Protein Alignment Clamp and ZNF558

DIOPT Version :10

• Sequence 1: NP_001014498.1
• Gene: Clamp / 35445
• FlyBaseID: FBgn0032979
• Length: 566
• Species: Drosophila melanogaster
• Sequence 2: NP_653294.1
• Gene: ZNF558 / 148156
• HGNCID: 26422
• Length: 402
• Species: Homo sapiens
• Alignment Length: 447
• Identity: 128/447 - (28%)
• Similarity: 197/447 - (44%)
• Gaps: 107/447 - (23%)

  Fly   133 SDMFPHLALLNAHKRMHTDGEQQQQQQHNAQAGGDSIAVVSA---QGLVQAQNIIGNGQMGQIQI 194
            |.:||                ..||:.|.  .||:.:..:..   :|||..:::       .::.
Human    13 SSLFP----------------ASQQKGHT--QGGELVNELLTSWLRGLVTFEDV-------AVEF 52

  Fly   195 VSSD--TLEPVQQSVMQQQQHESKASKCINCGSSMLQQSKRKGPKQVRCESCMQAEQTAQQQQQL 257
            ...:  .|:|.|:::.:....|:    |.|..|...:.:|.....|:            :|.:::
Human    53 TQEEWALLDPAQRTLYRDVMLEN----CRNLASLGCRVNKPSLISQL------------EQDKKV 101

  Fly   258 FVAQDGQMAHPVQIISTTPQAQAQLQQIVAAQTGGTTPK-----REASSGSGHHPVKKRNSQQMT 317
            ...:.|.:.      ||.|    .|:.::.|:  ..|||     :|.|.|     ||...|.:..
Human   102 VTEERGILP------STCP----DLETLLKAK--WLTPKKNVFRKEQSKG-----VKTERSHRGV 149

  Fly   318 KCQKCNGSGVVL-----VGQHSH---------ASHSGVGGSVKQSVTVKT---------ECLSC- 358
            |..:||....|.     :.||..         .|..|...|.:..:|:..         ||..|
Human   150 KLNECNQCFKVFSTKSNLTQHKRIHTGEKPYDCSQCGKSFSSRSYLTIHKRIHNGEKPYECNHCG 214

  Fly   359 ---RNPS------------KPFSCNICGGLFSRYSSLWSHKKLHSGEKNYKCSICGLAFAKAVYL 408
               .:||            ||:.||.|..:|....:|.|||::|:||.:::|:.||.||:....|
Human   215 KAFSDPSSLRLHLRIHTGEKPYECNQCFHVFRTSCNLKSHKRIHTGENHHECNQCGKAFSTRSSL 279

  Fly   409 KNHARIHTGEKPYKCQTCGMQFSQSPHLKNHERTHSGERPYVCGVCDKGFARHATLWNHRRIHTG 473
            ..|..||||||||:|..||..|.:|.:|..|.|||:||:||.|..|.|.|:...:|..|:|||||
Human   280 TGHNSIHTGEKPYECHDCGKTFRKSSYLTQHVRTHTGEKPYECNECGKSFSSSFSLTVHKRIHTG 344

  Fly   474 EKPYKCEICGSAFSQAAHLKNHAKVHSGEKPYKCEICSAAFADRFALKRHRGIHQKY 530
            ||||:|..||.||:..:.:|.|.:.|:|||||:|..|..:|.....|..|:.||.::
Human   345 EKPYECSDCGKAFNNLSAVKKHLRTHTGEKPYECNHCGKSFTSNSYLSVHKRIHNRW 401

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Clamp	NP_001014498.1	COG5048	<359..498	CDD:227381	66/150 (44%)
		C2H2 Zn finger	367..387	CDD:275368	8/19 (42%)
		C2H2 Zn finger	395..415	CDD:275368	7/19 (37%)
		zf-H2C2_2	407..432	CDD:463886	14/24 (58%)
		C2H2 Zn finger	423..443	CDD:275368	8/19 (42%)
		C2H2 Zn finger	451..471	CDD:275368	7/19 (37%)
		COG5048	475..>529	CDD:227381	23/53 (43%)
		C2H2 Zn finger	479..499	CDD:275368	7/19 (37%)
		C2H2 Zn finger	507..527	CDD:275368	5/19 (26%)
ZNF558	NP_653294.1	KRAB	43..100	CDD:214630	11/79 (14%)
		C2H2 Zn finger	154..174	CDD:275368	5/19 (26%)
		COG5048	<162..398	CDD:227381	86/235 (37%)
		C2H2 Zn finger	182..202	CDD:275368	4/19 (21%)
		C2H2 Zn finger	210..230	CDD:275368	4/19 (21%)
		C2H2 Zn finger	238..258	CDD:275368	8/19 (42%)
		C2H2 Zn finger	266..286	CDD:275368	7/19 (37%)
		C2H2 Zn finger	294..314	CDD:275368	8/19 (42%)
		C2H2 Zn finger	322..342	CDD:275368	7/19 (37%)
		C2H2 Zn finger	350..370	CDD:275368	7/19 (37%)
		C2H2 Zn finger	378..398	CDD:275368	5/19 (26%)