DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Clamp and AU041133

DIOPT Version :9

Sequence 1:	NP_001014498.1	Gene:	Clamp / 35445	FlyBaseID:	FBgn0032979	Length:	566	Species:	Drosophila melanogaster
Sequence 2:	NP_001156536.1	Gene:	AU041133 / 216177	MGIID:	2143755	Length:	498	Species:	Mus musculus

Alignment Length:	448	Identity:	136/448 - (30%)
Similarity:	193/448 - (43%)	Gaps:	106/448 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   106 GRIQIVNQNKPIAANTISNISFKCDVCSDMFPHLALLNAHKRMHTDGEQQQQQQHNAQAGGDSIA 170
            |||.  .:.||          ::|..||.:|.:...|..|::.||     :::.:.....|.|.
Mouse    97 GRIH--TEGKP----------YECKQCSQIFTNFCHLRKHEKKHT-----KEKLYECNHCGKSF- 143

  Fly   171 VVSAQGLVQAQNIIGNG-------QMGQIQIVSSDTLEPVQQSVMQQQQHE-SKASKCINCG--- 224
              .::..:|..|....|       :.|:....||:.|       :.::.|. .|...|.:||
Mouse   144 --PSRNSLQIHNRTHTGEKPYDCNECGKAFTCSSNLL-------LHKRTHTGEKPYDCSDCGKAF 199

  Fly   225 --SSMLQQSKRK--GPKQVRCESC---------MQAEQTAQQQQQLFVAQDGQMAHPVQIISTTP 276
              ||.||..|||  |.|...|..|         :|..:.:..:::::...
Mouse   200 ASSSNLQIHKRKHTGEKPYGCNQCGKAFAYSNALQKHERSHTREKIYECN--------------- 249

  Fly   277 QAQAQLQQIVAAQTGGTTPK-REASSGSGHHPVKKRNSQQMTKCQKCNGSGVVLVGQHSH-ASHS 339
                        |.|....: |...:...||.::|     ..:|.:|..:.......:.| .||:
Mouse   250 ------------QCGKAFARHRSLQNHEEHHTLEK-----PYECSQCGKAFAYSSNLYIHERSHT 297

  Fly   340 GVGGSVKQSVTVKTECLSCRNPSKPFSCNICGGLFSRYSSLWSHKKLHSGEKNYKCSICGLAFAK 404
            |                     .|||.|..||..|..:|||..|::.|:|||.|.|:.||.|||.
Mouse   298 G---------------------EKPFKCTQCGKAFPSHSSLQIHERTHTGEKPYDCNECGKAFAC 341

  Fly   405 AVYLKNHARIHTGEKPYKCQTCGMQFSQSPHLKNHERTHSGERPYVCGVCDKGFARHATLWNHRR 469
            ...|..|.|.|||||||.|..||..|:.|..|:.||:||:||:||.|..|.|.|||.:.|:.|.|
Mouse   342 RSNLLLHKRTHTGEKPYHCIECGKAFACSSSLQKHEKTHTGEKPYECNQCGKAFARRSDLYIHER 406

  Fly   470 IHTGEKPYKCEICGSAFSQAAHLKNHAKVHSGEKPYKCEICSAAFADRFALKRHRGIH 527
            ||||||||:|..||.||.....|:.|.:.|:|||||:|..|..||..||:|:.|...|
Mouse   407 IHTGEKPYECNQCGKAFVHCISLQRHERTHTGEKPYECNQCGKAFTRRFSLQVHERSH 464

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Clamp	NP_001014498.1	COG5048	<359..498	CDD:227381	70/138 (51%)
		C2H2 Zn finger	367..387	CDD:275368	8/19 (42%)
		zf-H2C2_2	379..403	CDD:290200	12/23 (52%)
		C2H2 Zn finger	395..415	CDD:275368	9/19 (47%)
		zf-H2C2_2	407..432	CDD:290200	14/24 (58%)
		C2H2 Zn finger	423..443	CDD:275368	8/19 (42%)
		zf-H2C2_2	435..460	CDD:290200	13/24 (54%)
		C2H2 Zn finger	451..471	CDD:275368	9/19 (47%)
		zf-H2C2_2	464..488	CDD:290200	16/23 (70%)
		COG5048	475..>529	CDD:227381	25/53 (47%)
		C2H2 Zn finger	479..499	CDD:275368	7/19 (37%)
		zf-H2C2_2	491..515	CDD:290200	11/23 (48%)
		C2H2 Zn finger	507..527	CDD:275368	8/19 (42%)
AU041133	NP_001156536.1	KRAB	4..>47	CDD:214630
		KRAB	4..43	CDD:279668
		COG5048	104..489	CDD:227381	133/439 (30%)
		C2H2 Zn finger	108..128	CDD:275368	6/19 (32%)
		C2H2 Zn finger	136..156	CDD:275368	4/22 (18%)
		zf-H2C2_2	148..173	CDD:290200	4/24 (17%)
		C2H2 Zn finger	164..184	CDD:275368	4/26 (15%)
		zf-H2C2_2	176..201	CDD:290200	6/31 (19%)
		C2H2 Zn finger	192..212	CDD:275368	9/19 (47%)
		zf-H2C2_2	204..229	CDD:290200	9/24 (38%)
		C2H2 Zn finger	220..240	CDD:275368	3/19 (16%)
		zf-H2C2_2	232..257	CDD:290200	3/51 (6%)
		C2H2 Zn finger	248..268	CDD:275368	3/46 (7%)
		C2H2 Zn finger	276..296	CDD:275368	3/19 (16%)
		zf-H2C2_2	288..311	CDD:290200	10/43 (23%)
		C2H2 Zn finger	304..324	CDD:275368	8/19 (42%)
		zf-H2C2_2	316..341	CDD:290200	13/24 (54%)
		C2H2 Zn finger	332..352	CDD:275368	9/19 (47%)
		zf-H2C2_2	344..369	CDD:290200	14/24 (58%)
		C2H2 Zn finger	360..380	CDD:275368	8/19 (42%)
		zf-H2C2_2	372..397	CDD:290200	13/24 (54%)
		C2H2 Zn finger	388..408	CDD:275368	9/19 (47%)
		zf-H2C2_2	400..425	CDD:290200	16/24 (67%)
		C2H2 Zn finger	416..436	CDD:275368	7/19 (37%)
		zf-H2C2_2	428..453	CDD:290200	12/24 (50%)
		C2H2 Zn finger	444..464	CDD:275368	8/19 (42%)
		zf-H2C2_2	456..481	CDD:290200	3/9 (33%)
		C2H2 Zn finger	472..492	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24381
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100