DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6675 and PNLIPRP1

DIOPT Version :9

Sequence 1:	NP_610132.3	Gene:	CG6675 / 35439	FlyBaseID:	FBgn0032973	Length:	390	Species:	Drosophila melanogaster
Sequence 2:	NP_001290064.1	Gene:	PNLIPRP1 / 5407	HGNCID:	9156	Length:	467	Species:	Homo sapiens

Alignment Length:	316	Identity:	88/316 - (27%)
Similarity:	132/316 - (41%)	Gaps:	46/316 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   110 PFGSKKLRMHFYLFKREFPECGREVDFSIERKWRHCGFNASLPTRLMIHGWMSQSRGSFNRDVKN 174
            |:..:|:...|.|:..|.|...:.:..|.........|.....||.:|||::.:...|:..|:..
Human    46 PWSPEKIGTRFLLYTNENPNNFQILLLSDPSTIEASNFQMDRKTRFIIHGFIDKGDESWVTDMCK 110

  Fly   175 AYLKKGEYNVIVVDWSASSANINYFSVVKLIETFGAELAQFIRNLNRQFGADFDSMYLIGHSLGA 239
            ...:..|.|.|.|||...| ...|......:...||::||.:..|..::......::||||||||
Human   111 KLFEVEEVNCICVDWKKGS-QATYTQAANNVRVVGAQVAQMLDILLTEYSYPPSKVHLIGHSLGA 174

  Fly   240 QIAGSAGKRLKPVKVNTIFALDPAGPKFRHRGTEFRIDPSDAKYVESMHTSA-------NFGFRR 297
            .:||.||.  |...::.|..|||....|.....|.|:|||||.:|:.:||.|       .||..:
Human   175 HVAGEAGS--KTPGLSRITGLDPVEASFESTPEEVRLDPSDADFVDVIHTDAAPLIPFLGFGTNQ 237

  Fly   298 PTGSATFYPNYGAYQHSCY-------------------YLGCSHIRSYQMFAESINSPLGFWGTP 343
            ..|...|:||.|.....|.                   ::.|:|:|||:.:.|||.:|.||...|
Human   238 QMGHLDFFPNGGESMPGCKKNALSQIVDLDGIWAGTRDFVACNHLRSYKYYLESILNPDGFAAYP 302

  Fly   344 CIR-------------DNGRWQCDYSQRQSIQMAGEPSIHKEGIFYVKTSSSDPFA 386
            |..             |.|   |......:.:.||..| .::..|::.|..:..||
Human   303 CTSYKSFESDKCFPCPDQG---CPQMGHYADKFAGRTS-EEQQKFFLNTGEASNFA 354

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6675	NP_610132.3	Pancreat_lipase_like	116..381	CDD:238363	84/303 (28%)
PNLIPRP1	NP_001290064.1	Lipase	18..353	CDD:278576	86/313 (27%)
		Pancreat_lipase_like	52..349	CDD:238363	84/303 (28%)
		PLAT_PL	356..467	CDD:238857
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145294
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_28N19
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11610
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5841
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.870