DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Clamp and Zif

DIOPT Version :9

Sequence 1:	NP_001014498.1	Gene:	Clamp / 35445	FlyBaseID:	FBgn0032979	Length:	566	Species:	Drosophila melanogaster
Sequence 2:	NP_001189188.1	Gene:	Zif / 40795	FlyBaseID:	FBgn0037446	Length:	388	Species:	Drosophila melanogaster

Alignment Length:	316	Identity:	80/316 - (25%)
Similarity:	123/316 - (38%)	Gaps:	52/316 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   220 CINC--GSSMLQQSKRKG-PKQVRCES-CMQAEQTAQQQQQLFVAQDGQMAHPVQIISTTPQAQA 280
            |.:|  ..:|..|.:.|. .||:..|. |.:.....:....:...:||.            |.|.
  Fly    60 CKSCKVELNMAYQFREKALRKQMEIEEYCRELGLLDESDVMMIKEEDGS------------QQQC 112

  Fly   281 QLQQIVAAQTGGTTPKREASSGSGHHPVKKRNSQQMTKC---------------QKCNGSGVVLV 330
            ..:..:..:|  ||.:.|.....||....:.::....:|               ...:.:.:||.
  Fly   113 DEEMYILEET--TTGEEEHQEEKGHEEYLEVDTSDQQECIGDTIEYLEDNYTIEMNSDQTEIVLE 175

  Fly   331 GQHSH---------------ASHSGVGGSVKQSVTVKTECLSCRNPSKPFSCNICGGLFSRYSSL 380
            .:..:               ||.....|.|::.:...|  .|.......:.|::||..:.:...:
  Fly   176 SEKQYEETPSQQLALQEAAKASLKARRGRVRRGLNSLT--TSDGTEKGGYICDVCGNFYEKRGRM 238

  Fly   381 WSHKKLHSGEKNYKCSICGLAFAKAVYLKNHARIHTGEKPYKCQTCGMQFSQSPHLKNHERTHSG 445
            ..|::.|.|...|.|.:|...|.....|:.|...|||.|||||..|..||.....||:||..|.|
  Fly   239 MEHRRRHDGICQYACELCDAKFQVREQLRKHMYSHTGSKPYKCSFCSRQFFYESVLKSHENVHRG 303

  Fly   446 ERPYVCGVCDKGFARHATLWNHRRIHTGEKPYKCEICGSAFSQAAHLKNH--AKVH 499
            .:||||.||||.||...:|..|..||:..|.|:|:.|...|....|::.|  .|:|
  Fly   304 IKPYVCKVCDKAFAYAHSLTKHELIHSDIKLYRCDYCNKDFRLLHHMRQHEETKLH 359

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Clamp	NP_001014498.1	COG5048	<359..498	CDD:227381	50/140 (36%)
		C2H2 Zn finger	367..387	CDD:275368	4/19 (21%)
		zf-H2C2_2	379..403	CDD:290200	6/23 (26%)
		C2H2 Zn finger	395..415	CDD:275368	5/19 (26%)
		zf-H2C2_2	407..432	CDD:290200	13/24 (54%)
		C2H2 Zn finger	423..443	CDD:275368	8/19 (42%)
		zf-H2C2_2	435..460	CDD:290200	15/24 (63%)
		C2H2 Zn finger	451..471	CDD:275368	9/19 (47%)
		zf-H2C2_2	464..488	CDD:290200	9/23 (39%)
		COG5048	475..>529	CDD:227381	9/27 (33%)
		C2H2 Zn finger	479..499	CDD:275368	6/21 (29%)
		zf-H2C2_2	491..515	CDD:290200	4/11 (36%)
		C2H2 Zn finger	507..527	CDD:275368
Zif	NP_001189188.1	zf-AD	9..87	CDD:285071	8/26 (31%)
		C2H2 Zn finger	225..245	CDD:275368	4/19 (21%)
		COG5048	<250..369	CDD:227381	46/110 (42%)
		C2H2 Zn finger	253..273	CDD:275368	5/19 (26%)
		zf-H2C2_2	266..288	CDD:290200	11/21 (52%)
		C2H2 Zn finger	281..301	CDD:275368	8/19 (42%)
		zf-H2C2_2	294..318	CDD:290200	15/23 (65%)
		C2H2 Zn finger	309..329	CDD:275368	9/19 (47%)
		C2H2 Zn finger	337..353	CDD:275368	4/15 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910