DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Clamp and Zbtb49

DIOPT Version :9

Sequence 1:	NP_001014498.1	Gene:	Clamp / 35445	FlyBaseID:	FBgn0032979	Length:	566	Species:	Drosophila melanogaster
Sequence 2:	NP_083438.1	Gene:	Zbtb49 / 75079	MGIID:	1922329	Length:	756	Species:	Mus musculus

Alignment Length:	540	Identity:	136/540 - (25%)
Similarity:	215/540 - (39%)	Gaps:	108/540 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    84 ALVNGMPLNQGAALGIATVDA---------------------QGRIQI-VNQNKPIAANTISNIS 126
            |.:.|:|...|.:|....:|.                     |.::.. ||...|.|..:.....
Mouse   123 AQLPGLPCAGGFSLQSVALDGTCAVSEHYPPPSLQECPVEGPQAKVPAEVNARAPSANFSRPTEV 187

  Fly   127 FKCDVCSDMFPHLALL--NAHKRMHTDGEQQQQQQHNAQAGGDSIAVVSAQGLVQAQNIIGNGQM 189
            .|.|......|.|...  |.:.::.|    ...:|:..|....|....:.|.|.::
Mouse   188 SKPDAAGGSCPELPCKQPNHYYKLRT----LYSKQYYKQTACPSQVPATQQPLTRS--------- 239

  Fly   190 GQIQIVSSDTLEPVQ--QSVMQQQQHESK---ASKCINCGSSMLQQSKRKGP-KQVRCESCMQAE 248
            ....:.::|:..||:  .:|::..:|...   |....|.|:........:.| ||:|.:..|..:
Mouse   240 ASTDLAAADSQPPVEGRPAVLETPEHLPSTFVAPPVRNSGNDSEADPLSEPPAKQMRLKKAMHLK 304

  Fly   249 Q----TAQQQQQLFVAQDGQMAHPVQIISTTPQAQAQLQQIVAAQTGGTTPKRE----------- 298
            :    .:||..:.       .:||........:.::..::....:.|..|.:.:
Mouse   305 KLNFLKSQQSAEC-------TSHPEPDNGLARREESAAKEDAVERAGSQTAEEKGRGELGPESSR 362

  Fly   299 -----ASSGSGHHPVKKRNSQQMTKCQKC-----NGSGVVLVGQHSHASHSGVGGSVKQSVTVKT 353
                 .:..|...|.:....|:...|:.|     :.|.:.|   |.. ||:|
Mouse   363 EEELPGAPASWEDPSQALQPQKQYACELCGKPFKHPSNLEL---HKR-SHTG------------- 410

  Fly   354 ECLSCRNPSKPFSCNICGGLFSRYSSLWSHKKLHSGEKNYKCSICGLAFAKAVYLKNHARIHTGE 418
                    .|||.|||||..||:..:|.:|.:.|||||.|.|.|||..||.:..::.|..||:||
Mouse   411 --------EKPFECNICGKHFSQAGNLQTHLRRHSGEKPYICEICGKRFAASGDVQRHIIIHSGE 467

  Fly   419 KPYKCQTCGMQFSQSPHLKNHERTHSGERPYVCGVCDKGFARHATLWNHRRIHTGEKPYKCEICG 483
            ||:.|.|||..||...:||.|::||:.::.:.|..|.|.|.....|..||..||||:||.|..||
Mouse   468 KPHLCDTCGRGFSNFSNLKEHKKTHTADKVFTCDECGKSFNMQRKLVKHRVRHTGERPYSCPACG 532

  Fly   484 SAFSQAAHLKNHAKVHSGEKPYKCEICSAAFADRFALKRHRGIHQKYGQTAPRQTSSDGMIVHKQ 548
            ..|..:..|:.|.:.|:|||||.||:||..|.....|:||:.:|   |:...|.....|.:....
Mouse   533 KCFGGSGDLRRHVRTHTGEKPYSCEVCSKCFTRSAVLRRHKRMH---GRADARSPVVLGELSRPI 594

  Fly   549 EIPDME-----DEAQQEVII 563
            |..|::     |...|:|.:
Mouse   595 EPSDLDRSQSSDSFSQDVSV 614

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Clamp	NP_001014498.1	COG5048	<359..498	CDD:227381	61/138 (44%)
		C2H2 Zn finger	367..387	CDD:275368	9/19 (47%)
		zf-H2C2_2	379..403	CDD:290200	12/23 (52%)
		C2H2 Zn finger	395..415	CDD:275368	7/19 (37%)
		zf-H2C2_2	407..432	CDD:290200	12/24 (50%)
		C2H2 Zn finger	423..443	CDD:275368	9/19 (47%)
		zf-H2C2_2	435..460	CDD:290200	9/24 (38%)
		C2H2 Zn finger	451..471	CDD:275368	7/19 (37%)
		zf-H2C2_2	464..488	CDD:290200	13/23 (57%)
		COG5048	475..>529	CDD:227381	23/53 (43%)
		C2H2 Zn finger	479..499	CDD:275368	6/19 (32%)
		zf-H2C2_2	491..515	CDD:290200	12/23 (52%)
		C2H2 Zn finger	507..527	CDD:275368	8/19 (42%)
Zbtb49	NP_083438.1	BTB	15..118	CDD:279045
		BTB	26..119	CDD:197585
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	176..197		4/20 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	226..290		11/72 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	311..379		8/74 (11%)
		COG5048	<376..576	CDD:227381	85/224 (38%)
		zf-C2H2	386..408	CDD:278523	5/25 (20%)
		C2H2 Zn finger	388..408	CDD:275368	5/23 (22%)
		zf-H2C2_2	400..425	CDD:290200	14/49 (29%)
		C2H2 Zn finger	416..436	CDD:275368	9/19 (47%)
		zf-H2C2_2	428..452	CDD:290200	12/23 (52%)
		C2H2 Zn finger	444..464	CDD:275368	7/19 (37%)
		zf-H2C2_2	456..481	CDD:290200	12/24 (50%)
		C2H2 Zn finger	472..492	CDD:275368	9/19 (47%)
		zf-H2C2_2	484..508	CDD:290200	8/23 (35%)
		C2H2 Zn finger	500..520	CDD:275368	7/19 (37%)
		zf-H2C2_2	513..535	CDD:290200	12/21 (57%)
		C2H2 Zn finger	528..548	CDD:275368	6/19 (32%)
		zf-H2C2_2	540..565	CDD:290200	13/24 (54%)
		C2H2 Zn finger	556..576	CDD:275368	8/19 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000