DRSC/TRiP Functional Genomics Resources

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Protein Alignment Clamp and IKZF4

DIOPT Version :9

Sequence 1:NP_001014498.1 Gene:Clamp / 35445 FlyBaseID:FBgn0032979 Length:566 Species:Drosophila melanogaster
Sequence 2:NP_001338018.1 Gene:IKZF4 / 64375 HGNCID:13179 Length:585 Species:Homo sapiens


Alignment Length:335 Identity:85/335 - (25%)
Similarity:119/335 - (35%) Gaps:104/335 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   276 PQAQAQ----LQQIVAAQTGGTTPKREASSGSGHHPVKKRNSQQMTKCQKCNGSGVVLVGQHSHA 336
            ||||..    ::.:....:|.::.::|.........|...||                  |||..
Human    44 PQAQDSNHFIMESLFCESSGDSSLEKEFLGAPVGPSVSTPNS------------------QHSSP 90

  Fly   337 SHSGVGGSVKQSVTVKTECLSCRNP-----------------SKPFSCNICGGLFSRYSSLWSHK 384
            |.|....|:|..:....|......|                 |:|.  ..|.|     |....|.
Human    91 SRSLSANSIKVEMYSDEESSRLLGPDERLLEKDDSVIVEDSLSEPL--GYCDG-----SGPEPHS 148

  Fly   385 ----KLHSGEKNYKCSICGLAFAKAVYLKNHARIHTGEKPYKCQTCGMQFSQSPHLKNHERTHSG 445
                :|.:|:  .||.:||:.......|..|.|.||||:|:.|..||..|:|..:|..|.:.|||
Human   149 PGGIRLPNGK--LKCDVCGMVCIGPNVLMVHKRSHTGERPFHCNQCGASFTQKGNLLRHIKLHSG 211

  Fly   446 ERPYVCGVCDKGFARHATLWNHRRIH-----TGEKPYKCEICGSAFSQAAHLKNH---------- 495
            |:|:.|..|:....|...|..|.|.|     |..|||||..||.::.|.:.|:.|          
Human   212 EKPFKCPFCNYACRRRDALTGHLRTHSVSSPTVGKPYKCNYCGRSYKQQSTLEEHKERCHNYLQS 276

  Fly   496 ------------------------AKVH-SGEKPYKCEICSAAFADRFA---LKRHRGIHQKY-G 531
                                    :.:| |.|:|        .|.||.|   .||.|...||: |
Human   277 LSTEAQALAGQPGDEIRDLEMVPDSMLHSSSERP--------TFIDRLANSLTKRKRSTPQKFVG 333

  Fly   532 QTAPRQTSSD 541
            :...|.:.||
Human   334 EKQMRFSLSD 343

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ClampNP_001014498.1 COG5048 <359..498 CDD:227381 51/198 (26%)
C2H2 Zn finger 367..387 CDD:275368 4/23 (17%)
zf-H2C2_2 379..403 CDD:290200 7/27 (26%)
C2H2 Zn finger 395..415 CDD:275368 6/19 (32%)
zf-H2C2_2 407..432 CDD:290200 12/24 (50%)
C2H2 Zn finger 423..443 CDD:275368 7/19 (37%)
zf-H2C2_2 435..460 CDD:290200 9/24 (38%)
C2H2 Zn finger 451..471 CDD:275368 6/19 (32%)
zf-H2C2_2 464..488 CDD:290200 12/28 (43%)
COG5048 475..>529 CDD:227381 21/91 (23%)
C2H2 Zn finger 479..499 CDD:275368 6/53 (11%)
zf-H2C2_2 491..515 CDD:290200 6/58 (10%)
C2H2 Zn finger 507..527 CDD:275368 7/22 (32%)
IKZF4NP_001338018.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..43
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 68..98 9/47 (19%)
C2H2 Zn finger 161..181 CDD:275368 6/19 (32%)
zf-H2C2_2 174..198 CDD:404364 12/23 (52%)
C2H2 Zn finger 189..209 CDD:275368 7/19 (37%)
zf-H2C2_2 201..226 CDD:404364 9/24 (38%)
SFP1 <211..271 CDD:227516 21/59 (36%)
C2H2 Zn finger 217..237 CDD:275368 6/19 (32%)
C2H2 Zn finger 250..271 CDD:275368 6/20 (30%)
Interaction with FOXP3. /evidence=ECO:0000250|UniProtKB:Q8C208 281..585 17/71 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 410..489
CTBP-binding motif PEDLA 425..429
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
00.000

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