DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42748 and ajm-1

DIOPT Version :9

Sequence 1:	NP_001260684.1	Gene:	CG42748 / 35442	FlyBaseID:	FBgn0261802	Length:	2190	Species:	Drosophila melanogaster
Sequence 2:	NP_001368606.1	Gene:	ajm-1 / 181148	WormBaseID:	WBGene00000100	Length:	1905	Species:	Caenorhabditis elegans

Alignment Length:	2238	Identity:	386/2238 - (17%)
Similarity:	684/2238 - (30%)	Gaps:	815/2238 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   204 SSSLVQFESLERQLT-------LQEQHQSMNSLGNSSPSLTCESGASTRARTRDSSPESR--KGS 259
            |..::.|.:..::||       :|.:..|.:|...||.:...|.|...:.:...:..|.:  :|.
Worm    39 SLRIIVFATARKRLTTTAANPDIQVEEASSSSSDTSSDTEIVEEGVFIQRQGEPTMSEKKPAQGM 103

  Fly   260 APTLSLLKRYE-SSDCSHLHQTYYELNNLNFEYKQQQELLSRSLR--EAELKSDLESSSSSSSSS 321
            ...:|||:..| .|.||....|...|..|....:....:|...|.  ..|...::.|.:.||.:|
Worm   104 PSVMSLLQTDEILSSCSDDEPTTSGLIPLPSLIQSNMSVLPNFLHTINEEESDEIRSLTGSSLAS 168

  Fly   322 DS-------SGHSLLSSCLVPGDAVATERGKQDGTNSRRIPPNSAENLSEDSGYC--EPRTLKR- 376
            ..       |..||||.  .|.:....|:.:|...||..:....:....|:....  ||||.::
Worm   169 PRTVVDRRLSNISLLSP--TPDEDFGLEQQEQQPENSEEVRGRESRTSLEEERIVVGEPRTTRQI 231

  Fly   377 EKSKSIPKNFEKLCEEEEELLLLEEGAPHSRDFKDEHDLCQTEIEQ---------TADTA---AL 429
            |.::|        ..|::.|.||:|.|...:.......:..|..|:         |:|||   .:
Worm   232 EITQS--------ASEDDRLDLLKELAKIGKSNTSTSQMSTTTPEKPEEIIDATGTSDTAEKIEV 288

  Fly   430 ACS---PSSINSSPER-------ASSESESASPLPSPTGSA----------STSSAASFTWLHNS 474
            ..|   |:...:..|.       |.||.::|..| :||.||          ..:...:....|:.
Worm   289 VISKEEPAEQKNEVEEPDYAQVPAESEDDAAQEL-APTDSAIQVVHVLEAPQKAELVTIPLAHSE 352

  Fly   475 LPDIREPRGPLSVE----INNSKPKTNGSVLATTRQNSGSTRSSS-----SADSCDGISLLGPTH 530
            ..|.:........|    .|..:.||      .|..::.|.||:|     :.|..|   ||..:.
Worm   353 AEDHKLADADRDQEEELVFNEERRKT------VTMDDNASLRSASITFDANRDEQD---LLNESF 408

  Fly   531 SLN-------------ELQVL-ERRRRPRHIRPSQRN--CHSNS--------SSEELEELDNLFV 571
            :.|             |:... ||.|.|..:.|...:  .|.::        ||.|:........
Worm   409 ASNPTDETVLMQKTKDEMDATSERPRSPLDLPPPPASVVLHPSAPPPPPPPLSSTEVVGNTTTTT 473

  Fly   572 ACHTPPRIRRSCSWNE---------------RARKVVGVASAGYLNASYQNLTLLNYTD---NWL 618
            ..|..|:     :||:               .|:.:..|.:.....:||   :..||:.   :.:
Worm   474 TTHYAPK-----TWNDPSITTAPKIPVSLLSGAQPLPSVLTQRTTTSSY---SAPNYSASSMSGV 530

  Fly   619 PAEILQKNHKRSPAEEMSKQSSNTCGNYEH----MICKG-NFLLDEISKVYDKNVSILTDKPVLD 678
            |:::..     .|...:..|||::..:|:|    .|.|. :...:::...:..:.|.:.:.||..
Worm   531 PSDVAP-----PPPLPIPNQSSSSAASYQHHHASSISKSISSSREDLLSEHATSRSTVREIPVHR 590

  Fly   679 TKLPAPVECDLNE----PIECSKVQHVQLNI---------------------------KPPPRQK 712
            ....||....:.|    |...|...||:...                           :|.....
Worm   591 APSTAPSHSSVFEYHMMPTTTSTYHHVETPSDEYYRREVMTRTIITRSTEALSQTPLGRPASPLD 655

  Fly   713 RLTQQPPAAMTFNGLVKTFDQDPTNLRTSY-----------------TQSLEQCHLDEQETAKPA 760
            |....|....|.:|..:|.::...:.:.:|                 .|..||...|.::.|:
Worm   656 RYLPYPTTTTTTSGDGRTREEKTVDYKVTYHRDIEEQERRIREDQARRQQEEQDRRDREDNAR-- 718

  Fly   761 SYPPSAISQRFLPKRRFQSQTSAAKQRSLVSSTPNLAASDDGQPESEYDIYVSSAHASMHQLPQT 825
                     |.|.:|..|......:|::|         |:....|.|        .|...:|.|.
Worm   719 ---------RILAQREHQEMERLREQQNL---------SERALAERE--------RADKERLQQE 757

  Fly   826 TTLPKPLGILLPAGSRHSFGKEVSFCPVVSKYCWQEQSSEEPTEDQFHSSEGEQGPPSDDELMDP 890
            ..|.:         .|....:|.          |....|....|::   :|..:....:.|.:|.
Worm   758 RLLRQ---------QREKKRREE----------WDRLESIRLAEEE---AELARRRALEKERIDR 800

  Fly   891 TLVHNTREN----ENIAALFEPEP-EQAHRLREPAIAQKFTGFHTNALLSASTHAEKNLSCEESA 950
            ......|:.    |...|..|.|. |:..|.:|.|..::         :.......:.:..|...
Worm   801 EKAEEERKTMERLERERARLERERLEEERRQKEKAETER---------IERERREHERIEIERIE 856

  Fly   951 NVKNKANLATPDCRDQRTEAKTTLEPEPALSSTVSLKPCAVANSSCREETPSDAINEPASATARP 1015
            .:|.:...     |::|...:...|.:..|...:.|:...      ||....:|.........|
Worm   857 RIKRERIE-----RERREREEKKAEEDRLLRERLELERIE------RERRELEARERQELELQR- 909

  Fly  1016 LSLPILSEPPTNRAHRILYSSQQLRRYEPKASPINKMPPANELSPQAAAVARTDEKHPTSRSLFS 1080
                  .|.......|:...::::||.|.:......:...:..:.:...:.:..|:....|
Worm   910 ------REAEDRERQRLEDEAREMRRREEERREAELVADVHRQAEERERLRKRQEREEAER---- 964

  Fly  1081 RFTHGLRFSLRRKKKQQQQ-EPSQVKESPKELRQSPEESQPVDFVHIPLKPPRSSQCGRLDD--- 1141
                     |.|.:.:||: :..::....:|..:..||.:..:.:....:...:....|||:
Worm   965 ---------LERIRLEQQKIDMERIDAERRERERKEEERREFELIEAARRKKEARDRDRLDEMER 1020

  Fly  1142 -------------------TIVSETSSGHVHSWQQQEQLGKTSTLQKVTG------KPPLPKMPP 1181
                               .|.:|..  .....:::|::.:.:.||:...      ...|.:...
Worm  1021 ERVREEEERREKERREQERRIAAEKE--RKRRQEEEEEIARLNELQRAAAARQAQRNAELDRQRQ 1083

  Fly  1182 RSGILTHAPQETTGETVNCHR---------TEALPSVEREHCNQL-----TGQLVAKVQAQRMRD 1232
            |..:...|.:.:..|.....|         .:....:|||..|||     ..:.|.:...:|:.|
Worm  1084 RDELDRKAQELSEREMREKERRDRERANEEAQLADLLERERHNQLIRENERREAVERANNRRLED 1148

  Fly  1233 TGLSSQI--VVAE----------------ETHTVNRLAGH---------------GDATRPTVVT 1264
            .....::  :|.|                |...:||...|               .....|.|.|
Worm  1149 RRSRDKLDHIVRERSEKEQFELEKRRLLAEKEAMNRKKNHLLSSETLAKLTQPMYYTTREPEVTT 1213

  Fly  1265 AVPVSVAPVAEVDK---------------MGLIE------------------------------- 1283
            .|...|  :..:|:               ||.::
Worm  1214 KVERQV--IERIDRNVWVEDVPYAPSQSAMGYLDNDENNRDRLYNPNDLNRNGSSRSRYQRAKNE 1276

  Fly  1284 --------TNLDTHETVISGKTRSLMDITC-------NPL------------------SMPHKRY 1315
                    ::.|:.:.|.....:|..|:|.       .||                  .:|::|.
Worm  1277 KARRDFYHSSQDSADPVTERFRKSTDDLTTRSRPEYRGPLLQKFHDSEFRTTALNETDGLPYRRM 1341

  Fly  1316 --------IVKRL--------NVNS---------------------------------VAYDVDE 1331
                    ..|.|        :.||                                 |||:.:.
Worm  1342 GPSPYEQPFAKLLEETERRYAHYNSRASNPSIYQSSRYYYPERHGQPQHTDNTRAESVVAYERES 1406

  Fly  1332 LDAEVKPSPGGMASVRRPHKSMEFLLDKENQKNILPPENELQKS----HDHNP--GALSEHQLRV 1390
            .    :.||...|.:|  .:|.::|:|:..::....|||:|||:    ||.:|  ..:||:::|.
Worm  1407 R----RESPADQAHIR--SRSADYLMDRRIREETEVPENQLQKTRVEPHDQSPRESRISEYEMRF 1465

  Fly  1391 QASLQRLNIPDWFRHYNKGPEKAADGENACTSATGGGYRPGNFTRKRAQESGRWQGLNSKTTSLS 1455
            :.|.::|.:|||:|      |....|:.|.||.    ||.||..          :.:::.||:.:
Worm  1466 RKSTEKLTVPDWYR------ENRPQGQTAQTST----YRYGNGV----------EPMSTTTTTTT 1510

  Fly  1456 SLGSQRSDRSPLLMSPSAHSHHGGQSSYSCGSTTIHGPAPV------QIGM------------GA 1502
            .:                    .|.||:.      ..|.||      .||:            ..
Worm  1511 VI--------------------NGTSSHQ------QAPPPVPPQPIGNIGLPRGMFDRYKDDIEE 1549

  Fly  1503 TRWSTSHLNSTQMSPGASQRGSFTRGAPINSSFISVASGSGLLRNSYRQPYLGWRSTEKLSQRTP 1567
            .|.|.|.|:.|.....::::|             |..|..|::...:..|  |:..:|     .|
Worm  1550 LRRSRSSLHQTGQQETSNRQG-------------STLSVGGIVDQGHALP--GYTVSE-----VP 1594

  Fly  1568 HERLANSLLTQRTAPPSTRAGNETRTLHSVSTEIQSSIKEVTSAIVHFVNDQQQSQHPRSRSTSP 1632
            :   |.:|.|.||                      |.:.||.
Worm  1595 N---AWNLHTSRT----------------------SRVVEVA----------------------- 1611

  Fly  1633 NSRCWLESSFVGTRTLDSPQTPVIDNSPPELARKQQQLHPHQVHLDVGLSPVVSAGQLPHRMNGI 1697
                   .:||||.:                         |:..                  |..
Worm  1612 -------DTFVGTSS-------------------------HEYG------------------NFT 1626

  Fly  1698 NRIGNGGVPTRNIAPERSLSSASLEDVLASLLGLPTTLLSGQNSNSYSSYT------------PN 1750
            ||.|               ...::|:||.|:....|.  :.|..|...||.            |.
Worm  1627 NRYG---------------GRVTIEEVLDSIFQKVTP--TNQRLNFDRSYPQADELFQGNVDGPG 1674

  Fly  1751 AATTACAASRQQLEVQSAAELQRLRRRSEGDAPTQEKHYSKEQSHKSNSHSVEAVDSAQPNNPKE 1815
            ..|...:..||.|:                 :|.:.:|..:.:.
Worm  1675 IYTNNYSVMRQVLK-----------------SPERAEHILQNEE--------------------- 1701

  Fly  1816 SRRASLGDPALAATRSDIGSGQLQLIEGPTTGFGSGQHVRCRNTKCDQSTSPSDAKKLYKSCHNC 1880
                                                ..|||  |:|.::...|.|:..:.||.:|
Worm  1702 ------------------------------------LFVRC--TECHRTRELSAARLFFVSCKHC 1728

  Fly  1881 SHLYCSRECRRAHWEKHRKACLHSRASNICRQVLATCKDDIDSQRHLSLLARKGSLSQGRGVVRV 1945
            ...|||||||..:|..|...|..:|.:.:|:.|:...::|..:|..:|.:||.|....|||.|.:
Worm  1729 YTYYCSRECRHNNWPNHSGRCSFARINTLCKDVIMKVREDEQAQAFMSKVARDGFSVSGRGSVNI 1793

  Fly  1946 LFRSAEAAEGFIKNGFQCMGEASYVRWPDLMPAEMGLELYS-----------ELLKLSTEYKPET 1999
            ...|.:.|:.::.||::.:  ::|       |.:..|..|:           .|:.|...|:|..
Worm  1794 RLSSPQLAQAYVSNGWRAL--SAY-------PNDQLLYYYTVKALIAERKEPSLIALCNRYEPRE 1849

  Fly  2000 KMLIYVAICVVSEAPGMGQAPVRWERQL 2027
            |.::.|:|  :::.....:.|....|:|
Worm  1850 KFILSVSI--IADIEHCPETPPPETREL 1875

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42748	NP_001260684.1	zf-MYND	1870..1901	CDD:280009	13/30 (43%)
ajm-1	NP_001368606.1	PTZ00121	<672..808	CDD:173412	28/185 (15%)
ajm-1	NP_001368606.1	zf-MYND	1706..1749	CDD:396356	17/44 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S7795
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004438
OrthoInspector	1	1.000	-	-		oto17503
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR21517
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R17000
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	6.080