DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Clamp and ikzf1

DIOPT Version :9

Sequence 1:	NP_001014498.1	Gene:	Clamp / 35445	FlyBaseID:	FBgn0032979	Length:	566	Species:	Drosophila melanogaster
Sequence 2:	XP_005156674.1	Gene:	ikzf1 / 30177	ZFINID:	ZDB-GENE-980526-304	Length:	641	Species:	Danio rerio

Alignment Length:	368	Identity:	80/368 - (21%)
Similarity:	119/368 - (32%)	Gaps:	150/368 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly   147 RMHTDGEQQQQQ------QHNAQAGGDSIAVVSAQGLVQAQNIIGNGQMGQIQIVSSDTLEPVQQ 205
            ||.|:..|:..|      ..||..||:                            ..|...||.:
Zfish   104 RMETEEAQEMSQITGRDSPMNANEGGE----------------------------DQDEAMPVPE 140

  Fly   206 --SVMQQQQHESKASKCINCGSSMLQQSKRKGPKQVRCESCMQAEQTAQQQQQLFVAQDGQMAHP 268
              |.....||.::..|.:.|...:..:|..:  ..:.||...:||:.|.:..::.
Zfish   141 DLSASTGLQHNNRTDKPLACNIKVEARSDEE--NGLSCEMNGEAEECAAEDLRIL---------- 193

  Fly   269 VQIISTTPQAQAQLQQIVAAQTGGTTPKREASSGSGHHPVKKRNSQQMTKCQKCNGSGVVLVGQH 333
                                            .|||               .|.||
Zfish   194 --------------------------------DGSG---------------AKVNG--------- 202

  Fly   334 SHASHSGVGGSVKQSVTVKTECLSCRNPSKPFSCNICGGLFSRYSSLWSHKKLHSGEKNYKCSIC 398
               ||:|                   ..|||.:....||:           :|.:|:  .||.||
Zfish   203 ---SHAG-------------------PDSKPAAYPTAGGI-----------RLPNGK--LKCDIC 232

  Fly   399 GLAFAKAVYLKNHARIHT-----------GEKPYKCQTCGMQFSQSPHLKNHERTHSGERPYVCG 452
            |:.......|..|.|.||           ||:|::|..||..|:|..:|..|.:.||||:|:.|.
Zfish   233 GIVCIGPNVLMVHKRSHTEERKSVLEQQKGERPFQCNQCGASFTQKGNLLRHIKLHSGEKPFKCH 297

  Fly   453 VCDKGFARHATLWNHRRIHTGEKPYKCEICGSAFSQAAHLKNH 495
            :|:....|...|..|.|.|:..||:||..||.::.|.:.|:.|
Zfish   298 LCNYACRRRDALTGHLRTHSVGKPHKCAYCGRSYKQRSSLEEH 340

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Clamp	NP_001014498.1	COG5048	<359..498	CDD:227381	48/148 (32%)
		C2H2 Zn finger	367..387	CDD:275368	2/19 (11%)
		zf-H2C2_2	379..403	CDD:290200	7/23 (30%)
		C2H2 Zn finger	395..415	CDD:275368	7/19 (37%)
		zf-H2C2_2	407..432	CDD:290200	12/35 (34%)
		C2H2 Zn finger	423..443	CDD:275368	7/19 (37%)
		zf-H2C2_2	435..460	CDD:290200	9/24 (38%)
		C2H2 Zn finger	451..471	CDD:275368	6/19 (32%)
		zf-H2C2_2	464..488	CDD:290200	10/23 (43%)
		COG5048	475..>529	CDD:227381	9/21 (43%)
		C2H2 Zn finger	479..499	CDD:275368	6/17 (35%)
		zf-H2C2_2	491..515	CDD:290200	2/5 (40%)
		C2H2 Zn finger	507..527	CDD:275368
ikzf1	XP_005156674.1	C2H2 Zn finger	229..249	CDD:275368	7/19 (37%)
		COG5048	<236..>339	CDD:227381	35/102 (34%)
		zf-H2C2_2	242..277	CDD:290200	12/34 (35%)
		zf-C2H2	266..288	CDD:278523	7/21 (33%)
		C2H2 Zn finger	268..288	CDD:275368	7/19 (37%)
		zf-H2C2_2	280..305	CDD:290200	9/24 (38%)
		C2H2 Zn finger	296..316	CDD:275368	6/19 (32%)
		zf-H2C2_2	312..333	CDD:290200	9/20 (45%)
		C2H2 Zn finger	324..345	CDD:275368	6/17 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910