DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2528 and PREPL

DIOPT Version :9

Sequence 1:	NP_610129.3	Gene:	CG2528 / 35435	FlyBaseID:	FBgn0032969	Length:	731	Species:	Drosophila melanogaster
Sequence 2:	NP_001165074.1	Gene:	PREPL / 9581	HGNCID:	30228	Length:	727	Species:	Homo sapiens

Alignment Length:	733	Identity:	163/733 - (22%)
Similarity:	278/733 - (37%)	Gaps:	152/733 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    66 AQNNISQSF-------LERSAER---ENINS--KL-TKLWNFPK-----YGCPMRHGNYYYFFKN 112
            |:|..|:||       :::..|:   ||:::  |: |||...|:     ....::||.:.|:.:.
Human    62 ARNIPSRSFSCKDLQPVKQENEKPLPENMDAFEKVRTKLETQPQEEYEIINVEVKHGGFVYYQEG 126

  Fly   113 TGL----------QNQSVL--MQQKTLESPESIFLDTNSISSDGTTAISHIKFSEDGAFMAYGLS 165
            ..|          .|..||  :::..|:.|   |:|.             |:.:.|..::|
Human   127 CCLVRSKDEEADNDNYEVLFNLEELKLDQP---FIDC-------------IRVAPDEKYVA---- 171

  Fly   166 ESGSDWNKIRIRNTKEGI-------DLPEILEKVKFSNVS---WTKDSKGFFYGRYTDQDGIFDG 220
                  .|||..:::...       |.| ::| ..|.|||   |.||.:        |:|.:|..
Human   172 ------AKIRTEDSEASTCVIIKLSDQP-VME-ASFPNVSSFEWVKDEE--------DEDVLFYT 220

  Fly   221 SETKLAENQKLYYHLLGESPHQDILIAEFPEHPSWRFKTDISDCGKYLILSISHTVRDNMLYYAE 285
            .:..| ....:|....|::...:....|  :.||:.....::...::|.::|.:.....:.....
Human   221 FQRNL-RCHDVYRATFGDNKRNERFYTE--KDPSYFVFLYLTKDSRFLTINIMNKTTSEVWLIDG 282

  Fly   286 LGSEEKNAFQLELKPIVDKFEADFDYITNEGSNLYFHTNKDAP-NYRVIVIDVNNPAEEHWTT-- 347
            |...:....      |..:......|:.:....||..||...| .::::....:.||..:|..
Human   283 LSPWDPPVL------IQKRIHGVLYYVEHRDDELYILTNVGEPTEFKLMRTAADTPAIMNWDLFF 341

  Fly   348 PIPEHKKDV-LEWAK--CV----DGNKLVVCYNCDVKHILQARDLSTGKLIRQFGLD---IGSIN 402
            .:..:.|.: |:..|  ||    ..|.|.|       :::...|.|    :|...|.   .|.|.
Human   342 TMKRNTKVIDLDMFKDHCVLFLKHSNLLYV-------NVIGLADDS----VRSLKLPPWACGFIM 395

  Fly   403 GISGKKSNSEIFYGFSSFLSPGIIFYYDFAKPS-------EKPTVLREISLNLEGFSRDNYSVEQ 460
            ..:....|..  :...|.:.|...:.|.||:..       |.|.......|.||..|:|...|..
Human   396 DTNSDPKNCP--FQLCSPIRPPKYYTYKFAEGKLFEETGHEDPITKTSRVLRLEAKSKDGKLVPM 458

  Fly   461 VFYKSTDDTDIPMFIVQRKRDIAEPRPCLLYGYGGFNYSLMPSFGILSLMFMDTFDG-VLAFPNL 524
            ..:..||..|:            :.:|.|::.||.:...|..:|.....:.:|  || :||:.::
Human   459 TVFHKTDSEDL------------QKKPLLVHVYGAYGMDLKMNFRPERRVLVD--DGWILAYCHV 509

  Fly   525 RGGGEYGMEWHNGGRMLSKQNVFNDFQAAAEFLTKNNYTTKDRLAIQGASNGGLLVGACINQRPD 589
            |||||.|::||..||:..|.|...|.:|..:.|....::......:...|.||:|.||..|..|:
Human   510 RGGGELGLQWHADGRLTKKLNGLADLEACIKTLHGQGFSQPSLTTLTAFSAGGVLAGALCNSNPE 574

  Fly   590 LFGAAVAQVGVMDMLRFHKFT---IGHAWCSDYGNPDEKVHFANLIK-FSPLHNVHIPLNPNQEY 650
            |..|...:...:|:|.....|   :......::|||.......|.|| :.|..|:    .| |.|
Human   575 LVRAVTLEAPFLDVLNTMMDTTLPLTLEELEEWGNPSSDEKHKNYIKRYCPYQNI----KP-QHY 634

  Fly   651 PSTLILTADHDDRVSPLHSYKFVAALQEAVRY------SEYQLNPILLRVYTKAGHGAGKPTKMR 709
            ||..|...::|:||.......:...|:||:..      ..||...|:|.:.....|......|
Human   635 PSIHITAYENDERVPLKGIVSYTEKLKEAIAEHAKDTGEGYQTPNIILDIQPGGNHVIEDSHK-- 697

  Fly   710 ISEATDIITFFKKTLNVD 727
              :.|..|.|..:.|.:|
Human   698 --KITAQIKFLYEELGLD 713

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2528	NP_610129.3	Peptidase_S9_N	28..442	CDD:280970	84/435 (19%)
CG2528	NP_610129.3	Peptidase_S9	516..727	CDD:278741	62/221 (28%)
PREPL	NP_001165074.1	PtrB	113..649	CDD:224684	135/612 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158393
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840