DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Clamp and ZNF883

DIOPT Version :9

Sequence 1:	NP_001014498.1	Gene:	Clamp / 35445	FlyBaseID:	FBgn0032979	Length:	566	Species:	Drosophila melanogaster
Sequence 2:	NP_001094808.1	Gene:	ZNF883 / 169834	HGNCID:	27271	Length:	379	Species:	Homo sapiens

Alignment Length:	410	Identity:	121/410 - (29%)
Similarity:	162/410 - (39%)	Gaps:	116/410 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   127 FKCDVCSDMFPHLALLNAHKRMHTDGEQQQQQQHNAQAGGDSIAVVSAQGLVQAQNIIGNGQMGQ 191
            :.|..|...:..||.|..|::.|. ||    :.:..:..|.|....|  .|||.|.|    ..|:
Human    13 YLCTECGKGYTCLASLTQHQKTHI-GE----KPYECKICGKSFTRNS--NLVQHQRI----HTGE 66

  Fly   192 IQIVSSDTLEPVQQSVMQQQQHESKASKCINCGSSMLQ-------QSKRKGPKQVRCESCMQAEQ 249
                                    |..:|..||.:..|       |....|.|...|..|   |:
Human    67 ------------------------KPYECNECGKAFSQSTNLIQHQRVHTGEKPYECNEC---EK 104

  Fly   250 TAQQQQQLFVAQDGQMAHPVQIISTTPQAQAQLQQIVAAQTGGTTPKREASSGSGHHPVKKRNSQ 314
            |...:..|   ::.:..|                                 :|...:|
Human   105 TFSHRSSL---RNHERIH---------------------------------TGEKPYP------- 126

  Fly   315 QMTKCQKCNG--SGVVLVGQHSHASHSGVGGSVKQSVTVKTECLSCRNPSKPFSCNICGGLFSRY 377
                |.:|..  |.:..:.|| |..|:|                     .||:.|..||..|||.
Human   127 ----CNECGKAFSHISALTQH-HRIHTG---------------------KKPYECTECGKTFSRS 165

  Fly   378 SSLWSHKKLHSGEKNYKCSICGLAFAKAVYLKNHARIHTGEKPYKCQTCGMQFSQSPHLKNHERT 442
            :.|..|:.:||.||:|:|..|...|..:..|..|.|.|||||||:|..||..||.:|....|:|.
Human   166 THLIEHQGIHSEEKSYQCKQCRKVFCHSTSLIRHQRTHTGEKPYECNECGKAFSHTPAFIQHQRI 230

  Fly   443 HSGERPYVCGVCDKGFARHATLWNHRRIHTGEKPYKCEICGSAFSQAAHLKNHAKVHSGEKPYKC 507
            |:||:||.|..|.|.|.|.|.|..|:|.|||||||.|:.||..||::.||..|.|:||..|||:|
Human   231 HTGEKPYECNACGKAFNRSAHLTEHQRTHTGEKPYVCKECGKTFSRSTHLTEHLKIHSCVKPYQC 295

  Fly   508 EICSAAFADRFALKRHRGIH 527
            ..|...|..|.:|.||:..|
Human   296 NECQKLFCYRTSLIRHQRTH 315

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Clamp	NP_001014498.1	COG5048	<359..498	CDD:227381	65/138 (47%)
		C2H2 Zn finger	367..387	CDD:275368	8/19 (42%)
		zf-H2C2_2	379..403	CDD:290200	9/23 (39%)
		C2H2 Zn finger	395..415	CDD:275368	6/19 (32%)
		zf-H2C2_2	407..432	CDD:290200	14/24 (58%)
		C2H2 Zn finger	423..443	CDD:275368	8/19 (42%)
		zf-H2C2_2	435..460	CDD:290200	11/24 (46%)
		C2H2 Zn finger	451..471	CDD:275368	9/19 (47%)
		zf-H2C2_2	464..488	CDD:290200	14/23 (61%)
		COG5048	475..>529	CDD:227381	25/53 (47%)
		C2H2 Zn finger	479..499	CDD:275368	9/19 (47%)
		zf-H2C2_2	491..515	CDD:290200	11/23 (48%)
		C2H2 Zn finger	507..527	CDD:275368	7/19 (37%)
ZNF883	NP_001094808.1	COG5048	11..377	CDD:227381	121/410 (30%)
		C2H2 Zn finger	15..35	CDD:275368	6/19 (32%)
		zf-H2C2_2	27..52	CDD:290200	7/29 (24%)
		C2H2 Zn finger	43..63	CDD:275368	8/25 (32%)
		zf-H2C2_2	55..80	CDD:290200	10/52 (19%)
		C2H2 Zn finger	71..91	CDD:275368	5/19 (26%)
		zf-H2C2_2	83..108	CDD:290200	7/27 (26%)
		C2H2 Zn finger	99..119	CDD:275368	5/25 (20%)
		zf-H2C2_2	111..136	CDD:290200	6/71 (8%)
		C2H2 Zn finger	127..147	CDD:275368	6/20 (30%)
		zf-H2C2_2	139..164	CDD:290200	11/46 (24%)
		C2H2 Zn finger	155..175	CDD:275368	8/19 (42%)
		C2H2 Zn finger	183..203	CDD:275368	6/19 (32%)
		zf-H2C2_2	195..220	CDD:290200	14/24 (58%)
		C2H2 Zn finger	211..231	CDD:275368	8/19 (42%)
		C2H2 Zn finger	239..259	CDD:275368	9/19 (47%)
		zf-H2C2_2	251..276	CDD:290200	14/24 (58%)
		C2H2 Zn finger	267..287	CDD:275368	9/19 (47%)
		C2H2 Zn finger	295..315	CDD:275368	7/19 (37%)
		zf-H2C2_2	307..331	CDD:290200	4/9 (44%)
		C2H2 Zn finger	323..343	CDD:275368
		C2H2 Zn finger	351..371	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000