Protein Alignment Clamp and ZNF560

DIOPT Version :10

• Sequence 1: NP_001014498.1
• Gene: Clamp / 35445
• FlyBaseID: FBgn0032979
• Length: 566
• Species: Drosophila melanogaster
• Sequence 2: NP_689689.2
• Gene: ZNF560 / 147741
• HGNCID: 26484
• Length: 790
• Species: Homo sapiens
• Alignment Length: 378
• Identity: 75/378 - (19%)
• Similarity: 137/378 - (36%)
• Gaps: 112/378 - (29%)

  Fly   219 MDEA------LSFTRNHLESLTSGNASTASPHLLKHIQNSLYIPRYCNIEVLVAREYISYYEQEE 277
            ||||      |..|.:...||||.||.:.      .|::.......|.|| ..|.|    :|.|.
Human   352 MDEADSVFLKLKQTADDSLSLTSSNAESV------FIEDPYIASLRCEIE-SDAHE----FEAES 405

  Fly   278 GHDEILLKFAK-----------LNFNFCQ--FHYVQELKTLTKWWRDLDLASKLPYIRDRLVESH 329
            ....:.|.:||           :.:...|  .|:|:.||.:.|             :..|.::..
Human   406 WSLSVDLAYAKKQKKEVVKRQDVLYELMQTEAHHVRTLKIMLK-------------VYSRALQEE 457

  Fly   330 LVALGPYFEPHYSLGRIIVAKINMIMVVVDDTYDAYATLPQVKALTECLQRWSIEVSDKLPDYLR 394
            |...|              ..::.:....||..|.::..  :..|.|..|.:..|.||:     .
Human   458 LQFSG--------------QAVSRLFPCADDLLDMHSHF--LARLKERRQEFLEEGSDR-----N 501

  Fly   395 IVLGSLFDVM-----GEIEREMRPLGRLYRV-----KQVVEKIKII---TKAYQEIAKWARTGHV 446
            .|:..:.||:     ||....|:   ..|.|     ...|.:.|::   :|.:|.:.|     .:
Human   502 YVIQKIGDVLVQQFSGETGERMK---EKYAVFCSGHNDAVGQYKLLLQQSKKFQNLIK-----KI 558

  Fly   447 STFDEYMKVGV------LTAGMADYAAYCFIGMEDINEK-----EAFEWLNSNPLIIKHLTAMFR 500
            ..|....::||      :|..:..|.    :.:|.|.:.     |.::.|:....:||.:.:  :
Human   559 GNFSIVRRLGVQECILLVTQRITKYP----VLVERIIQNTEAGTEDYKDLSQALSLIKDIIS--Q 617

  Fly   501 LANDVGTYETEINRGEVANGLNCYMKQYGVTKEEASRELRKMYVYRKKVVVEE 553
            :...|..||.:....|:|          ..|.:::|.:|:....:||:.::::
Human   618 VDAKVSEYEKDQRLKEIA----------AKTDQKSSGKLKNGLTFRKEDMLQQ 660

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Clamp	NP_001014498.1	COG5048	<359..498	CDD:227381	33/162 (20%)
		C2H2 Zn finger	367..387	CDD:275368	4/19 (21%)
		C2H2 Zn finger	395..415	CDD:275368	6/24 (25%)
		zf-H2C2_2	407..432	CDD:463886	5/32 (16%)
		C2H2 Zn finger	423..443	CDD:275368	5/22 (23%)
		C2H2 Zn finger	451..471	CDD:275368	4/25 (16%)
		COG5048	475..>529	CDD:227381	10/58 (17%)
		C2H2 Zn finger	479..499	CDD:275368	4/24 (17%)
		C2H2 Zn finger	507..527	CDD:275368	4/19 (21%)
ZNF560	NP_689689.2	KRAB	13..69	CDD:214630
		KRAB	110..161	CDD:214630
		C2H2 Zn finger	294..314	CDD:275368
		C2H2 Zn finger	323..342	CDD:275368
		COG5048	344..754	CDD:227381	75/378 (20%)
		C2H2 Zn finger	350..370	CDD:275368	6/17 (35%)
		C2H2 Zn finger	378..398	CDD:275368	4/26 (15%)
		C2H2 Zn finger	406..426	CDD:275368	3/19 (16%)
		C2H2 Zn finger	434..454	CDD:275368	7/32 (22%)
		C2H2 Zn finger	490..510	CDD:275368	5/24 (21%)
		C2H2 Zn finger	518..538	CDD:275368	4/22 (18%)
		C2H2 Zn finger	546..566	CDD:275368	4/24 (17%)
		C2H2 Zn finger	574..594	CDD:275368	4/23 (17%)
		C2H2 Zn finger	602..622	CDD:275368	3/21 (14%)
		C2H2 Zn finger	630..650	CDD:275368	5/29 (17%)
		C2H2 Zn finger	658..678	CDD:275368	0/3 (0%)
		C2H2 Zn finger	714..734	CDD:275368
		C2H2 Zn finger	742..762	CDD:275368
		zf-H2C2_2	757..779	CDD:463886
		C2H2 Zn finger	770..790	CDD:275368