DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42748 and AJM1

DIOPT Version :9

Sequence 1:	NP_001260684.1	Gene:	CG42748 / 35442	FlyBaseID:	FBgn0261802	Length:	2190	Species:	Drosophila melanogaster
Sequence 2:	NP_001073951.2	Gene:	AJM1 / 389813	HGNCID:	37284	Length:	976	Species:	Homo sapiens

Alignment Length:	1301	Identity:	278/1301 - (21%)
Similarity:	402/1301 - (30%)	Gaps:	451/1301 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   972 TTLEPEPALSSTVSLKPCAVANSSCREETPSDAINEPAS-------ATARPLSLPILSEP-PTNR 1028
            |..:|...|.|||        ....:..||.     |||       :.|||      :|| |.|:
Human     2 TRTDPPDLLVSTV--------YQDIKVATPG-----PASKCSPCERSVARP------AEPAPFNK 47

  Fly  1029 AHRILYSSQQLRRYE-------PKASPINKMPPANELSPQAAAVARTDEKHPTSRSLFSRFTHGL 1086
            .|        .|.::       |....:.:.||.....|:    |||.|..|
Human    48 RH--------CRSFDFLEALDGPAMETLPEPPPPESAVPR----ARTREAEP------------- 87

  Fly  1087 RFSLRRKKKQQQQEPSQVKESPKELRQSPEESQPVDFVHIPLKPPRSSQCGRLDDTIVSETSSGH 1151
                ||:.:.        |.:|:                   .||
Human    88 ----RRRARS--------KSAPR-------------------APP-------------------- 101

  Fly  1152 VHSWQQQEQLGKTSTLQKVTGKPPLPKMPPRSGILTHAPQETTGETVNCHRTEALPSVEREHCNQ 1216
                                |..|.|..||                       .||...||
Human   102 --------------------GLTPAPASPP-----------------------VLPRRGRE---- 119

  Fly  1217 LTGQLVAKVQAQRMRDTGLSSQIVVAEETHTVNRLAGHGDATRPTVVTAV---------PVSVAP 1272
              .|..|:.:|...|:....:...:|.|.|.:......|...|...:.|.         |...||
Human   120 --AQRAARAEASPRREPAYPALRALANELHPIKLQPQRGGPGRVAPLCAAAGRCAPPEPPAGPAP 182

  Fly  1273 VAEVDKMGLIETNLD--THETVISGKTRSLMDITCNPLSMPHKRYIVKRLNVNSVAYDVDELDAE 1335
                    .:...||  ..:.|:...||.  ..:|.|....|            .|....:....
Human   183 --------HVRCRLDIKPDDAVLQHATRG--SRSCGPTEAAH------------WARPAPQFHGL 225

  Fly  1336 VKPSPGGMASVRRPHKSMEFLLDKENQKNILPP-----ENELQKSHDHNPGALSEHQLRVQASLQ 1395
            ..|.|..||..|.|..|..:..|         |     :..|....|:               .:
Human   226 TVPGPRHMALSRTPTPSDSYCAD---------PRAFYCDGPLPGPRDY---------------AE 266

  Fly  1396 RLNIP--------DWFRHYNKGPEKAADGENACTSATGGGYRPGNFTRKRAQESGRWQGLNSKTT 1452
            |.::|        .:|  |.:.|:               |:| |:|.
Human   267 RRSLPFTTPPGPTQFF--YTEEPQ---------------GFR-GSFA------------------ 295

  Fly  1453 SLSSLGSQRSDRSPLLMSPSAHSHHGGQSSYSCGSTTIHGPAPVQIG---MGATRWSTSHLNSTQ 1514
                       .||   .|:..:::  ...|.  |..:.||:|.::|   .|..|     ....|
Human   296 -----------ASP---GPTFDAYY--PRPYP--SEELSGPSPRRMGGYYAGEVR-----TFPIQ 337

  Fly  1515 MSPGASQRGSFTR--GAPINSSFI-SVASGSGLLRNSYRQPYLGWRSTEKLSQRTPHERLA---- 1572
            ..|..|..|...|  |.|....:: .........|..|.:.:..:|..:.|::..||.|.:
Human   338 EPPSRSYYGEAPRAYGLPYGPRYVPEEPRAHSTARPFYTEDFGRYRERDVLARTYPHPRSSPAWA 402

  Fly  1573 ----NSLLTQRTAPPST--------RAGNETRTLHSVSTEIQSSIKEVTSAIVHFVNDQQQSQHP 1625
                ....|.:..|||.        ..|..|                               ..|
Human   403 DWGPRPYRTLQVVPPSDPDPLLASWHGGTGT-------------------------------SPP 436

  Fly  1626 RSRSTSPN-SRCWLESSFVGTRTLDSPQTPVIDNSPPELARKQQQLHPHQVHLDVGLSP------ 1683
            |..:.|.: ||.|......|.|..|          |....|..:.|...:|....|:||
Human   437 RLATDSRHYSRSWDNILAPGPRRED----------PLGRGRSYENLLGREVREPRGVSPEGRRPP 491

  Fly  1684 -VVSAGQLPHRMNGINRIGNGGVPTRNIAPERSLSSASLEDVLASLLGLPTTLLSGQNSNSYSSY 1747
             ||:....|.|...:                 |||..||.:...:..||        ..|.|  .
Human   492 VVVNLSTSPRRYAAL-----------------SLSETSLTEKGRAGEGL--------GRNWY--V 529

  Fly  1748 TPNAATTACAASRQQLEVQSAAELQRLRRR----SEGDAPTQEKHYSKEQSHK------------ 1796
            ||....|.......:.....|.||...|.|    :..|.||..:..|.||..:
Human   530 TPEITITDNDLRATERPSARAWELPGGRTRPPPHAAPDGPTSGRQRSLEQLDELITDLVIDSRPT 594

  Fly  1797 SNSHSVEAVDSAQPNNPK--ESRRASLGDPALAATRS---DIGSGQLQLIEG------PTTGFGS 1850
            :...|..|.|...|...:  :||.|..|.||||..||   ..||.:.....|      |......
Human   595 AGQASEPAADCLGPQLRRLLDSRPAGSGAPALAPPRSPPASAGSAEEPAAPGEAADASPEPSADE 659

  Fly  1851 GQHVRCRNTKCDQSTSPSDAKKLYKSCHNCSHLYCSRECRRAHWEKHRKACLHSRASNICRQVLA 1915
            ...:.|.|.:|.::.:..:|...:||||:|...||||.|||..|:.|:..|::.|..::||.||.
Human   660 DDLMTCSNARCRRTETMFNACLYFKSCHSCYTYYCSRLCRREDWDAHKARCVYGRVGSVCRHVLQ 724

  Fly  1916 TCKDDIDSQRHLSLLARKGSLSQGRGVVRVLFRSAEAAEGFIKNGFQ-CMGEASYVRWPDLMPAE 1979
            .|:|.....|..|.:||.|.||:||||:.:.|.|..:|:.|::.|.: .:...:|:...:|....
Human   725 FCRDSGPVHRAFSRIARVGFLSRGRGVLFLGFPSPGSADNFLRFGLEGLLLSPTYLSLRELATHA 789

  Fly  1980 MGLELYS-ELLKLSTEYKPETKMLIYVAICVVSEAPGMGQAP----------VRWERQLVSRCAK 2033
            ..|..|: ||......|:|....|:.|::.|     |.|.||          .|.....|.:.||
Human   790 APLGSYARELAAAGRLYEPAECFLLSVSVAV-----GPGTAPPGTPALPAPAPRSHGPTVRKFAK 849

  Fly  2034 LKLCKTVLAELEQHQAALLQPVSVVAVPERTEILILTFNPGQ----------HSNRELILSNILD 2088
            :.|.....|.         .|.:....|: .|.||||..||.          ...||:...:|..
Human   850 VALAAGSPAR---------PPPARSREPD-METLILTPPPGTAGLDQDGEAGRRAREVAFIHIQR 904

  Fly  2089 ILSRRGVMLSKHYPEVFERLQTYSEGQSDKFNPVTLHPRDTQTGQNFVCIIMAVHTDNELTKLPS 2153
            .|..|||.|...:|.|:|:|..:.|. :.:|.|.|::|.|.:||:.|:|:|||......|..:.|
Human   905 ELRLRGVFLRHEFPRVYEQLCEFVEA-NRRFTPTTIYPTDRRTGRPFMCMIMAASEPRALDWVAS 968

  Fly  2154 A 2154
            |
Human   969 A 969

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42748	NP_001260684.1	zf-MYND	1870..1901	CDD:280009	15/30 (50%)
AJM1	NP_001073951.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	21..49		12/38 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	61..136		28/191 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	220..242		6/21 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	264..294		8/62 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	412..443		7/61 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	539..574		8/34 (24%)
		Ribosomal_P1_P2_L12p	<611..660	CDD:304398	14/48 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	614..660		14/45 (31%)
		zf-MYND	668..710	CDD:280009	16/41 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	855..888		10/42 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_2BX6E
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004438
OrthoInspector	1	1.000	-	-		oto88588
orthoMCL	1	0.900	-	-		OOG6_110177
Panther	1	1.100	-	-	LDO	PTHR21517
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3345
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.840