DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Clamp and si:ch211-222k6.1

DIOPT Version :9

Sequence 1:	NP_001014498.1	Gene:	Clamp / 35445	FlyBaseID:	FBgn0032979	Length:	566	Species:	Drosophila melanogaster
Sequence 2:	XP_021324960.1	Gene:	si:ch211-222k6.1 / 100034531	ZFINID:	ZDB-GENE-050208-649	Length:	674	Species:	Danio rerio

Alignment Length:	516	Identity:	131/516 - (25%)
Similarity:	190/516 - (36%)	Gaps:	134/516 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   101 TVDAQGRIQIVNQ--NKPIAANTISNISFKCDVCSDMFPHLALLNAHKRMHTDGEQQQQQQHNAQ 163
            |.|..|:..::.:  ||.:..:| ....|.||.|...|.|...|..|.::|| ||    :.|...
Zfish   115 TCDQCGKSFLLKERLNKHLKIHT-GEKPFTCDQCGKNFLHKGYLTEHIKIHT-GE----KPHTCD 173

  Fly   164 AGGDSIAVVSAQGLVQAQNIIGNGQM---------------GQIQIVSSDTLEPVQQSVMQQQQH 213
            ..|...|.   :|.:.....:..|:.               ..|:.|...|.|
Zfish   174 QCGKRFAY---KGNLTDHMKVHTGERPYACDQCAKRFKHKGNLIEHVKIHTGE------------ 223

  Fly   214 ESKASKCINCGSS-----MLQQSKR--KGPKQVRCESCMQAEQTAQQQQQLFVAQDGQMAHPVQI 271
              :...|..||..     :|....|  .|.|...||.|.::....:.......:..|...|
Zfish   224 --RPYSCDQCGKKFKLKHILSDHMRIHTGEKPFTCEKCGRSYTRKRNLSDHMKSHTGVKLH---- 282

  Fly   272 ISTTPQAQAQLQQIVAAQTGGTTPKREASSGSGHHPVKKRNSQQMTKCQKCNGS----GVVLVGQ 332
                          ...|.|    |....:|.....::..:.::...|.:|...    |.:.|.|
Zfish   283 --------------TCDQCG----KSFVKTGVFKVHLRTHSRERPFNCDQCGKDFLRMGTLKVHQ 329

  Fly   333 HSHASHSGVGGSVKQSVTVKTECLSCRNPSKPFSCNICGGLFSRYSSLWSHKKLHSGEKNYKCSI 397
               ..|||:                     |...|:.||..|.|.|.|..|:.:|:|||.:|||.
Zfish   330 ---KRHSGI---------------------KDHICSECGKTFFRDSELKVHQSVHTGEKPFKCSH 370

  Fly   398 CGLAFAKAVYLKNHARIHTGEKPYKCQTCGMQFSQ----SPHLKNHER----------------- 441
            |...|.:|.|:|.|.:||||||||:|:.||.:|..    :.|:|||.|
Zfish   371 CEKTFKRAEYMKMHRKIHTGEKPYECEKCGKKFRHKGNFNDHVKNHTRIKPFSCDQCGKCFRLKD 435

  Fly   442 -------THSGERPYVCGVCDKGFARHATLWNHRRIHTGEKPYKCEICGSAFSQAAHLKNHAKVH 499
                   .|:|..|:.|..|.|.|.:...|..|..|||||||:.||.||::|::..:|.:|..:|
Zfish   436 NFDDHMKVHTGGNPHTCAQCGKTFKQKHVLNEHLIIHTGEKPFTCEQCGTSFTRKRNLADHMTIH 500

  Fly   500 SGEKPYKCEICSAAFADRFALKRHRGIHQ-----KYGQTAPRQTSSDG----MIVHKQEIP 551
            :||..|.|:.|..:|.....||.|...|.     ...|...:...:|.    :.||.||.|
Zfish   501 TGENLYACDQCGRSFRQSRVLKEHLRTHSSERPFNCDQCGKKFFKADALKEHLTVHTQEKP 561

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Clamp	NP_001014498.1	COG5048	<359..498	CDD:227381	62/166 (37%)
		C2H2 Zn finger	367..387	CDD:275368	8/19 (42%)
		zf-H2C2_2	379..403	CDD:290200	10/23 (43%)
		C2H2 Zn finger	395..415	CDD:275368	8/19 (42%)
		zf-H2C2_2	407..432	CDD:290200	15/24 (63%)
		C2H2 Zn finger	423..443	CDD:275368	9/47 (19%)
		zf-H2C2_2	435..460	CDD:290200	12/48 (25%)
		C2H2 Zn finger	451..471	CDD:275368	6/19 (32%)
		zf-H2C2_2	464..488	CDD:290200	14/23 (61%)
		COG5048	475..>529	CDD:227381	20/58 (34%)
		C2H2 Zn finger	479..499	CDD:275368	7/19 (37%)
		zf-H2C2_2	491..515	CDD:290200	8/23 (35%)
		C2H2 Zn finger	507..527	CDD:275368	6/19 (32%)
si:ch211-222k6.1	XP_021324960.1	C2H2 Zn finger	60..80	CDD:275368
		C2H2 Zn finger	88..108	CDD:275368
		C2H2 Zn finger	116..136	CDD:275368	4/19 (21%)
		C2H2 Zn finger	144..164	CDD:275368	7/19 (37%)
		zf-H2C2_2	156..181	CDD:316026	8/29 (28%)
		C2H2 Zn finger	172..192	CDD:275368	3/22 (14%)
		COG5048	196..607	CDD:227381	108/426 (25%)
		C2H2 Zn finger	200..220	CDD:275368	2/19 (11%)
		C2H2 Zn finger	228..248	CDD:275368	5/19 (26%)
		C2H2 Zn finger	256..276	CDD:275368	3/19 (16%)
		C2H2 Zn finger	284..304	CDD:275368	4/23 (17%)
		C2H2 Zn finger	312..332	CDD:275368	5/22 (23%)
		C2H2 Zn finger	340..360	CDD:275368	8/19 (42%)
		C2H2 Zn finger	368..388	CDD:275368	8/19 (42%)
		C2H2 Zn finger	396..416	CDD:275368	6/19 (32%)
		C2H2 Zn finger	424..444	CDD:275368	0/19 (0%)
		C2H2 Zn finger	452..472	CDD:275368	6/19 (32%)
		C2H2 Zn finger	480..500	CDD:275368	7/19 (37%)
		C2H2 Zn finger	508..528	CDD:275368	6/19 (32%)
		C2H2 Zn finger	536..556	CDD:275368	2/19 (11%)
		C2H2 Zn finger	564..584	CDD:275368
		C2H2 Zn finger	592..612	CDD:275368
		C2H2 Zn finger	620..640	CDD:275368
		C2H2 Zn finger	648..666	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24381
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.100