DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6675 and Lpl

DIOPT Version :9

Sequence 1:	NP_610132.3	Gene:	CG6675 / 35439	FlyBaseID:	FBgn0032973	Length:	390	Species:	Drosophila melanogaster
Sequence 2:	NP_032535.2	Gene:	Lpl / 16956	MGIID:	96820	Length:	474	Species:	Mus musculus

Alignment Length:	331	Identity:	96/331 - (29%)
Similarity:	138/331 - (41%)	Gaps:	95/331 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   129 ECGREVDFS-IERKW-----------------------RHCGFNASLPTRLMIHGWMSQSRGSFN 169
            :.||  ||| ||.|:                       .:|.||.|..|.::||||  ...|.:.
Mouse    29 DAGR--DFSDIESKFALRTPEDTAEDTCHLIPGLADSVSNCHFNHSSKTFVVIHGW--TVTGMYE 89

  Fly   170 ----RDVKNAYLKKGEYNVIVVDWSASSANINYFSVVKLIETFGAELAQFIRNLNRQFGADFDSM 230
                :.|...|.::.:.||||||| ...|..:|.......:..|.::|:||..:..:|....|::
Mouse    90 SWVPKLVAALYKREPDSNVIVVDW-LYRAQQHYPVSAGYTKLVGNDVARFINWMEEEFNYPLDNV 153

  Fly   231 YLIGHSLGAQIAGSAGKRLKPVKVNTIFALDPAGPKFRHRGTEFRIDPSDAKYVESMHT------ 289
            :|:|:||||..||.||. |...|||.|..||||||.|.:.....|:.|.||.:|:.:||
Mouse   154 HLLGYSLGAHAAGVAGS-LTNKKVNRITGLDPAGPNFEYAEAPSRLSPDDADFVDVLHTFTRGSP 217

  Fly   290 SANFGFRRPTGSATFYPNYGAYQHSCYY-----------LG-------CSHIRSYQMFAESI--- 333
            ..:.|.::|.|....|||.|.:|..|..           ||       |||.||..:|.:|:
Mouse   218 GRSIGIQKPVGHVDIYPNGGTFQPGCNIGEAIRVIAERGLGDVDQLVKCSHERSIHLFIDSLLNE 282

  Fly   334 ---------NSPLGFWGTPCI--RDNGRWQCD--------YSQRQSIQMAGEPSIHKEGIFYVKT 379
                     ||...|....|:  |.|   :|:        ...::|.:|            |:||
Mouse   283 ENPSKAYRCNSKEAFEKGLCLSCRKN---RCNNLGYEINKVRAKRSSKM------------YLKT 332

  Fly   380 SSSDPF 385
            .|..|:
Mouse   333 RSQMPY 338

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6675	NP_610132.3	Pancreat_lipase_like	116..381	CDD:238363	94/325 (29%)
Lpl	NP_032535.2	Interaction with GPIHBP1. /evidence=ECO:0000250\|UniProtKB:P06858	32..53		7/22 (32%)
		lipo_lipase	33..472	CDD:132274	94/325 (29%)
		Pancreat_lipase_like	37..334	CDD:238363	89/315 (28%)
		Essential for determining substrate specificity. /evidence=ECO:0000250\|UniProtKB:P06858	243..266		3/22 (14%)
		PLAT_LPL	341..465	CDD:238856
		Important for interaction with lipoprotein particles. /evidence=ECO:0000250\|UniProtKB:P06858	417..421
		Important for heparin binding. /evidence=ECO:0000250\|UniProtKB:P06858	430..434
		Interaction with GPIHBP1. /evidence=ECO:0000250\|UniProtKB:P06858	443..467
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11610
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010