DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Clamp and IKZF1

DIOPT Version :9

Sequence 1:	NP_001014498.1	Gene:	Clamp / 35445	FlyBaseID:	FBgn0032979	Length:	566	Species:	Drosophila melanogaster
Sequence 2:	XP_011513360.1	Gene:	IKZF1 / 10320	HGNCID:	13176	Length:	563	Species:	Homo sapiens

Alignment Length:	358	Identity:	82/358 - (22%)
Similarity:	145/358 - (40%)	Gaps:	47/358 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   224 GSSMLQQSKRKGPKQVRCESCMQAEQTAQQQQQLFVAQDGQMAHPVQIISTTPQAQ--AQLQQIV 286
            |..|.|.|.::.|..  .::..:.::.....:.|.....||.:.....:..|..|.  .....|:
Human    30 GQDMSQVSGKESPPV--SDTPDEGDEPMPIPEDLSTTSGGQQSSKSDRVVVTYGADDFRDFHAII 92

  Fly   287 AAQTGGTTPKREASSGSGHHPVKKRNSQQMTK-CQKCNGSGVVLVGQH---SHASHSGVGGSVKQ 347
            ......:..|.|..|...:....:.|.::..: .:..:.||..:.|.|   ..::.|||||
Human    93 PKSFSPSNVKVETQSDEENGRACEMNGEECAEDLRMLDASGEKMNGSHRDQGSSALSGVGG---- 153

  Fly   348 SVTVKTECLSCRNPSKPFSCNICGGLFSRYSSLWSHKKLHSGEKNYKCSICGLAFAKAVYLKNHA 412
                      .|.|:....|:|||.:....:.|..||:.|:||:.::|:.||.:|.:...|..|.
Human   154 ----------IRLPNGKLKCDICGIICIGPNVLMVHKRSHTGERPFQCNQCGASFTQKGNLLRHI 208

  Fly   413 RIHTGEKPYKCQTCGMQFSQSPHLKNHERTHSGERPYVCGVCDKGFARHATLWNHRRIHTGEKPY 477
            ::|:||||:||..|.....:...|..|.||||..:|:.||.|.:.:.:.::|..|:.
Human   209 KLHSGEKPFKCHLCNYACRRRDALTGHLRTHSVGKPHKCGYCGRSYKQRSSLEEHKE-------- 265

  Fly   478 KCE-------ICGSAFSQAAHLKNHAKVHSGEKPYKCEICS--AAFADRFA---LKRHRGIHQKY 530
            :|.       :.|:.:.......||:::...    .|:|.|  :...||.|   .||...:.||:
Human   266 RCHNYLESMGLPGTLYPVIKEETNHSEMAED----LCKIGSERSLVLDRLASNVAKRKSSMPQKF 326

  Fly   531 -GQTAPRQTSSDGMIVHKQEIPDMEDEAQQEVI 562
             |......|..|....:::|...|:.....:.|
Human   327 LGDKGLSDTPYDSSASYEKENEMMKSHVMDQAI 359

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Clamp	NP_001014498.1	COG5048	<359..498	CDD:227381	42/145 (29%)
		C2H2 Zn finger	367..387	CDD:275368	7/19 (37%)
		zf-H2C2_2	379..403	CDD:290200	9/23 (39%)
		C2H2 Zn finger	395..415	CDD:275368	6/19 (32%)
		zf-H2C2_2	407..432	CDD:290200	10/24 (42%)
		C2H2 Zn finger	423..443	CDD:275368	5/19 (26%)
		zf-H2C2_2	435..460	CDD:290200	10/24 (42%)
		C2H2 Zn finger	451..471	CDD:275368	5/19 (26%)
		zf-H2C2_2	464..488	CDD:290200	4/30 (13%)
		COG5048	475..>529	CDD:227381	12/65 (18%)
		C2H2 Zn finger	479..499	CDD:275368	4/26 (15%)
		zf-H2C2_2	491..515	CDD:290200	5/25 (20%)
		C2H2 Zn finger	507..527	CDD:275368	8/24 (33%)
IKZF1	XP_011513360.1	C2H2 Zn finger	163..183	CDD:275368	7/19 (37%)
		zf-H2C2_2	176..200	CDD:372612	10/23 (43%)
		COG5048	187..>343	CDD:227381	43/167 (26%)
		C2H2 Zn finger	191..211	CDD:275368	6/19 (32%)
		zf-H2C2_2	203..228	CDD:372612	10/24 (42%)
		C2H2 Zn finger	219..239	CDD:275368	5/19 (26%)
		C2H2 Zn finger	247..268	CDD:275368	5/28 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910