DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Clamp and Zfp90

DIOPT Version :9

Sequence 1:	NP_001014498.1	Gene:	Clamp / 35445	FlyBaseID:	FBgn0032979	Length:	566	Species:	Drosophila melanogaster
Sequence 2:	NP_001020936.1	Gene:	Zfp90 / 498945	RGDID:	1563077	Length:	633	Species:	Rattus norvegicus

Alignment Length:	549	Identity:	136/549 - (24%)
Similarity:	202/549 - (36%)	Gaps:	190/549 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    94 GAALGIATVDAQGRIQIVNQNKPIAANTISN------------------ISFKCDVCSDMFPHLA 140
            |...|::| |...::.:.:..:|....|..|                  ..:|||.|...|.|.:
  Rat   159 GEDSGLST-DLVPQLDVSSSIRPSECKTFGNNLEYNSELVTQSGIPAKKKPYKCDKCRKSFIHRS 222

  Fly   141 LLNAHKRMHTDGEQQQQQQHNAQAGGDSIAVVSAQGLVQAQNIIGNGQMGQIQIVSSDTLEPVQQ 205
            .||.|:::|.|         :|.:.|....|.|.
  Rat   223 SLNKHEKIHKD---------DAYSNGTDQGVPSG------------------------------- 247

  Fly   206 SVMQQQQHESKASKCINCGSSML-------QQSKRKGPKQVRCESCMQAEQTAQQQQQLFVAQDG 263
                ::.||     |.:||.:.|       .|....|.|...|..|.:|.:.:....|...|..|
  Rat   248 ----RKHHE-----CTDCGKTFLWRTQLTEHQRIHTGEKPFECNVCGKAFRHSSSLGQHENAHTG 303

  Fly   264 QMAHPVQIISTTPQAQAQLQQIVAAQTGGTTPKR--------EASSGSGHHPVKKRNSQQMTKCQ 320
            :..:...:.....|..:.|.|.....| |..|.|        ..|:....|.| ..:.::..:|:
  Rat   304 EKPYQCSLCGKAFQRSSSLVQHQRIHT-GEKPYRCNLCGRSFRHSTSLTQHEV-THSGEKPFQCK 366

  Fly   321 KCNG-----SGVVLVGQHSHASHSGVGGSVKQSVTVKTECLSCRNPSKPFSCNICGGLFSRYSSL 380
            :|..     |.:|   ||.. :|:|                     .|||.|:|||..|.:..||
  Rat   367 ECGKAFSRCSSLV---QHER-THTG---------------------EKPFECSICGRAFGQSPSL 406

  Fly   381 W--------------------------------------------------------SHKKLHSG 389
            :                                                        .|:::|:|
  Rat   407 YKHMRIHKRSKPYQSNNFSIAFEPNIPLTQGESVLTDVKSYHCIDCGKDFSHITDFTEHQRIHAG 471

  Fly   390 -------------------EKNYKCSICGLAFAKAVYLKNHARIHTGEKPYKCQTCGMQFSQSPH 435
                               ||.|:|::||.||.::.....|.|||||||||:|..||..||:...
  Rat   472 ENSYDSEQALRQQSLSHPREKPYQCNVCGKAFKRSTSFIEHHRIHTGEKPYECNECGEAFSRLSS 536

  Fly   436 LKNHERTHSGERPYVCGVCDKGFARHATLWNHRRIHTGEKPYKCEICGSAFSQAAHLKNHAKVHS 500
            |..|||||:||:||.|..|.|.|::.::|..|.|.|||||||:|..||.||.:..:|.:|.::|:
  Rat   537 LTQHERTHTGEKPYECIDCGKAFSQSSSLIQHERTHTGEKPYECNECGRAFRKKTNLHDHQRIHT 601

  Fly   501 GEKPYKCEICSAAFADRFALKRHRGIHQK 529
            |||||.|:.|...|:...||.:|..||.:
  Rat   602 GEKPYACKECGKNFSRSSALTKHHRIHSR 630

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Clamp	NP_001014498.1	COG5048	<359..498	CDD:227381	67/213 (31%)
		C2H2 Zn finger	367..387	CDD:275368	8/75 (11%)
		zf-H2C2_2	379..403	CDD:290200	12/98 (12%)
		C2H2 Zn finger	395..415	CDD:275368	7/19 (37%)
		zf-H2C2_2	407..432	CDD:290200	14/24 (58%)
		C2H2 Zn finger	423..443	CDD:275368	9/19 (47%)
		zf-H2C2_2	435..460	CDD:290200	14/24 (58%)
		C2H2 Zn finger	451..471	CDD:275368	7/19 (37%)
		zf-H2C2_2	464..488	CDD:290200	15/23 (65%)
		COG5048	475..>529	CDD:227381	24/53 (45%)
		C2H2 Zn finger	479..499	CDD:275368	7/19 (37%)
		zf-H2C2_2	491..515	CDD:290200	10/23 (43%)
		C2H2 Zn finger	507..527	CDD:275368	6/19 (32%)
Zfp90	NP_001020936.1	KRAB	14..74	CDD:214630
		KRAB	14..53	CDD:279668
		COG5048	198..625	CDD:227381	126/502 (25%)
		C2H2 Zn finger	211..231	CDD:275368	8/19 (42%)
		C2H2 Zn finger	253..273	CDD:275368	5/19 (26%)
		zf-H2C2_2	266..290	CDD:290200	6/23 (26%)
		C2H2 Zn finger	281..301	CDD:275368	4/19 (21%)
		C2H2 Zn finger	309..329	CDD:275368	3/19 (16%)
		zf-H2C2_2	321..346	CDD:290200	6/25 (24%)
		C2H2 Zn finger	337..357	CDD:275368	3/20 (15%)
		zf-H2C2_2	349..374	CDD:290200	4/25 (16%)
		C2H2 Zn finger	365..385	CDD:275368	6/23 (26%)
		zf-H2C2_2	377..400	CDD:290200	12/47 (26%)
		C2H2 Zn finger	393..413	CDD:275368	7/19 (37%)
		C2H2 Zn finger	449..469	CDD:275368	1/19 (5%)
		C2H2 Zn finger	496..516	CDD:275368	7/19 (37%)
		zf-H2C2_2	511..533	CDD:290200	14/21 (67%)
		C2H2 Zn finger	524..544	CDD:275368	9/19 (47%)
		zf-H2C2_2	536..561	CDD:290200	14/24 (58%)
		C2H2 Zn finger	552..572	CDD:275368	7/19 (37%)
		zf-H2C2_2	564..587	CDD:290200	13/22 (59%)
		C2H2 Zn finger	580..600	CDD:275368	7/19 (37%)
		zf-H2C2_2	596..617	CDD:290200	10/20 (50%)
		C2H2 Zn finger	608..628	CDD:275368	6/19 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24381
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010