DRSC/TRiP Functional Genomics Resources

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Protein Alignment Clamp and IKZF3

DIOPT Version :9

Sequence 1:NP_001014498.1 Gene:Clamp / 35445 FlyBaseID:FBgn0032979 Length:566 Species:Drosophila melanogaster
Sequence 2:NP_036613.2 Gene:IKZF3 / 22806 HGNCID:13178 Length:509 Species:Homo sapiens


Alignment Length:219 Identity:68/219 - (31%)
Similarity:102/219 - (46%) Gaps:41/219 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly   344 SVKQSVTVKTECL-SCRNPSKPFSCNICGGLFSRYSSLWSHKKLH------------SGEKNYKC 395
            |.:....:|:|.: :...|..|:|       :||..:.:.:.||.            ||:.|  |
Human    65 SERDENVLKSEPMGNAEEPEIPYS-------YSREYNEYENIKLERHVVSFDSSRPTSGKMN--C 120

  Fly   396 SICGLAFAKAVYLKNHARIHTGEKPYKCQTCGMQFSQSPHLKNHERTHSGERPYVCGVCDKGFAR 460
            .:|||:......|..|.|.||||:|::|..||..|:|..:|..|.:.|:||:|:.|.:|:....|
Human   121 DVCGLSCISFNVLMVHKRSHTGERPFQCNQCGASFTQKGNLLRHIKLHTGEKPFKCHLCNYACQR 185

  Fly   461 HATLWNHRRIHTGEKPYKCEICGSAFSQAAHLKNHAK-------------VHSGE-KPYKCEICS 511
            ...|..|.|.|:.|||||||.||.::.|.:.|:.|.:             ..|.| :..|.|:.|
Human   186 RDALTGHLRTHSVEKPYKCEFCGRSYKQRSSLEEHKERCRTFLQSTDPGDTASAEARHIKAEMGS 250

  Fly   512 --AAFADRFA---LKRHRGIHQKY 530
              |...||.|   .||...:.||:
Human   251 ERALVLDRLASNVAKRKSSMPQKF 274

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ClampNP_001014498.1 COG5048 <359..498 CDD:227381 52/163 (32%)
C2H2 Zn finger 367..387 CDD:275368 3/19 (16%)
zf-H2C2_2 379..403 CDD:290200 9/35 (26%)
C2H2 Zn finger 395..415 CDD:275368 7/19 (37%)
zf-H2C2_2 407..432 CDD:290200 12/24 (50%)
C2H2 Zn finger 423..443 CDD:275368 7/19 (37%)
zf-H2C2_2 435..460 CDD:290200 8/24 (33%)
C2H2 Zn finger 451..471 CDD:275368 6/19 (32%)
zf-H2C2_2 464..488 CDD:290200 13/23 (57%)
COG5048 475..>529 CDD:227381 22/72 (31%)
C2H2 Zn finger 479..499 CDD:275368 7/32 (22%)
zf-H2C2_2 491..515 CDD:290200 8/39 (21%)
C2H2 Zn finger 507..527 CDD:275368 8/24 (33%)
IKZF3NP_036613.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..86 4/20 (20%)
COG5048 <79..>219 CDD:227381 51/148 (34%)
C2H2 Zn finger 120..140 CDD:275368 7/19 (37%)
zf-H2C2_2 133..157 CDD:316026 12/23 (52%)
C2H2 Zn finger 148..168 CDD:275368 7/19 (37%)
C2H2 Zn finger 176..196 CDD:275368 6/19 (32%)
C2H2 Zn finger 204..220 CDD:275368 6/15 (40%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 364..394
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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