DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6675 and PNLIP

DIOPT Version :9

Sequence 1:	NP_610132.3	Gene:	CG6675 / 35439	FlyBaseID:	FBgn0032973	Length:	390	Species:	Drosophila melanogaster
Sequence 2:	NP_000927.1	Gene:	PNLIP / 5406	HGNCID:	9155	Length:	465	Species:	Homo sapiens

Alignment Length:	275	Identity:	85/275 - (30%)
Similarity:	121/275 - (44%)	Gaps:	49/275 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   110 PFGSKKLRMHFYLFKREFPECGREV----------DFSIERKWRHCGFNASLPTRLMIHGWMSQS 164
            |:..|.:...|.|:..|.|...:||          :|...||           ||.:|||::.:.
Human    45 PWSPKDVNTRFLLYTNENPNNFQEVAADSSSISGSNFKTNRK-----------TRFIIHGFIDKG 98

  Fly   165 RGSFNRDVKNAYLKKGEYNVIVVDWSASSANINYFSVVKLIETFGAELAQFIRNLNRQFGADFDS 229
            ..::..:|.....|....|.|.|||...| ...|....:.|...|||:|.|:..|...||....:
Human    99 EENWLANVCKNLFKVESVNCICVDWKGGS-RTGYTQASQNIRIVGAEVAYFVEFLQSAFGYSPSN 162

  Fly   230 MYLIGHSLGAQIAGSAGKRLKPVKVNTIFALDPAGPKFRHRGTEFRIDPSDAKYVESMHT----- 289
            :::|||||||..||.||:|.... :..|..||||.|.|:......|:||||||:|:.:||
Human   163 VHVIGHSLGAHAAGEAGRRTNGT-IGRITGLDPAEPCFQGTPELVRLDPSDAKFVDVIHTDGAPI 226

  Fly   290 --SANFGFRRPTGSATFYPNYGAYQHSCY-------------------YLGCSHIRSYQMFAESI 333
              :..||..:..|...|:||.|.....|.                   :..|:|:|||:.:.:||
Human   227 VPNLGFGMSQVVGHLDFFPNGGVEMPGCKKNILSQIVDIDGIWEGTRDFAACNHLRSYKYYTDSI 291

  Fly   334 NSPLGFWGTPCIRDN 348
            .:|.||.|.||...|
Human   292 VNPDGFAGFPCASYN 306

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6675	NP_610132.3	Pancreat_lipase_like	116..381	CDD:238363	83/269 (31%)
PNLIP	NP_000927.1	Lipase	17..352	CDD:278576	85/275 (31%)
PNLIP	NP_000927.1	PLAT_PL	355..465	CDD:238857
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145324
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_28N19
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11610
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5841
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.870