DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Clamp and Ikzf3

DIOPT Version :9

Sequence 1:	NP_001014498.1	Gene:	Clamp / 35445	FlyBaseID:	FBgn0032979	Length:	566	Species:	Drosophila melanogaster
Sequence 2:	NP_035901.1	Gene:	Ikzf3 / 22780	MGIID:	1342542	Length:	507	Species:	Mus musculus

Alignment Length:	185	Identity:	60/185 - (32%)
Similarity:	89/185 - (48%)	Gaps:	32/185 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   374 FSRYSSL-------WSHKKLHSGEKNYKCSICGLAFAKAVYLKNHARIHTGEKPYKCQTCGMQFS 431
            :|.|.|:       :.:.:...|:.|  |.:|||:......|..|.|.||||:|::|..||..|:
Mouse    93 YSDYESIKLERHVPYDNSRPTGGKMN--CDVCGLSCISFNVLMVHKRSHTGERPFQCNQCGASFT 155

  Fly   432 QSPHLKNHERTHSGERPYVCGVCDKGFARHATLWNHRRIHTGEKPYKCEICGSAFSQAAHLKNH- 495
            |..:|..|.:.|:||:|:.|.:|:....|...|..|.|.|:.|||||||.||.::.|.:.|:.|
Mouse   156 QKGNLLRHIKLHTGEKPFKCHLCNYACQRRDALTGHLRTHSVEKPYKCEFCGRSYKQRSSLEEHK 220

  Fly   496 ---------------AKVHSGEKPYKCEICS--AAFADRFA---LKRHRGIHQKY 530
                           |.|.:  :..|.|:.|  |...||.|   .||...:.||:
Mouse   221 ERCRAFLQNPDLGDAASVEA--RHIKAEMGSERALVLDRLASNVAKRKSSMPQKF 273

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Clamp	NP_001014498.1	COG5048	<359..498	CDD:227381	48/146 (33%)
		C2H2 Zn finger	367..387	CDD:275368	3/19 (16%)
		zf-H2C2_2	379..403	CDD:290200	7/30 (23%)
		C2H2 Zn finger	395..415	CDD:275368	7/19 (37%)
		zf-H2C2_2	407..432	CDD:290200	12/24 (50%)
		C2H2 Zn finger	423..443	CDD:275368	7/19 (37%)
		zf-H2C2_2	435..460	CDD:290200	8/24 (33%)
		C2H2 Zn finger	451..471	CDD:275368	6/19 (32%)
		zf-H2C2_2	464..488	CDD:290200	13/23 (57%)
		COG5048	475..>529	CDD:227381	22/74 (30%)
		C2H2 Zn finger	479..499	CDD:275368	8/35 (23%)
		zf-H2C2_2	491..515	CDD:290200	8/41 (20%)
		C2H2 Zn finger	507..527	CDD:275368	8/24 (33%)
Ikzf3	NP_035901.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..85
		COG5048	<105..>218	CDD:227381	43/114 (38%)
		C2H2 Zn finger	119..139	CDD:275368	7/19 (37%)
		zf-H2C2_2	132..156	CDD:290200	12/23 (52%)
		C2H2 Zn finger	147..167	CDD:275368	7/19 (37%)
		zf-H2C2_2	159..182	CDD:290200	8/22 (36%)
		C2H2 Zn finger	175..195	CDD:275368	6/19 (32%)
		zf-H2C2_2	191..212	CDD:290200	12/20 (60%)
		C2H2 Zn finger	203..219	CDD:275368	6/15 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	370..396
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910