DRSC/TRiP Functional Genomics Resources

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Protein Alignment Clamp and ZNF610

DIOPT Version :9

Sequence 1:NP_001014498.1 Gene:Clamp / 35445 FlyBaseID:FBgn0032979 Length:566 Species:Drosophila melanogaster
Sequence 2:NP_001154897.1 Gene:ZNF610 / 162963 HGNCID:26687 Length:462 Species:Homo sapiens


Alignment Length:264 Identity:93/264 - (35%)
Similarity:128/264 - (48%) Gaps:60/264 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly   297 REASSGSGHHPVKKRNSQQMTKCQKCNGSGVVLVGQHSH-----ASHSGVGGSVKQSVTVKTECL 356
            |..:|.:.|..:  ..:::..||.:|   |.|. .::||     ..|:|                
Human   214 RVRASLTNHQVI--HTAEKPYKCTEC---GKVF-SRNSHLVEHWRIHTG---------------- 256

  Fly   357 SCRNPSKPFSCNICGGLFSRYSSLWSHKKLHSGEKNYKCSICGLAFAKAVYLKNHARIHTGEKPY 421
                 .||:.|:.|..:|:|.|:|..|:::|:|||.:||:.||.||.:...|..|..||||||||
Human   257 -----QKPYKCSECDKVFNRNSNLARHQRIHTGEKPHKCNECGKAFRECSGLTTHLVIHTGEKPY 316

  Fly   422 KCQTCGMQFSQSPHLKNHERTHSGERPYVCGVCDKGF------ARHATLWN-------------- 466
            ||..||..|.....|.||:|:|:.|:||.|..|.|.|      |||..:.:              
Human   317 KCNECGKNFRHKFSLTNHQRSHTAEKPYKCNECGKVFSLLSYLARHQIIHSTEKPYKCNECGRAF 381

  Fly   467 HRR--------IHTGEKPYKCEICGSAFSQAAHLKNHAKVHSGEKPYKCEICSAAFADRFALKRH 523
            |:|        ||||||||||..|...|.:..:|.||.::|:||:||||..|...|.....|.||
Human   382 HKRPGLMAHLLIHTGEKPYKCNECDKVFGRKLYLTNHQRIHTGERPYKCNACGKVFNQNPHLSRH 446

  Fly   524 RGIH 527
            |.||
Human   447 RKIH 450

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ClampNP_001014498.1 COG5048 <359..498 CDD:227381 66/166 (40%)
C2H2 Zn finger 367..387 CDD:275368 7/19 (37%)
zf-H2C2_2 379..403 CDD:290200 11/23 (48%)
C2H2 Zn finger 395..415 CDD:275368 7/19 (37%)
zf-H2C2_2 407..432 CDD:290200 15/24 (63%)
C2H2 Zn finger 423..443 CDD:275368 8/19 (42%)
zf-H2C2_2 435..460 CDD:290200 12/30 (40%)
C2H2 Zn finger 451..471 CDD:275368 9/47 (19%)
zf-H2C2_2 464..488 CDD:290200 14/45 (31%)
COG5048 475..>529 CDD:227381 25/53 (47%)
C2H2 Zn finger 479..499 CDD:275368 6/19 (32%)
zf-H2C2_2 491..515 CDD:290200 11/23 (48%)
C2H2 Zn finger 507..527 CDD:275368 7/19 (37%)
ZNF610NP_001154897.1 KRAB 24..82 CDD:214630
KRAB 24..63 CDD:279668
C2H2 Zn finger 206..226 CDD:275368 3/13 (23%)
COG5048 217..>291 CDD:227381 25/100 (25%)
zf-H2C2_2 218..243 CDD:290200 7/30 (23%)
C2H2 Zn finger 234..254 CDD:275368 6/23 (26%)
zf-H2C2_2 246..271 CDD:290200 8/45 (18%)
COG5048 <257..446 CDD:227381 76/188 (40%)
zf-C2H2 260..282 CDD:278523 7/21 (33%)
C2H2 Zn finger 262..282 CDD:275368 7/19 (37%)
zf-H2C2_2 274..297 CDD:290200 10/22 (45%)
C2H2 Zn finger 290..310 CDD:275368 7/19 (37%)
zf-H2C2_2 303..327 CDD:290200 15/23 (65%)
zf-C2H2 316..338 CDD:278523 10/21 (48%)
C2H2 Zn finger 318..338 CDD:275368 8/19 (42%)
zf-H2C2_2 330..354 CDD:290200 11/23 (48%)
C2H2 Zn finger 346..366 CDD:275368 7/19 (37%)
zf-H2C2_2 358..382 CDD:290200 3/23 (13%)
C2H2 Zn finger 374..394 CDD:275368 2/19 (11%)
zf-H2C2_2 387..411 CDD:290200 12/23 (52%)
C2H2 Zn finger 402..422 CDD:275368 6/19 (32%)
zf-H2C2_2 414..439 CDD:290200 12/24 (50%)
C2H2 Zn finger 430..450 CDD:275368 7/19 (37%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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