DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Clamp and Zscan2

DIOPT Version :9

Sequence 1:	NP_001014498.1	Gene:	Clamp / 35445	FlyBaseID:	FBgn0032979	Length:	566	Species:	Drosophila melanogaster
Sequence 2:	NP_001369440.1	Gene:	Zscan2 / 22691	MGIID:	99176	Length:	614	Species:	Mus musculus

Alignment Length:	596	Identity:	155/596 - (26%)
Similarity:	230/596 - (38%)	Gaps:	161/596 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MEDLTKNIIFTNAINGQPATIQYQTADGTILKQPKIEGQKTEQQPTFYYTTNGNGGTVNLAQLAT 65
            :||||:..        :.:..:.|:.:|....:...||  .|....|...:.|.||..:...
Mouse   124 VEDLTQTF--------RHSDFEIQSENGENSNEDMFEG--VESHGMFLNISGGEGGQQSDGD--- 175

  Fly    66 TDDNKTCYIAQPVGGYNYALVNGMPLNQGAALGIA------TVDAQGRIQIVNQNKPIAANTISN 124
            :|..:.|                   ..|.|.|.|      .|.::||  .|.|...:....:..
Mouse   176 SDFERDC-------------------GSGGAQGHAPGEDPRVVPSEGR--EVGQLIGLQGTYLGE 219

  Fly   125 ISFKCDVCSDMFPHLALLNAHKRMHT---------------DGE--QQQQQQHNAQAG------G 166
            ..::|..|...|...:.|..|:|.||               ||.  .:.|..|..:..      |
Mouse   220 KPYECPQCGKTFSRKSHLITHERTHTGEKYYKCDECGKSFSDGSNFSRHQTTHTGEKPYKCRDCG 284

  Fly   167 DSIAVVSAQGLVQAQNIIGNGQMGQIQIVSSDTLEPVQQS---VMQQQQHE-SKASKCINCGSSM 227
            .|.:  .:..|:..|.|    ..|:.....::..:...:|   :..|:.|. .|...|..||.|.
Mouse   285 KSFS--RSANLITHQRI----HTGEKPFQCAECGKSFSRSPNLIAHQRTHTGEKPYSCPECGKSF 343

  Fly   228 -------LQQSKRKGPKQVRCESCMQAEQTAQQQQQLFVAQDGQMAHPVQIISTTPQAQAQLQQI 285
                   ..|....|.|...|:.|.::          |......:.|  |.|.|
Mouse   344 GNRSSLNTHQGIHTGEKPYACKECGES----------FSYNSNLIRH--QRIHT----------- 385

  Fly   286 VAAQTGGTTPKREASSGSGHHPVKKRNSQQMTKC-QKCNGSGVVLVGQHSHASHSGVGGSVKQSV 349
                              |..|.|      .|:| ||.:.|..::..:.:|..
Mouse   386 ------------------GEKPYK------CTECGQKFSQSSALITHRRTHTG------------ 414

  Fly   350 TVKTECLSCRNPSKPFSCNICGGLFSRYSSLWSHKKLHSGEKNYKCSICGLAFAKAVYLKNHARI 414
                        .||:.|..||..|||.|:|.:|::.|..||.|||.:||.:|:::..|..|...
Mouse   415 ------------EKPYQCGECGKNFSRSSNLATHRRTHLVEKPYKCGLCGKSFSQSSSLIAHQGT 467

  Fly   415 HTGEKPYKCQTCGMQFSQSPHLKNHERTHSGERPYVCGVCDKGFARHATLWNHRRIHTGEKPYKC 479
            |||||||:|.|||..||.|.:|..|:|||:||:||.||.|.|||::.:.|..|:|.|||||||||
Mouse   468 HTGEKPYECLTCGESFSWSSNLIKHQRTHTGEKPYRCGDCGKGFSQRSQLVVHQRTHTGEKPYKC 532

  Fly   480 EICGSAFSQAAHLKNHAKVHSGEKPYKCEICSAAFADRFALKRHRGIHQKYGQTAPR-------Q 537
            .:||.:||:.:.|..|.:.|.|:|||:|..|...|:....|..|:.||.  |:...|       .
Mouse   533 LMCGKSFSRGSILVMHQRAHLGDKPYRCPECGKGFSWNSVLIIHQRIHT--GEKPYRCPECGKGF 595

  Fly   538 TSSDGMIVHKQ 548
            ::|...|.|::
Mouse   596 SNSSNFITHQR 606

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Clamp	NP_001014498.1	COG5048	<359..498	CDD:227381	69/138 (50%)
		C2H2 Zn finger	367..387	CDD:275368	9/19 (47%)
		zf-H2C2_2	379..403	CDD:290200	10/23 (43%)
		C2H2 Zn finger	395..415	CDD:275368	6/19 (32%)
		zf-H2C2_2	407..432	CDD:290200	14/24 (58%)
		C2H2 Zn finger	423..443	CDD:275368	10/19 (53%)
		zf-H2C2_2	435..460	CDD:290200	15/24 (63%)
		C2H2 Zn finger	451..471	CDD:275368	9/19 (47%)
		zf-H2C2_2	464..488	CDD:290200	15/23 (65%)
		COG5048	475..>529	CDD:227381	23/53 (43%)
		C2H2 Zn finger	479..499	CDD:275368	7/19 (37%)
		zf-H2C2_2	491..515	CDD:290200	9/23 (39%)
		C2H2 Zn finger	507..527	CDD:275368	5/19 (26%)
Zscan2	NP_001369440.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..25
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	42..73
		SCAN	69..131	CDD:396558	4/6 (67%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	162..200		9/59 (15%)
		COG5048	220..600	CDD:227381	129/458 (28%)
		C2H2 Zn finger	224..244	CDD:275368	6/19 (32%)
		C2H2 Zn finger	252..272	CDD:275368	3/19 (16%)
		C2H2 Zn finger	280..300	CDD:275368	5/25 (20%)
		C2H2 Zn finger	308..328	CDD:275368	2/19 (11%)
		C2H2 Zn finger	336..356	CDD:275368	5/19 (26%)
		C2H2 Zn finger	364..384	CDD:275368	5/31 (16%)
		C2H2 Zn finger	392..412	CDD:275368	5/19 (26%)
		C2H2 Zn finger	420..440	CDD:275368	9/19 (47%)
		C2H2 Zn finger	448..468	CDD:275368	6/19 (32%)
		C2H2 Zn finger	476..496	CDD:275368	10/19 (53%)
		C2H2 Zn finger	504..524	CDD:275368	9/19 (47%)
		C2H2 Zn finger	532..552	CDD:275368	7/19 (37%)
		C2H2 Zn finger	560..580	CDD:275368	5/19 (26%)
		C2H2 Zn finger	588..608	CDD:275368	3/19 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000