DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Clamp and ZNF675

DIOPT Version :9

Sequence 1:	NP_001014498.1	Gene:	Clamp / 35445	FlyBaseID:	FBgn0032979	Length:	566	Species:	Drosophila melanogaster
Sequence 2:	NP_612203.2	Gene:	ZNF675 / 171392	HGNCID:	30768	Length:	568	Species:	Homo sapiens

Alignment Length:	494	Identity:	146/494 - (29%)
Similarity:	210/494 - (42%)	Gaps:	107/494 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    79 GGYNYALVNGMPLNQGAALGIATVDAQGRIQIVN-------------QNKPIAANTISNISFKCD 130
            |||| .|...:|..|....     .....:::.|             :|||          |||.
Human   127 GGYN-GLNQCLPTMQSKMF-----QCDKYVKVFNKFSHSDRHKIKHMENKP----------FKCK 175

  Fly   131 VCSDMFPHLALLNAHKRMHT-----DGEQQQQQQHNAQAGGDSIAVVSAQGLVQAQNIIGNGQMG 190
            .|...|..|:.|..|:|.:|     ..|:.::            ||..:..|.:.:.|....::.
Human   176 ECGRSFCMLSHLTRHERNYTKVNFCKCEECEK------------AVNQSSKLTKHKRIYTCEKLY 228

  Fly   191 QIQIVSSDTLEPVQQSVMQQQQHESKASKCINCGSSMLQQSK-------RKGPKQVRCESCMQAE 248
            :.|.......:....:..::.....|..||..||.:..|.|.       ..|.|..:||.|
Human   229 KCQECDRTFNQFSNLTEYKKDYAREKPYKCEECGKAFNQSSHLTTHKIIHTGEKPYKCEEC---- 289

  Fly   249 QTAQQQQQLFVAQDGQMAHPVQIISTTPQAQAQLQQIVAAQTGG--------TTPKREASSGSGH 305
                          |:..:....::|..:.....|..:..:.|.        ||.||   ..:|.
Human   290 --------------GKAFNQFSNLTTHKKIHTGEQPYICEECGKAFTQSSTLTTHKR---IHTGE 337

  Fly   306 HPVKKRNSQQMTKCQKC----NGSGVVLVGQHSHASHSG--------VGGSVKQSVTVKTECLSC 358
            .|.         ||::|    |.|..:.  :|.:. |:|        .|.:..:|..: ||....
Human   338 KPY---------KCEECGKAFNRSSKLT--EHKNI-HTGEQPYKCEECGKAFNRSSNL-TEHRKI 389

  Fly   359 RNPSKPFSCNICGGLFSRYSSLWSHKKLHSGEKNYKCSICGLAFAKAVYLKNHARIHTGEKPYKC 423
            ....||:.|..||..|...|:|.:||::|:|||.|||..||.||.::..|..|.::|||:|||||
Human   390 HTEEKPYKCKECGKAFKHSSALTTHKRIHTGEKPYKCEECGKAFNRSSKLTEHKKLHTGKKPYKC 454

  Fly   424 QTCGMQFSQSPHLKNHERTHSGERPYVCGVCDKGFARHATLWNHRRIHTGEKPYKCEICGSAFSQ 488
            :.||..|.||..|..|::.||||.||.|..|.|.|...::|..|:||||||||||||.||.|||:
Human   455 EECGKAFIQSSKLTEHKKIHSGEIPYKCEECGKAFKHSSSLTTHKRIHTGEKPYKCEECGKAFSR 519

  Fly   489 AAHLKNHAKVHSGEKPYKCEICSAAFADRFALKRHRGIH 527
            ::.|..|..:|:||||||||.|..||.....|.:|:.||
Human   520 SSKLTEHKIIHTGEKPYKCERCDKAFNQSANLTKHKKIH 558

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Clamp	NP_001014498.1	COG5048	<359..498	CDD:227381	69/138 (50%)
		C2H2 Zn finger	367..387	CDD:275368	8/19 (42%)
		zf-H2C2_2	379..403	CDD:290200	13/23 (57%)
		C2H2 Zn finger	395..415	CDD:275368	7/19 (37%)
		zf-H2C2_2	407..432	CDD:290200	13/24 (54%)
		C2H2 Zn finger	423..443	CDD:275368	8/19 (42%)
		zf-H2C2_2	435..460	CDD:290200	12/24 (50%)
		C2H2 Zn finger	451..471	CDD:275368	7/19 (37%)
		zf-H2C2_2	464..488	CDD:290200	18/23 (78%)
		COG5048	475..>529	CDD:227381	29/53 (55%)
		C2H2 Zn finger	479..499	CDD:275368	9/19 (47%)
		zf-H2C2_2	491..515	CDD:290200	13/23 (57%)
		C2H2 Zn finger	507..527	CDD:275368	7/19 (37%)
ZNF675	NP_612203.2	KRAB	4..62	CDD:214630
		KRAB	4..43	CDD:279668
		COG5048	169..556	CDD:227381	136/442 (31%)
		C2H2 Zn finger	174..194	CDD:275370	7/19 (37%)
		C2H2 Zn finger	202..222	CDD:275368	4/31 (13%)
		C2H2 Zn finger	230..250	CDD:275368	1/19 (5%)
		C2H2 Zn finger	258..278	CDD:275368	5/19 (26%)
		zf-H2C2_2	270..295	CDD:290200	6/42 (14%)
		C2H2 Zn finger	286..306	CDD:275368	5/37 (14%)
		C2H2 Zn finger	314..334	CDD:275368	5/22 (23%)
		zf-H2C2_2	327..351	CDD:290200	9/35 (26%)
		C2H2 Zn finger	342..362	CDD:275368	5/22 (23%)
		C2H2 Zn finger	370..390	CDD:275368	4/20 (20%)
		zf-H2C2_2	382..407	CDD:290200	8/25 (32%)
		C2H2 Zn finger	398..418	CDD:275368	8/19 (42%)
		zf-H2C2_2	410..435	CDD:290200	14/24 (58%)
		C2H2 Zn finger	426..446	CDD:275368	7/19 (37%)
		C2H2 Zn finger	454..474	CDD:275368	8/19 (42%)
		C2H2 Zn finger	482..502	CDD:275368	7/19 (37%)
		zf-H2C2_2	494..519	CDD:290200	18/24 (75%)
		C2H2 Zn finger	510..530	CDD:275368	9/19 (47%)
		C2H2 Zn finger	538..558	CDD:275368	7/19 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910