DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ttm3 and TIMM50

DIOPT Version :9

Sequence 1:	NP_610130.1	Gene:	ttm3 / 35437	FlyBaseID:	FBgn0032971	Length:	343	Species:	Drosophila melanogaster
Sequence 2:	NP_001001563.2	Gene:	TIMM50 / 92609	HGNCID:	23656	Length:	353	Species:	Homo sapiens

Alignment Length:	275	Identity:	121/275 - (44%)
Similarity:	168/275 - (61%)	Gaps:	14/275 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    71 IVMW------------AIYKLG-KPEEDHRGPIEDEFSQLPWFRQYIMRMWHTLQYYEKMMEEPQ 122
            :.:|            .:|..| .|.:::...|.|||...|...|.:.|.:...:.|.:|:.||.
Human    66 VALWLAGLLGAGGTVSVVYIFGNNPVDENGAKIPDEFDNDPILVQQLRRTYKYFKDYRQMIIEPT 130

  Fly   123 MARLLPNVVPPPYIQPPYSLVLEIKDVLVHPDWTYQTGWRFKKRPGVDYFLQQCSRNFEIVIYTS 187
            ...|||:.:..||.||||:||||:..||:||:|:..||||||||||::...||.:..:||||:||
Human   131 SPCLLPDPLQEPYYQPPYTLVLELTGVLLHPEWSLATGWRFKKRPGIETLFQQLAPLYEIVIFTS 195

  Fly   188 EQGMTAFPLLDALDPYGYIKYRLVRGATDLVEGQHTKNLDYLNRDLSRVIVVDCDPYTTPLHPDN 252
            |.|||||||:|::||:|:|.|||.|.||..::|.|.|::..||||.:||:||||......|.|.|
Human   196 ETGMTAFPLIDSVDPHGFISYRLFRDATRYMDGHHVKDISCLNRDPARVVVVDCKKEAFRLQPYN 260

  Fly   253 SLVLTKWLGNDDDVQLFDLTAFLQLIAEHQVNDVREVLRYYRQFEDPMEQFKDNQRRLQEQSQES 317
            .:.|..|.||.||..|.||:|||:.||.:.|.|||.||.:|...:||:..||..|.||:::.|:.
Human   261 GVALRPWDGNSDDRVLLDLSAFLKTIALNGVEDVRTVLEHYALEDDPLAAFKQRQSRLEQEEQQR 325

  Fly   318 IQNLPTSERQWNLTL 332
            :..|..|.:| ||.|
Human   326 LAELSKSNKQ-NLFL 339

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ttm3	NP_610130.1	CPDc	138..265	CDD:214729	69/126 (55%)
ttm3	NP_610130.1	HIP1_clath_bdg	276..332	CDD:293123	22/55 (40%)
TIMM50	NP_001001563.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	25..60
TIMM50	NP_001001563.2	HAD_FCP1-like	147..262	CDD:319823	64/114 (56%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154187
Domainoid	1	1.000	179	1.000	Domainoid score	I3536
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	265	1.000	Inparanoid score	I3057
Isobase	1	0.950	-	0.917438	Normalized mean entropy	S1903
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1142452at2759
OrthoFinder	1	1.000	-	-		FOG0003614
OrthoInspector	1	1.000	-	-		otm40883
orthoMCL	1	0.900	-	-		OOG6_102279
Panther	1	1.100	-	-	O	PTHR12210
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2489
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	12	11.850