Protein Alignment Clamp and ZNF470

DIOPT Version :10

• Sequence 1: NP_001014498.1
• Gene: Clamp / 35445
• FlyBaseID: FBgn0032979
• Length: 566
• Species: Drosophila melanogaster
• Sequence 2: NP_001001668.3
• Gene: ZNF470 / 388566
• HGNCID: 22220
• Length: 717
• Species: Homo sapiens
• Alignment Length: 472
• Identity: 140/472 - (29%)
• Similarity: 203/472 - (43%)
• Gaps: 138/472 - (29%)

  Fly   128 KCDVCSDMFPHLALLNAHKRMHTD---------GEQQQQQQHNAQAGGDSIAVVSAQGLVQAQNI 183
            ||:.|..:|..::.|..|:|:||.         |:...|..|.||
Human   229 KCNDCEKIFSKISTLTLHQRIHTGEKPYECIECGKAFSQSAHLAQ-------------------- 273

  Fly   184 IGNGQMGQIQIVSSDTLEPVQQSVMQQQQHE-SKASKCINCGSSMLQ-------QSKRKGPKQVR 240
                                     .|:.|. .|..:|..||.:..|       |....|.|..:
Human   274 -------------------------HQRIHTGEKPFECTECGKAFSQNAHLVQHQRVHTGEKPYQ 313

  Fly   241 CESCMQAEQTAQQQQQLFVAQDGQMAHPVQIISTTPQAQAQLQQIVAAQTGGTTPKR-------- 297
            |:.|.:|              ..|:||           .||.|::..    |..|..
Human   314 CKQCNKA--------------FSQLAH-----------LAQHQRVHT----GEKPYECIECGKAF 349

  Fly   298 -EASSGSGHHPVKK-RNSQQMTKCQKCNGSGVVLVGQHSHASHSGVGGSVKQSVTVKTECLSC-- 358
             :.||.:.|..:.. :...:...|.|.......|: :|....|:|         ....:|:.|
Human   350 SDCSSLAHHRRIHTGKRPYECIDCGKAFRQNASLI-RHRRYYHTG---------EKPFDCIDCGK 404

  Fly   359 --------------RNPSKPFSCNICGGLFSRYSSLWSHKKLHSGEKNYKCSICGLAFAKAVYLK 409
                          ....:|:.||:||..||..|||..|:::|:|||.|:|:||..||:....|.
Human   405 AFTDHIGLIQHKRTHTGERPYKCNVCGKAFSHGSSLTVHQRIHTGEKPYECNICEKAFSHRGSLT 469

  Fly   410 NHARIHTGEKPYKCQTCGMQFSQSPHLKNHERTHSGERPYVCGVCDKGFARHATLWNHRRIHTGE 474
            .|.|:|||||||:|:.||..|.||.||.:|:|.|:||:||.|..|.|.|:::|.|..|::|||||
Human   470 LHQRVHTGEKPYECKECGKAFRQSTHLAHHQRIHTGEKPYECKECSKTFSQNAHLAQHQKIHTGE 534

  Fly   475 KPYKCEICGSAFSQAAHLKNHAKVHSGEKPYKCEICSAAFADRFALKRHRGIHQ--------KYG 531
            |||:|:.||.||||.|||..|.:||:|||||:|..|..||:|...|.:|:.:|.        :.|
Human   535 KPYECKECGKAFSQIAHLVQHQRVHTGEKPYECIECGKAFSDGSYLVQHQRLHSGKRPYECLECG 599

  Fly   532 QTAPRQTSSDGMIVHKQ 548
            : |.||.:|  :|.|::
Human   600 K-AFRQRAS--LICHQR 613

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Clamp	NP_001014498.1	COG5048	<359..498	CDD:227381	72/138 (52%)
		C2H2 Zn finger	367..387	CDD:275368	10/19 (53%)
		C2H2 Zn finger	395..415	CDD:275368	8/19 (42%)
		zf-H2C2_2	407..432	CDD:463886	14/24 (58%)
		C2H2 Zn finger	423..443	CDD:275368	10/19 (53%)
		C2H2 Zn finger	451..471	CDD:275368	7/19 (37%)
		COG5048	475..>529	CDD:227381	29/61 (48%)
		C2H2 Zn finger	479..499	CDD:275368	11/19 (58%)
		C2H2 Zn finger	507..527	CDD:275368	7/19 (37%)
ZNF470	NP_001001668.3	KRAB	23..83	CDD:214630
		Nuclear localization signal. /evidence=ECO:0000255	216..219
		C2H2 Zn finger	230..250	CDD:275368	6/19 (32%)
		COG5048	254..669	CDD:227381	131/447 (29%)
		C2H2 Zn finger	258..278	CDD:275368	6/64 (9%)
		C2H2 Zn finger	286..306	CDD:275368	5/19 (26%)
		C2H2 Zn finger	314..334	CDD:275368	9/44 (20%)
		C2H2 Zn finger	342..362	CDD:275368	3/19 (16%)
		C2H2 Zn finger	370..388	CDD:275368	4/18 (22%)
		Nuclear localization signal. /evidence=ECO:0000255	385..388		1/2 (50%)
		C2H2 Zn finger	399..419	CDD:275368	2/19 (11%)
		C2H2 Zn finger	427..447	CDD:275368	10/19 (53%)
		C2H2 Zn finger	455..475	CDD:275368	8/19 (42%)
		C2H2 Zn finger	483..503	CDD:275368	10/19 (53%)
		C2H2 Zn finger	511..531	CDD:275368	7/19 (37%)
		C2H2 Zn finger	539..559	CDD:275368	11/19 (58%)
		C2H2 Zn finger	567..587	CDD:275368	7/19 (37%)
		C2H2 Zn finger	595..615	CDD:275368	7/22 (32%)
		C2H2 Zn finger	623..643	CDD:275368
		C2H2 Zn finger	651..671	CDD:275368
		zf-H2C2_2	663..688	CDD:463886
		C2H2 Zn finger	679..699	CDD:275368