DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Clamp and BCL6

DIOPT Version :9

Sequence 1:	NP_001014498.1	Gene:	Clamp / 35445	FlyBaseID:	FBgn0032979	Length:	566	Species:	Drosophila melanogaster
Sequence 2:	NP_001124317.1	Gene:	BCL6 / 604	HGNCID:	1001	Length:	706	Species:	Homo sapiens

Alignment Length:	470	Identity:	134/470 - (28%)
Similarity:	190/470 - (40%)	Gaps:	122/470 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   115 KPIAANTISNISFKCDVCSDMFPHLALLNAHKRMHTDGEQQQQQQHNAQAGGDSIAV-------- 171
            ||.|.:..:...|.||..|                     :::::.:::   |.||:
Human   282 KPAAPSARNAPYFPCDKAS---------------------KEEERPSSE---DEIALHFEPPNAP 322

  Fly   172 VSAQGLVQAQNIIGNGQMGQIQIVSSDTLEPVQQSVMQQQQHESKASK--CI------------- 221
            ::.:|||..|:                   |.:.........||.:||  ||
Human   323 LNRKGLVSPQS-------------------PQKSDCQPNSPTESCSSKNACILQASGSPPAKSPT 368

  Fly   222 ---NCG---------SSMLQQSKRKGPKQVR--------------CESCMQAEQTAQQQQQLFVA 260
               .|.         :|:.|.:|.:||:|..              |:..|:.|....|......|
Human   369 DPKACNWKKYKFIVLNSLNQNAKPEGPEQAELGRLSPRAYTAPPACQPPMEPENLDLQSPTKLSA 433

  Fly   261 QDGQMAHPVQIISTTPQAQAQLQQIV-AAQTGGTTPKREASSGSGHHPVKKRNSQQMTKCQKCNG 324
            ....        ||.||| ::|..|| .:.||......|:.|....||         .||..|..
Human   434 SGED--------STIPQA-SRLNNIVNRSMTGSPRSSSESHSPLYMHP---------PKCTSCGS 480

  Fly   325 SGVVLVGQHSHASHSGVGGSVKQSV-TVKTEC--LSCRNPSKPFSCNICGGLFSRYSSLWSHKKL 386
            ..    .||:.......|.:..:.: ..::|.  .||.|.:  |.||.|...||..:||..|...
Human   481 QS----PQHAEMCLHTAGPTFPEEMGETQSEYSDSSCENGA--FFCNECDCRFSEEASLKRHTLQ 539

  Fly   387 HSGEKNYKCSICGLAFAKAVYLKNHARIHTGEKPYKCQTCGMQFSQSPHLKNHERTHSGERPYVC 451
            ...:|.|||..|..:|.....|.:|..:|||||||:|..||.||::..:||.|.|.||||:||.|
Human   540 THSDKPYKCDRCQASFRYKGNLASHKTVHTGEKPYRCNICGAQFNRPANLKTHTRIHSGEKPYKC 604

  Fly   452 GVCDKGFARHATLWNHRRIHTGEKPYKCEICGSAFSQAAHLKNHAKVHSGEKPYKCEICSAAFAD 516
            ..|...|.:.|.|..|..||||||||.|||||:.|.....||:|.::|:|||||.||.|:..|..
Human   605 ETCGARFVQVAHLRAHVLIHTGEKPYPCEICGTRFRHLQTLKSHLRIHTGEKPYHCEKCNLHFRH 669

  Fly   517 RFALKRHRGIHQKYG 531
            :..|:.|  :.||:|
Human   670 KSQLRLH--LRQKHG 682

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Clamp	NP_001014498.1	COG5048	<359..498	CDD:227381	63/138 (46%)
		C2H2 Zn finger	367..387	CDD:275368	8/19 (42%)
		zf-H2C2_2	379..403	CDD:290200	8/23 (35%)
		C2H2 Zn finger	395..415	CDD:275368	5/19 (26%)
		zf-H2C2_2	407..432	CDD:290200	14/24 (58%)
		C2H2 Zn finger	423..443	CDD:275368	9/19 (47%)
		zf-H2C2_2	435..460	CDD:290200	13/24 (54%)
		C2H2 Zn finger	451..471	CDD:275368	6/19 (32%)
		zf-H2C2_2	464..488	CDD:290200	16/23 (70%)
		COG5048	475..>529	CDD:227381	24/53 (45%)
		C2H2 Zn finger	479..499	CDD:275368	9/19 (47%)
		zf-H2C2_2	491..515	CDD:290200	12/23 (52%)
		C2H2 Zn finger	507..527	CDD:275368	6/19 (32%)
BCL6	NP_001124317.1	BTB	22..126	CDD:279045
		BTB	33..126	CDD:197585
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	317..349		7/50 (14%)
		Required for interaction with NuRD complex and for transcriptional repressor activity	376..379		0/2 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	407..467		16/68 (24%)
		C2H2 Zn finger	520..541	CDD:275368	8/20 (40%)
		C2H2 Zn finger	548..568	CDD:275368	5/19 (26%)
		zf-H2C2_2	560..585	CDD:290200	14/24 (58%)
		C2H2 Zn finger	576..596	CDD:275368	9/19 (47%)
		zf-H2C2_2	588..613	CDD:290200	13/24 (54%)
		C2H2 Zn finger	604..624	CDD:275368	6/19 (32%)
		zf-H2C2_2	616..641	CDD:290200	16/24 (67%)
		C2H2 Zn finger	632..652	CDD:275368	9/19 (47%)
		zf-H2C2_2	645..669	CDD:290200	13/23 (57%)
		C2H2 Zn finger	660..678	CDD:275368	6/19 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910