DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Clamp and sens

DIOPT Version :9

Sequence 1:	NP_001014498.1	Gene:	Clamp / 35445	FlyBaseID:	FBgn0032979	Length:	566	Species:	Drosophila melanogaster
Sequence 2:	NP_524818.1	Gene:	sens / 45328	FlyBaseID:	FBgn0002573	Length:	541	Species:	Drosophila melanogaster

Alignment Length:	389	Identity:	99/389 - (25%)
Similarity:	137/389 - (35%)	Gaps:	140/389 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   118 AANTISNISFKCDVCSDMFPH------------LALLNAHKRMHTDGEQQQQQQHNAQAGGDSIA 170
            |:|.:.::.|:. ....::.|            |.||..|.::.::..|||||||..:.
  Fly   271 ASNAVQDLEFEV-AQQQLYAHRSAFMAGLTGNNLELLTQHLKLKSEQPQQQQQQHRIKD------ 328

  Fly   171 VVSAQGLVQAQNIIGNGQMGQIQIVSSDTLEPVQQSVMQQQQHESKASKCINCGSSMLQQSKRKG 235
                                                  :|||....|:..:|..::......|.
  Fly   329 --------------------------------------EQQQDNRSAAALMNLVAAAEFGYMRN- 354

  Fly   236 PKQVRCESCMQAEQTAQQQQQLFVAQDGQMAHPVQIISTTPQAQAQLQQIVAAQTGGTTPKREAS 300
                      |.:|..|||||       |:.|..|     || |.|.||.....|.....:|.:|
  Fly   355 ----------QHQQPQQQQQQ-------QLHHQQQ-----PQ-QHQHQQQHPDSTATDVARRSSS 396

  Fly   301 SGS--GHHPVKKRNSQQMTKCQKCNGSGVVLVGQHSHASHSGVGGSVKQSVTVKTECLSCRNPSK 363
            |.|  |.:..|:                                              |.||
  Fly   397 SSSYQGENEEKR----------------------------------------------SGRN--- 412

  Fly   364 PFSCNICGGLFSRYSSLWSHKKLHSGEKNYKCSICGLAFAKAVYLKNHARIHTGEKPYKCQTCGM 428
             |.|..||..|.|.|:|.:|..:||..:.|.|..||..|.:...:|.|..|||||||:||..|..
  Fly   413 -FQCKQCGKSFKRSSTLSTHLLIHSDTRPYPCQYCGKRFHQKSDMKKHTYIHTGEKPHKCTVCLK 476

  Fly   429 QFSQSPHLKNHERTHSGERPYVCGVCDKGFARHATLWNHRRIHTGE-------KPYKCEICGSA 485
            .||||.:|..|.|.|:|.:|:.|.:||:.|.|...|..||.....|       ||.|.|:..|:
  Fly   477 AFSQSSNLITHMRKHTGYKPFGCHLCDQSFQRKVDLRRHRESRHEEAPPVEDLKPLKMEVSSSS 540

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Clamp	NP_001014498.1	COG5048	<359..498	CDD:227381	54/134 (40%)
		C2H2 Zn finger	367..387	CDD:275368	8/19 (42%)
		zf-H2C2_2	379..403	CDD:290200	8/23 (35%)
		C2H2 Zn finger	395..415	CDD:275368	6/19 (32%)
		zf-H2C2_2	407..432	CDD:290200	13/24 (54%)
		C2H2 Zn finger	423..443	CDD:275368	9/19 (47%)
		zf-H2C2_2	435..460	CDD:290200	10/24 (42%)
		C2H2 Zn finger	451..471	CDD:275368	8/19 (42%)
		zf-H2C2_2	464..488	CDD:290200	9/29 (31%)
		COG5048	475..>529	CDD:227381	5/11 (45%)
		C2H2 Zn finger	479..499	CDD:275368	2/7 (29%)
		zf-H2C2_2	491..515	CDD:290200
		C2H2 Zn finger	507..527	CDD:275368
sens	NP_524818.1	zf-C2H2	413..435	CDD:278523	9/21 (43%)
		C2H2 Zn finger	415..435	CDD:275368	8/19 (42%)
		COG5048	423..>497	CDD:227381	32/73 (44%)
		zf-H2C2_2	428..452	CDD:290200	9/23 (39%)
		C2H2 Zn finger	443..463	CDD:275368	6/19 (32%)
		zf-H2C2_2	455..480	CDD:290200	13/24 (54%)
		C2H2 Zn finger	471..491	CDD:275368	9/19 (47%)
		C2H2 Zn finger	499..516	CDD:275368	6/16 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	44	1.000	Inparanoid score	I2683
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.960