Protein Alignment Clamp and Zfp626

DIOPT Version :10

• Sequence 1: NP_001014498.1
• Gene: Clamp / 35445
• FlyBaseID: FBgn0032979
• Length: 566
• Species: Drosophila melanogaster
• Sequence 2: NP_081979.1
• Gene: Zfp626 / 71163
• MGIID: 1918413
• Length: 676
• Species: Mus musculus
• Alignment Length: 543
• Identity: 129/543 - (23%)
• Similarity: 198/543 - (36%)
• Gaps: 189/543 - (34%)

  Fly   116 PIAANTISNI---SFKCDVCSDMFPHLALLNAHKRMHTDGEQQQQQQHNAQAGGDSIAVVSAQGL 177
            |....|:::.   .::|..|...|...:.|:.|:.:|...:..:.:::
Mouse   159 PYTCQTLAHSLQKPYECKQCGKCFNCSSTLSQHQSVHAGEKPYECKEY----------------- 206

  Fly   178 VQAQNIIGNGQMGQIQIVSSDTLEPVQQSVMQQQQHES-KASKCINCGSS-----MLQQSK--RK 234
                     |::.::.          ||....|:.|.| |..:|..||.:     :||..|  ..
Mouse   207 ---------GKVFRLP----------QQLTRHQKSHSSEKPFECNECGKAFHLPHLLQNHKTTHT 252

  Fly   235 GPKQVRCESCMQAEQTAQQQQQLFVAQDGQMAHPVQIISTTPQAQAQLQQIVAAQTGGTTPKREA 299
            |.|...||.|          .::|......:||.:        ..|.::.....:.|....:|
Mouse   253 GTKAFECEEC----------GKIFNRVSNLVAHRI--------IHADVKPYKCNECGKAFKRR-- 297

  Fly   300 SSGSGHHPVKKRNSQQMTKCQKC----------NGSGVVLVGQHSHAS----------------- 337
            |....|.  |..:.::..:|::|          ||..::..|:.|.|.
Mouse   298 SYYMQHQ--KIHSGERPFQCKECGKAFIFLAHLNGHQMIHTGEKSFACKECGKAFRLLQQLTRHQ 360

  Fly   338 --HSG--------------VGGSVKQSVTVKT-----ECLSC----------------RNPSKPF 365
              |||              ....:|...|:.|     ||..|                ....||:
Mouse   361 KFHSGDRPFKCNECGKAFPFPDRLKLHKTIHTNTKPFECRECGKSFKCVSHLAQHRIIHADVKPY 425

  Fly   366 SCNICGGLFSRYSSLWSHKKLHSGEKNYKCSICGLAFAKAVYLKNHARIHTGEKPYKCQTCGMQF 430
            .|:.||..|:|.|:|..|:|:|||||.::|..||.||.....|..|.||||||||::|:.||.:|
Mouse   426 ECSECGKAFNRRSNLIQHQKIHSGEKPFECKDCGKAFTVLPQLTRHQRIHTGEKPFECKECGKKF 490

  Fly   431 SQSPHLKNHERTHSGERPYVCGVCDKGFARHATLWNHRRIHTGEKPYKCEICGSAFSQ------- 488
            ...|||..|:|.|:||:|:.|.||.|.|...|.|..|::.|..|||:||::|||||..
Mouse   491 YTGPHLAQHQRVHTGEKPFECNVCGKAFRLRACLSEHQKTHIEEKPFKCKLCGSAFRSRYQLSLH 555

  Fly   489 -------------------------------------------------AAHLKNHAKVHSGEKP 504
                                                             .:||..|...|:||||
Mouse   556 RQTHPHVRPFQCQECGKAYILLAQLIQHQTVHTGERSFECKECGKKFHTGSHLVQHQHFHTGEKP 620

  Fly   505 YKCEICSAAFADRFALKRHRGIH 527
            ::|.:|..||..:..|..|:..|
Mouse   621 FECHVCGKAFRFQVYLSEHQKTH 643

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Clamp	NP_001014498.1	COG5048	<359..498	CDD:227381	66/194 (34%)
		C2H2 Zn finger	367..387	CDD:275368	9/19 (47%)
		C2H2 Zn finger	395..415	CDD:275368	8/19 (42%)
		zf-H2C2_2	407..432	CDD:463886	14/24 (58%)
		C2H2 Zn finger	423..443	CDD:275368	9/19 (47%)
		C2H2 Zn finger	451..471	CDD:275368	8/19 (42%)
		COG5048	475..>529	CDD:227381	24/109 (22%)
		C2H2 Zn finger	479..499	CDD:275368	9/75 (12%)
		C2H2 Zn finger	507..527	CDD:275368	6/19 (32%)
Zfp626	NP_081979.1	KRAB	14..75	CDD:214630
		COG5048	170..572	CDD:227381	112/459 (24%)
		C2H2 Zn finger	175..195	CDD:275368	5/19 (26%)
		C2H2 Zn finger	203..223	CDD:275368	4/55 (7%)
		C2H2 Zn finger	231..251	CDD:275368	6/19 (32%)
		C2H2 Zn finger	259..279	CDD:275368	6/37 (16%)
		C2H2 Zn finger	287..307	CDD:275368	5/23 (22%)
		C2H2 Zn finger	315..335	CDD:275368	4/19 (21%)
		C2H2 Zn finger	343..363	CDD:275368	0/19 (0%)
		C2H2 Zn finger	371..391	CDD:275368	2/19 (11%)
		C2H2 Zn finger	399..419	CDD:275368	2/19 (11%)
		C2H2 Zn finger	427..447	CDD:275368	9/19 (47%)
		C2H2 Zn finger	455..475	CDD:275368	8/19 (42%)
		C2H2 Zn finger	483..503	CDD:275368	9/19 (47%)
		C2H2 Zn finger	511..531	CDD:275368	8/19 (42%)
		C2H2 Zn finger	539..559	CDD:275368	6/19 (32%)
		SUF4-like	563..>611	CDD:411020	2/47 (4%)
		C2H2 Zn finger	567..588	CDD:411020	0/20 (0%)
		C2H2 Zn finger	567..587	CDD:275368	0/19 (0%)
		C2H2 Zn finger	595..615	CDD:275368	3/19 (16%)
		zf-H2C2_2	607..630	CDD:463886	10/22 (45%)
		C2H2 Zn finger	623..643	CDD:275368	6/19 (32%)
		C2H2 Zn finger	651..671	CDD:275368