DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Clamp and ZNF3

DIOPT Version :9

Sequence 1:NP_001014498.1 Gene:Clamp / 35445 FlyBaseID:FBgn0032979 Length:566 Species:Drosophila melanogaster
Sequence 2:NP_001305065.1 Gene:ZNF3 / 7551 HGNCID:13089 Length:453 Species:Homo sapiens


Alignment Length:214 Identity:94/214 - (43%)
Similarity:126/214 - (58%) Gaps:28/214 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly   318 KCQKC----NGSGVVLVGQHSHASHSGVGGSVKQSVTVKTECLSCRNPSKPFSCNICGGLFSRYS 378
            ||.:|    |.:..::  ||... |:|                     .||:.||.||..||:.|
Human   208 KCDECSKSFNRTSDLI--QHQRI-HTG---------------------EKPYECNECGKAFSQSS 248

  Fly   379 SLWSHKKLHSGEKNYKCSICGLAFAKAVYLKNHARIHTGEKPYKCQTCGMQFSQSPHLKNHERTH 443
            .|..|:::|:|||.|:||.||..|:.:..|..|.|||||||||:|..||..||.|..|.:|:|.|
Human   249 HLIQHQRIHTGEKPYECSDCGKTFSCSSALILHRRIHTGEKPYECNECGKTFSWSSTLTHHQRIH 313

  Fly   444 SGERPYVCGVCDKGFARHATLWNHRRIHTGEKPYKCEICGSAFSQAAHLKNHAKVHSGEKPYKCE 508
            :||:||.|..|.|.|:|.:||.:|:|||||||||:|..||.||||::||..|.::|:|||||:|.
Human   314 TGEKPYACNECGKAFSRSSTLIHHQRIHTGEKPYECNECGKAFSQSSHLYQHQRIHTGEKPYECM 378

  Fly   509 ICSAAFADRFALKRHRGIH 527
            .|...|.....|.:|:.||
Human   379 ECGGKFTYSSGLIQHQRIH 397

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ClampNP_001014498.1 COG5048 <359..498 CDD:227381 73/138 (53%)
C2H2 Zn finger 367..387 CDD:275368 9/19 (47%)
zf-H2C2_2 379..403 CDD:290200 11/23 (48%)
C2H2 Zn finger 395..415 CDD:275368 8/19 (42%)
zf-H2C2_2 407..432 CDD:290200 15/24 (63%)
C2H2 Zn finger 423..443 CDD:275368 9/19 (47%)
zf-H2C2_2 435..460 CDD:290200 12/24 (50%)
C2H2 Zn finger 451..471 CDD:275368 9/19 (47%)
zf-H2C2_2 464..488 CDD:290200 16/23 (70%)
COG5048 475..>529 CDD:227381 26/53 (49%)
C2H2 Zn finger 479..499 CDD:275368 10/19 (53%)
zf-H2C2_2 491..515 CDD:290200 11/23 (48%)
C2H2 Zn finger 507..527 CDD:275368 5/19 (26%)
ZNF3NP_001305065.1 KRAB 57..98 CDD:366587
COG5048 <182..360 CDD:227381 78/175 (45%)
C2H2 Zn finger 185..201 CDD:275368
C2H2 Zn finger 209..229 CDD:275368 5/22 (23%)
C2H2 Zn finger 237..257 CDD:275368 9/19 (47%)
C2H2 Zn finger 265..285 CDD:275368 8/19 (42%)
C2H2 Zn finger 293..313 CDD:275368 9/19 (47%)
C2H2 Zn finger 321..341 CDD:275368 9/19 (47%)
C2H2 Zn finger 349..369 CDD:275368 10/19 (53%)
zf-H2C2_2 361..386 CDD:372612 12/24 (50%)
C2H2 Zn finger 377..397 CDD:275368 5/19 (26%)
zf-H2C2_2 390..414 CDD:372612 4/8 (50%)
C2H2 Zn finger 405..425 CDD:275368
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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