DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ttm3 and timm50

DIOPT Version :9

Sequence 1:	NP_610130.1	Gene:	ttm3 / 35437	FlyBaseID:	FBgn0032971	Length:	343	Species:	Drosophila melanogaster
Sequence 2:	NP_956959.1	Gene:	timm50 / 393638	ZFINID:	ZDB-GENE-040426-1618	Length:	387	Species:	Danio rerio

Alignment Length:	275	Identity:	129/275 - (46%)
Similarity:	174/275 - (63%)	Gaps:	9/275 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 LGSLFSIVMWAIYKLGKPEEDHRG-PIEDEF-SQLPWFRQYIMRMWHTLQYYEKMMEEPQMARLL 127
            ||....||    |..|....|.:| .|.||| :.:|..:| :.|.:...:.|.:|:.||...:||
Zfish   111 LGGTVGIV----YIFGSNSVDEQGNKIPDEFDNDVPVIQQ-LRRTFKYFKDYRQMIIEPTSPKLL 170

  Fly   128 PNVVPPPYIQPPYSLVLEIKDVLVHPDWTYQTGWRFKKRPGVDYFLQQCSRNFEIVIYTSEQGMT 192
            |:.:..||.||||:||||:.|||:||:|:..||||||||||:||..||.:..:||||:|||.|||
Zfish   171 PDPLREPYYQPPYTLVLELTDVLLHPEWSLATGWRFKKRPGIDYLFQQLAPLYEIVIFTSETGMT 235

  Fly   193 AFPLLDALDPYGYIKYRLVRGATDLVEGQHTKNLDYLNRDLSRVIVVDCDPYTTPLHPDNSLVLT 257
            |:||:|::||.|::.|||.|.||..:||.|.|::..||||.|:||||||......|.|.|.|.|.
Zfish   236 AYPLIDSIDPQGFVMYRLFRDATRYMEGHHVKDVSCLNRDTSKVIVVDCKREAFGLQPFNGLALC 300

  Fly   258 KWLGNDDDVQLFDLTAFLQLIAEHQVNDVREVLRYYRQFEDPMEQFKDNQRRLQEQSQESIQNLP 322
            ||.||.:|..|:||.|||:.||...|.|||.||..|...|||:|.||..|.:|..:.::.|..:.
Zfish   301 KWDGNSEDRTLYDLAAFLKTIATSGVEDVRSVLENYAHEEDPIEAFKRRQAQLAREEEQRISEMA 365

  Fly   323 TSERQ-WNL-TLLGR 335
            ..::| ::| |:.||
Zfish   366 QQKKQGFSLGTIAGR 380

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ttm3	NP_610130.1	CPDc	138..265	CDD:214729	74/126 (59%)
ttm3	NP_610130.1	HIP1_clath_bdg	276..332	CDD:293123	20/57 (35%)
timm50	NP_956959.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	61..93
timm50	NP_956959.1	NIF	183..330	CDD:281081	83/146 (57%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170589342
Domainoid	1	1.000	183	1.000	Domainoid score	I3366
eggNOG	1	0.900	-	-		E1_COG5190
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	275	1.000	Inparanoid score	I2930
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1142452at2759
OrthoFinder	1	1.000	-	-		FOG0003614
OrthoInspector	1	1.000	-	-		otm26612
orthoMCL	1	0.900	-	-		OOG6_102279
Panther	1	1.100	-	-	O	PTHR12210
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2489
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.760