DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Clamp and Ikzf4

DIOPT Version :9

Sequence 1:	NP_001014498.1	Gene:	Clamp / 35445	FlyBaseID:	FBgn0032979	Length:	566	Species:	Drosophila melanogaster
Sequence 2:	XP_006240794.1	Gene:	Ikzf4 / 100361923	RGDID:	2319157	Length:	586	Species:	Rattus norvegicus

Alignment Length:	335	Identity:	85/335 - (25%)
Similarity:	119/335 - (35%)	Gaps:	104/335 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   276 PQAQAQ----LQQIVAAQTGGTTPKREASSGSGHHPVKKRNSQQMTKCQKCNGSGVVLVGQHSHA 336
            ||||..    ::.:....:|.::.::|.........|...||                  |||..
  Rat    44 PQAQDSNHFIMESLFCESSGDSSLEKEFLGAPVGPSVSTPNS------------------QHSSP 90

  Fly   337 SHSGVGGSVKQSVTVKTECLSCRNP-----------------SKPFSCNICGGLFSRYSSLWSHK 384
            |.|....|:|..:....|......|                 |:|.  ..|.|     |....|.
  Rat    91 SRSLSANSIKVEMYSDEESSRLLGPDERLLDKDDSVIVEDSLSEPL--GYCDG-----SGPEPHS 148

  Fly   385 ----KLHSGEKNYKCSICGLAFAKAVYLKNHARIHTGEKPYKCQTCGMQFSQSPHLKNHERTHSG 445
                :|.:|:  .||.:||:.......|..|.|.||||:|:.|..||..|:|..:|..|.:.|||
  Rat   149 PGGIRLPNGK--LKCDVCGMVCIGPNVLMVHKRSHTGERPFHCNQCGASFTQKGNLLRHIKLHSG 211

  Fly   446 ERPYVCGVCDKGFARHATLWNHRRIH-----TGEKPYKCEICGSAFSQAAHLKNH---------- 495
            |:|:.|..|:....|...|..|.|.|     |..|||||..||.::.|.:.|:.|
  Rat   212 EKPFKCPFCNYACRRRDALTGHLRTHSVSSPTVGKPYKCNYCGRSYKQQSTLEEHKERCHNYLQS 276

  Fly   496 ------------------------AKVH-SGEKPYKCEICSAAFADRFA---LKRHRGIHQKY-G 531
                                    :.:| |.|:|        .|.||.|   .||.|...||: |
  Rat   277 LSTDAQTLAGQPGDEIRDLEMVPDSMLHPSTERP--------TFIDRLANSLTKRKRSTPQKFVG 333

  Fly   532 QTAPRQTSSD 541
            :...|.:.||
  Rat   334 EKQMRFSLSD 343

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Clamp	NP_001014498.1	COG5048	<359..498	CDD:227381	51/198 (26%)
		C2H2 Zn finger	367..387	CDD:275368	4/23 (17%)
		zf-H2C2_2	379..403	CDD:290200	7/27 (26%)
		C2H2 Zn finger	395..415	CDD:275368	6/19 (32%)
		zf-H2C2_2	407..432	CDD:290200	12/24 (50%)
		C2H2 Zn finger	423..443	CDD:275368	7/19 (37%)
		zf-H2C2_2	435..460	CDD:290200	9/24 (38%)
		C2H2 Zn finger	451..471	CDD:275368	6/19 (32%)
		zf-H2C2_2	464..488	CDD:290200	12/28 (43%)
		COG5048	475..>529	CDD:227381	21/91 (23%)
		C2H2 Zn finger	479..499	CDD:275368	6/53 (11%)
		zf-H2C2_2	491..515	CDD:290200	6/58 (10%)
		C2H2 Zn finger	507..527	CDD:275368	7/22 (32%)
Ikzf4	XP_006240794.1	C2H2 Zn finger	161..181	CDD:275368	6/19 (32%)
		zf-H2C2_2	174..198	CDD:404364	12/23 (52%)
		C2H2 Zn finger	189..209	CDD:275368	7/19 (37%)
		zf-H2C2_2	201..226	CDD:404364	9/24 (38%)
		SFP1	<211..271	CDD:227516	21/59 (36%)
		C2H2 Zn finger	217..237	CDD:275368	6/19 (32%)
		C2H2 Zn finger	250..271	CDD:275368	6/20 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910