .|.|...||.|.:........::......|:..:..::...
Human   354 PYKCNECGKVFNRLSTLARHRRLHTGEKPYECEECEKVFSRKSHLERHKRIHTGEKPYKCKVCDK 418

  Fly   275 TPQAQAQLQQIVAAQTGGTTPK--------REASSGSGHHPVKKRNSQQMTKCQKCNGSGVVLVG 331
            .....:.|.:.....||....|        .:.|:.:.||  :...:::..||::|:    .:..
Human   419 AFAYNSYLAKHSIIHTGEKPYKCNECGKVFNQQSTLARHH--RLHTAEKPYKCEECD----KVFR 477

  Fly   332 QHSHAS-----HSG-------VGGSVKQSVTVKTECLSCRNPSKPFSCNICGGLFSRYSSLWSHK 384
            ..||..     |:|       |.....:|.:..||........||:.||.||.:||..::|..|.
Human   478 CKSHLERHRRIHTGEKPYKCKVCDKAFRSDSCLTEHQRVHTGEKPYMCNECGKVFSTKANLACHH 542

  Fly   385 KLHSGEKNYKCSICGLAFAKAVYLKNHARIHTGEKPYKCQTCGMQFSQSPHLKNHERTHSGERPY 449
            |||:.||.|||..|...|::..:::.|.|||||||||||:.|...|.:..||..|:|.|:||:||
Human   543 KLHTAEKPYKCEECEKVFSRKSHMERHRRIHTGEKPYKCKVCDKAFRRDSHLAQHQRVHTGEKPY 607

  Fly   450 VCGVCDKGFARHATLWNHRRIHTGEKPYKCEICGSAFSQAAHLKNHAKVHSGEKPYKCEICSAAF 514
            .|..|.|.|.:.::|..|||:|||||||||..||..|||.:.|..|.::|||||||||..|...|
Human   608 KCNECGKTFRQTSSLIIHRRLHTGEKPYKCNECGKTFSQMSSLVYHHRLHSGEKPYKCNECGKVF 672

  Fly   515 ADRFALKRHRGIH 527
            ..:..|.:|:.:|
Human   673 NQQAHLAQHQRVH 685

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Clamp	NP_001014498.1	COG5048	<359..498	CDD:227381	67/138 (49%)
		C2H2 Zn finger	367..387	CDD:275368	9/19 (47%)
		zf-H2C2_2	379..403	CDD:290200	11/23 (48%)
		C2H2 Zn finger	395..415	CDD:275368	5/19 (26%)
		zf-H2C2_2	407..432	CDD:290200	14/24 (58%)
		C2H2 Zn finger	423..443	CDD:275368	7/19 (37%)
		zf-H2C2_2	435..460	CDD:290200	13/24 (54%)
		C2H2 Zn finger	451..471	CDD:275368	8/19 (42%)
		zf-H2C2_2	464..488	CDD:290200	16/23 (70%)
		COG5048	475..>529	CDD:227381	26/53 (49%)
		C2H2 Zn finger	479..499	CDD:275368	8/19 (42%)
		zf-H2C2_2	491..515	CDD:290200	12/23 (52%)
		C2H2 Zn finger	507..527	CDD:275368	5/19 (26%)
ZNF28	NP_008900.3	KRAB	8..>48	CDD:214630
		KRAB	8..47	CDD:279668
		COG5048	<143..373	CDD:227381	32/148 (22%)
		C2H2 Zn finger	217..237	CDD:275368
		C2H2 Zn finger	245..265	CDD:275368	5/20 (25%)
		COG5048	267..655	CDD:227381	117/413 (28%)
		C2H2 Zn finger	273..293	CDD:275368	7/19 (37%)
		C2H2 Zn finger	301..321	CDD:275368	3/27 (11%)
		C2H2 Zn finger	329..349	CDD:275368	2/19 (11%)
		zf-H2C2_2	341..366	CDD:290200	6/24 (25%)
		C2H2 Zn finger	357..377	CDD:275368	6/19 (32%)
		zf-H2C2_2	370..394	CDD:290200	7/23 (30%)
		C2H2 Zn finger	385..405	CDD:275368	3/19 (16%)
		zf-H2C2_2	397..422	CDD:290200	1/24 (4%)
		C2H2 Zn finger	413..433	CDD:275368	1/19 (5%)
		zf-H2C2_2	425..450	CDD:290200	4/24 (17%)
		C2H2 Zn finger	441..461	CDD:275368	3/21 (14%)
		C2H2 Zn finger	469..489	CDD:275368	4/23 (17%)
		zf-H2C2_2	481..506	CDD:290200	4/24 (17%)
		C2H2 Zn finger	497..517	CDD:275368	4/19 (21%)
		zf-H2C2_2	510..534	CDD:290200	9/23 (39%)
		C2H2 Zn finger	525..545	CDD:275368	9/19 (47%)
		C2H2 Zn finger	553..573	CDD:275368	5/19 (26%)
		zf-H2C2_2	565..590	CDD:290200	14/24 (58%)
		C2H2 Zn finger	581..601	CDD:275368	7/19 (37%)
		zf-H2C2_2	593..618	CDD:290200	13/24 (54%)
		C2H2 Zn finger	609..629	CDD:275368	8/19 (42%)
		zf-H2C2_2	621..646	CDD:290200	16/24 (67%)
		C2H2 Zn finger	637..657	CDD:275368	8/19 (42%)
		C2H2 Zn finger	665..685	CDD:275368	5/19 (26%)
		zf-H2C2_2	677..702	CDD:290200	3/9 (33%)
		C2H2 Zn finger	693..713	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910