DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Clamp and znf865

DIOPT Version :9

Sequence 1:	NP_001014498.1	Gene:	Clamp / 35445	FlyBaseID:	FBgn0032979	Length:	566	Species:	Drosophila melanogaster
Sequence 2:	NP_001076544.1	Gene:	znf865 / 100034513	ZFINID:	ZDB-GENE-060503-896	Length:	1506	Species:	Danio rerio

Alignment Length:	922	Identity:	162/922 - (17%)
Similarity:	244/922 - (26%)	Gaps:	444/922 - (48%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 GTILKQPKIEGQKTEQQPTFYYTTNGN--GGTVNLAQL--ATTDDNK-----TCYIAQPVGGYNY 83
            |..:.||......:...|:...||:.|  ..:.::|.|  |.:|...     :|.:|.     |.
Zfish   181 GLSVPQPSPGPSSSSPSPSSSTTTSNNPPSSSSSVAGLVGAQSDARSLHQQFSCMLAA-----NQ 240

  Fly    84 ALVNGMPLNQGAALGIATVDAQGRIQIVNQNKPIAANTISNISFKCDVCSDMFPHLALLNAHKRM 148
            .|.:|:|.|......:........:.:.:.|..:|                  |..||..:|...
Zfish   241 YLFSGVPTNASLEQFLVQQGPHNHLGLADSNTGLA------------------PPPALHPSHTHG 287

  Fly   149 HTDGEQQQQQQ--------------------HNAQAGGDSIAVVSAQGLVQAQNIIGNGQMGQIQ 193
            |...:.|||||                    |.|                ...:.:|......|.
Zfish   288 HPTPQPQQQQQQLPPHALSHPHSHAHPHHPLHPA----------------PQPSPLGGFDFQGIP 336

  Fly   194 IVSSDTLEPVQQSVMQQQ--------------QHESKASKCINCGSSMLQQSKRKG------PKQ 238
            ::||:.|    .|:|||:              :.:.|.......|.|....|:||.      |::
Zfish   337 VLSSNQL----ASLMQQEAGLPLPLPLHLSVPKDDGKGDSGSGAGGSGGSGSRRKKAMAGYLPQR 397

  Fly   239 VRCESCMQAEQTAQQQQQLFVAQDGQM---------------AHPVQII-STTPQAQAQLQQIVA 287
            ....|...:..:|..........||..               ..|..|: |:||.:.:   ..|:
Zfish   398 KTDGSSSNSTSSANCHGSGAHGHDGSSGLVGGGGGVGMRGLGGDPSSILSSSTPSSSS---STVS 459

  Fly   288 AQTGGTTPKREAS---SGSGHHPVKKRNSQQMT---------------KCQK------------- 321
            :.:........||   |....:| |..|.|.||               :|.|
Zfish   460 SSSSSAPSSNSASVLVSNISQNP-KPENQQSMTPNITQTEQEALFHCGECGKSFGHLPTLRRHIR 523

  Fly   322 CNGSGVVLVGQHS-------------HASHSGVGGSVKQSVTVKTECLSCRNPSKPFSCNICGGL 373
            |:..|   .||:|             |::..|:..:............:|.:|.|.:.||.||..
Zfish   524 CHEDG---GGQNSSTNTNHQHQSDLPHSTQDGISQNAHHHENPDPMSSTCSSPDKSYCCNECGKG 585

  Fly   374 FSRYSSLWSHKKLHSGEKNYKCSICGLAFAKAVYLKNHARIHTGEKPYKCQTCGMQFSQSPHLKN 438
            |.:...|..|..:|||::.|.|::|..:|.:...|..|.:||. ||||:|..||..|.:|..|.|
Zfish   586 FKKRGHLLQHGVIHSGDRPYACTVCERSFNRRESLTRHEKIHE-EKPYRCPACGRCFRESTSLLN 649

  Fly   439 H---------------------------------------------------------------- 439
            |
Zfish   650 HAASGNCGKPGRRSRSSDGSSIGSVDGKVETDFPGGQITDTKDLVFCKNEDSTAGMSCDSLYSQA 714

  Fly   440 ----------------------------------------------------------------- 439

Zfish   715 RNANQNPIGKPKEEYNPEYSRDPYQTSYRVDDYRRQQGNPASYSGDSCSNSMSSPALRKAPLAPT 779

  Fly   440 ------ERTH------------------------------------------------------- 443
                  .:||
Zfish   780 LHPHPQNQTHHHQPQSHLPLSSLLDDSEDEVTSSAMSAIAAAAAASVLPAEMNNNGGREERRDII 844

  Fly   444 -----------------------------SG---------------------------------- 445
                                         ||
Zfish   845 GGLLGGLGFGSMGASSSTSAGNGGNEECLSGSMIPLSHPTQQQPNSQNANNPNAKPKRPRKPRQK 909

  Fly   446 ----------------------------ERPYVCGVCDKGFARHATLWNHRRIHTGEKPYKCEIC 482
                                        :|||:|.||.:||:|..||..|.|:||||||:.|:||
Zfish   910 REPRPPGAPGEVVKRRRSSQGGAAGDGSDRPYLCTVCGRGFSRRETLRRHERVHTGEKPFHCDIC 974

  Fly   483 GSAFSQAAHLKNHAKVHSGEKPYKCEICSAAFADRFALKRHRGIHQKYGQTAPRQTSSDGMIVHK 547
            |..|.:..||..|..||||||.|||.:|...|....:||||..:|.: |...||::.:..  ...
Zfish   975 GKDFREPFHLTKHQTVHSGEKNYKCTLCGKDFGYAQSLKRHEKLHLR-GDFKPRRSKTKS--AAN 1036

  Fly   548 QEIPDMEDEAQQ 559
            |.:|..:::..|
Zfish  1037 QGVPANQEQTDQ 1048

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Clamp	NP_001014498.1	COG5048	<359..498	CDD:227381	63/419 (15%)
		C2H2 Zn finger	367..387	CDD:275368	7/19 (37%)
		zf-H2C2_2	379..403	CDD:290200	8/23 (35%)
		C2H2 Zn finger	395..415	CDD:275368	5/19 (26%)
		zf-H2C2_2	407..432	CDD:290200	12/24 (50%)
		C2H2 Zn finger	423..443	CDD:275368	8/154 (5%)
		zf-H2C2_2	435..460	CDD:290200	15/305 (5%)
		C2H2 Zn finger	451..471	CDD:275368	10/19 (53%)
		zf-H2C2_2	464..488	CDD:290200	14/23 (61%)
		COG5048	475..>529	CDD:227381	26/53 (49%)
		C2H2 Zn finger	479..499	CDD:275368	8/19 (42%)
		zf-H2C2_2	491..515	CDD:290200	13/23 (57%)
		C2H2 Zn finger	507..527	CDD:275368	7/19 (37%)
znf865	NP_001076544.1	C2H2 Zn finger	505..525	CDD:275368	2/19 (11%)
		C2H2 Zn finger	579..599	CDD:275368	7/19 (37%)
		C2H2 Zn finger	607..627	CDD:275368	5/19 (26%)
		C2H2 Zn finger	634..650	CDD:275368	6/15 (40%)
		C2H2 Zn finger	943..963	CDD:275368	10/19 (53%)
		zf-H2C2_2	956..978	CDD:290200	13/21 (62%)
		C2H2 Zn finger	971..991	CDD:275368	8/19 (42%)
		zf-H2C2_2	983..1008	CDD:290200	14/24 (58%)
		C2H2 Zn finger	999..1019	CDD:275368	7/19 (37%)
		C2H2 Zn finger	1086..1109	CDD:275368
		C2H2 Zn finger	1117..1135	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910