DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Clamp and Zfp112

DIOPT Version :9

Sequence 1:	NP_001014498.1	Gene:	Clamp / 35445	FlyBaseID:	FBgn0032979	Length:	566	Species:	Drosophila melanogaster
Sequence 2:	XP_036009176.1	Gene:	Zfp112 / 57745	MGIID:	1929115	Length:	883	Species:	Mus musculus

Alignment Length:	569	Identity:	158/569 - (27%)
Similarity:	233/569 - (40%)	Gaps:	151/569 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 NAINGQPA-TIQYQTADGT--ILKQPKIEGQKTEQQPTFYYTTNGN---GGTVNLAQLA-TTDDN 69
            :|::|.|. ....:.|||:  :...|::   ..||.|.   ..:||   |..:|....| ..:.:
Mouse   307 SALHGHPGLEAGDEGADGSPPLQSSPRV---CMEQVPR---ECSGNVHYGSPLNTCGCAHPGNTS 365

  Fly    70 KTCYI-AQPVGG----------------YNYALVNGMPLNQGAALGIA-TVDAQGRI-QIVNQNK 115
            :||.| .|.||.                .||. .|....||.:.|.:: .:.|:.:: |.|...|
Mouse   366 QTCSIPKQAVGSPVHCNSTFRAHPREEPNNYE-ENRNVFNQSSCLQVSRKIGAEEKLCQGVECRK 429

  Fly   116 PIAANTISNISFKCDV--------CSDMF---PHLALLNAHKRMHTDGEQQQQQQHN--AQAGGD 167
            .....:..||..:..|        |.:.|   ||.        ....|.:.::|.||  .:.|..
Mouse   430 NFTHCSSLNIPHRVPVEETLCNPDCGNHFSLPPHF--------QDFPGVRAREQPHNRLCRTGFS 486

  Fly   168 SIAVVSAQGLVQAQNIIGNGQMGQIQIVSSDTLEPVQQSVMQQQQHESKASKCINCGSSMLQQSK 232
            ....:.....:..:....:.:.|.....||...:|.:|          |..||..||.....:|.
Mouse   487 QTLCLQGHQKLHIREKPSHREGGSGCNWSSTPKDPQKQ----------KLHKCNACGKGFSHRSV 541

  Fly   233 -------RKGPKQVRCESCMQAEQTAQQQQQLFVAQDGQMAHPVQIISTTPQAQAQLQQIVAAQT 290
                   ..|.|..:||.|.:....:                            |.||
Mouse   542 LDIHHRIHTGEKPYKCEECGKGFSRS----------------------------AYLQ------- 571

  Fly   291 GGTTPKREASSGSGHHPVKKRNSQQMTKCQKCNGSGVVLVGQHSHAS-----HSGVGGSVKQSVT 350
                         ||..|  ...::..||::| |.|   ..:.||..     |:|
Mouse   572 -------------GHQRV--HTGEKPYKCEEC-GKG---FSRSSHLQGHQRVHTG---------- 607

  Fly   351 VKTECLSCRNPSKPFSCNICGGLFSRYSSLWSHKKLHSGEKNYKCSICGLAFAKAVYLKNHARIH 415
                       .||:.|..||..||...:|..|:::|:|||.|||..||..|:||..|..|.|:|
Mouse   608 -----------EKPYKCEECGKGFSWSFNLQIHQRVHTGEKPYKCGECGKGFSKASTLLAHERVH 661

  Fly   416 TGEKPYKCQTCGMQFSQSPHLKNHERTHSGERPYVCGVCDKGFARHATLWNHRRIHTGEKPYKCE 480
            ||||||:|..||..|||..:|::|:..||||||::|.||.|||::.|.|..|.|:||..||||||
Mouse   662 TGEKPYQCHECGKNFSQKSYLQSHQSVHSGERPHICEVCGKGFSQRAYLQGHLRVHTRVKPYKCE 726

  Fly   481 ICGSAFSQAAHLKNHAKVHSGEKPYKCEICSAAFADRFALKRHRGIHQK 529
            :||..|||.:.|:.|.:||:|.||:|||.|:..|::...|:.|:.||::
Mouse   727 VCGKGFSQGSRLEAHQRVHTGRKPFKCETCTKGFSESSRLQAHQRIHEE 775

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Clamp	NP_001014498.1	COG5048	<359..498	CDD:227381	70/138 (51%)
		C2H2 Zn finger	367..387	CDD:275368	7/19 (37%)
		zf-H2C2_2	379..403	CDD:290200	11/23 (48%)
		C2H2 Zn finger	395..415	CDD:275368	9/19 (47%)
		zf-H2C2_2	407..432	CDD:290200	14/24 (58%)
		C2H2 Zn finger	423..443	CDD:275368	8/19 (42%)
		zf-H2C2_2	435..460	CDD:290200	14/24 (58%)
		C2H2 Zn finger	451..471	CDD:275368	10/19 (53%)
		zf-H2C2_2	464..488	CDD:290200	14/23 (61%)
		COG5048	475..>529	CDD:227381	27/53 (51%)
		C2H2 Zn finger	479..499	CDD:275368	9/19 (47%)
		zf-H2C2_2	491..515	CDD:290200	11/23 (48%)
		C2H2 Zn finger	507..527	CDD:275368	6/19 (32%)
Zfp112	XP_036009176.1	KRAB	12..72	CDD:214630
		COG5048	251..716	CDD:227381	128/508 (25%)
		C2H2 Zn finger	481..498	CDD:275368	1/16 (6%)
		C2H2 Zn finger	529..549	CDD:275368	4/19 (21%)
		C2H2 Zn finger	557..577	CDD:275368	9/69 (13%)
		C2H2 Zn finger	585..605	CDD:275368	6/23 (26%)
		C2H2 Zn finger	613..633	CDD:275368	7/19 (37%)
		C2H2 Zn finger	641..661	CDD:275368	9/19 (47%)
		C2H2 Zn finger	669..689	CDD:275368	8/19 (42%)
		COG5048	<674..842	CDD:227381	50/102 (49%)
		C2H2 Zn finger	697..717	CDD:275368	10/19 (53%)
		C2H2 Zn finger	725..745	CDD:275368	9/19 (47%)
		C2H2 Zn finger	753..773	CDD:275368	6/19 (32%)
		C2H2 Zn finger	781..801	CDD:275368
		C2H2 Zn finger	809..829	CDD:275368
		C2H2 Zn finger	837..857	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910