DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ttm3 and Timm50

DIOPT Version :9

Sequence 1:	NP_610130.1	Gene:	ttm3 / 35437	FlyBaseID:	FBgn0032971	Length:	343	Species:	Drosophila melanogaster
Sequence 2:	NP_079892.1	Gene:	Timm50 / 66525	MGIID:	1913775	Length:	353	Species:	Mus musculus

Alignment Length:	263	Identity:	126/263 - (47%)
Similarity:	165/263 - (62%)	Gaps:	5/263 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    66 GSLFSIVMWAIYKLGKPEEDHRG-PIEDEFSQLPWFRQYIMRMWHTLQYYEKMMEEPQMARLLPN 129
            |...|||    |..|....|..| .|.|||...|...|.:.|.:...:.|.:|:.||....|||:
Mouse    77 GGTVSIV----YIFGNNPVDENGTKIPDEFDSDPILVQQLRRTYKYFKDYRQMIIEPTSPCLLPD 137

  Fly   130 VVPPPYIQPPYSLVLEIKDVLVHPDWTYQTGWRFKKRPGVDYFLQQCSRNFEIVIYTSEQGMTAF 194
            .:..||.||||:||||:..||:||:|:..||||||||||::...||.:..:||||:|||.|||||
Mouse   138 PLREPYYQPPYTLVLELTGVLLHPEWSLATGWRFKKRPGIETLFQQLAPLYEIVIFTSETGMTAF 202

  Fly   195 PLLDALDPYGYIKYRLVRGATDLVEGQHTKNLDYLNRDLSRVIVVDCDPYTTPLHPDNSLVLTKW 259
            ||:|::||:|:|.|||.|.||..:||.|.|::..||||.:||:||||......|.|.|.:.|..|
Mouse   203 PLIDSVDPHGFISYRLFRDATRYMEGHHVKDISCLNRDPARVVVVDCKKEAFRLQPFNGVALRPW 267

  Fly   260 LGNDDDVQLFDLTAFLQLIAEHQVNDVREVLRYYRQFEDPMEQFKDNQRRLQEQSQESIQNLPTS 324
            .||.||..|.||:|||:.||.:||.|||.||.:|...:||:|.||..|.||:::.|:.:..|..|
Mouse   268 DGNSDDRVLLDLSAFLKTIALNQVEDVRTVLEHYALEDDPLEAFKQRQSRLEQEEQQRLAELSKS 332

  Fly   325 ERQ 327
            .||
Mouse   333 NRQ 335

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ttm3	NP_610130.1	CPDc	138..265	CDD:214729	70/126 (56%)
ttm3	NP_610130.1	HIP1_clath_bdg	276..332	CDD:293123	23/52 (44%)
Timm50	NP_079892.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	23..59
Timm50	NP_079892.1	NIF	148..295	CDD:281081	81/146 (55%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167844429
Domainoid	1	1.000	178	1.000	Domainoid score	I3538
eggNOG	1	0.900	-	-		E1_COG5190
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	260	1.000	Inparanoid score	I3098
Isobase	1	0.950	-	0.917438	Normalized mean entropy	S1903
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003614
OrthoInspector	1	1.000	-	-		otm42956
orthoMCL	1	0.900	-	-		OOG6_102279
Panther	1	1.100	-	-	O	PTHR12210
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2489
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.700